시냅토타그민유사단백질1 은 SYTL1유전자 에 [5] [6] 단백질 이다.
모델 유기체 Sytl1 녹아웃 마우스 표현형모델 유기체는 SYTL1 기능의 연구에 사용되어 왔다.International Knockout Mouse Consortium 프로그램의 일부로서 Sytl1 이라고tm1a(KOMP)Wtsi [15] [16] 불리는 조건부 녹아웃 마우스 라인이 생성되었습니다.이것은 질병 동물 모델을 [17] [18] [19]
수컷과 암컷은 표준화된 표현형 검사를 통해 [13] [20] 호모 접합 돌연변이 생쥐에 대해 24개의 검사가 수행되었고 6개의 유의한 이상이 [13] 여성은 비정상적인 운동 조직, 미간 척추 변형, 순환 아밀라아제 수치 감소 및 평균 혈소판 부피 증가를 보였다. 양성 모두 IgG2b 수치가 감소했고 말초혈액 림프구 [13]
상호 작용 SYTL1은 RAB27A 와 [21] [22] [23] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000142765 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000028860 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Catz SD, Babior BM, Johnson JL (November 2002). "JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells" . The Biochemical Journal . 367 (Pt 3): 791–9. doi :10.1042/BJ20020345 . PMC 1222920 PMID 12137562 . ^ "Entrez Gene: SYTL1 synaptotagmin-like 1" .^ "Radiography data for Sytl1" . Wellcome Trust Sanger Institute.^ "Clinical chemistry data for Sytl1" . Wellcome Trust Sanger Institute.^ "Haematology data for Sytl1" . Wellcome Trust Sanger Institute.^ "Peripheral blood lymphocytes data for Sytl1" . 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Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biology . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 . ^ Fukuda M (April 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells" . The Journal of Biological Chemistry . 278 (17): 15390–6. doi :10.1074/jbc.M213090200 PMID 12590134 . ^ Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport" . The Journal of Biological Chemistry . 277 (28): 25423–30. doi :10.1074/jbc.M202574200 PMID 11980908 . ^ Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (March 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain" . The Journal of Biological Chemistry . 277 (11): 9212–8. doi :10.1074/jbc.M112414200 PMID 11773082 . 추가 정보 Fukuda M, Mikoshiba K (March 2001). "Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins". Biochemical and Biophysical Research Communications . 281 (5): 1226–33. doi :10.1006/bbrc.2001.4512 . PMID 11243866 . McAdara Berkowitz JK, Catz SD, Johnson JL, Ruedi JM, Thon V, Babior BM (June 2001). "JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase" . The Journal of Biological Chemistry . 276 (22): 18855–62. doi :10.1074/jbc.M011167200 PMID 11278853 . Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (March 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain" . The Journal of Biological Chemistry . 277 (11): 9212–8. doi :10.1074/jbc.M112414200 PMID 11773082 . Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport" . The Journal of Biological Chemistry . 277 (28): 25423–30. doi :10.1074/jbc.M202574200 PMID 11980908 . Fukuda M (April 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells" . The Journal of Biological Chemistry . 278 (17): 15390–6. doi :10.1074/jbc.M213090200 PMID 12590134 . Johnson JL, Ellis BA, Noack D, Seabra MC, Catz SD (November 2005). "The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase" . 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