셉틴-9 은 사람에게서 셉틴9 [5] [6] [7] 단백질 이다.
상호 작용 SEPT9은 SEPT2 [8] 및 [8] 것 으로 나타났다.
기능. ANAK , eIF4E , S100A11 과 함께 SEPT9은 의사동물 돌출, 종양세포 이동 및 침입에 [9]
임상적 의의 SEPT9 프로모터의 v2 영역은 일반 대장 [10] 대장암 조직에서 메틸화된 것으로 나타났다. 대장암 환자의 혈액에서 매우 민감한 실시간 PCR 검사를 이용하여 메틸화 SEPT9이 검출되었다. 암 샘플의 이러한 대체 메틸화 패턴은 일반 조직 [11] [12]
메틸화 SEPT9를 검출하기 위한 테스트는 대장암 [13] 변기 과이악 검사나 분변 면역 검사와 특이성과 민감성이 유사하며,[13] 의사가 적극적으로 대장내시경 검사를 권장하고 환자가 이를 거부한 경우, 이 검사는 검사가 [13]
「 」를 참조해 주세요. 레퍼런스 ^ a b c ENSG00000184640 GRCh38: 앙상블릴리즈 89: ENSG00000282302, ENSG00000184640 - Ensembl , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000059248 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Osaka M, Rowley JD, Zeleznik-Le NJ (May 1999). "MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)" . Proceedings of the National Academy of Sciences of the United States of America . 96 (11): 6428–6433. Bibcode :1999PNAS...96.6428O . doi :10.1073/pnas.96.11.6428 PMC 26898 PMID 10339604 . ^ Taki T, Ohnishi H, Shinohara K, Sako M, Bessho F, Yanagisawa M, Hayashi Y (September 1999). "AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25)". 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