로터리 호몰로그 1 은 인간에게 ROBO1 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
함수 양쪽 대칭 신경계는 두 거울 이미지 사이에 칸막이를 설정하는 특별한 중간선 구조를 가지고 있다. 어떤 액손들 은 중간선에서 나오는 장거리 화학마찰제 에 대응하여 중간선을 향해 그리고 중간선을 가로질러 투영한다. ROBO1에 의해 인코딩된 단백질은 구조적으로 드로필라 로터리유전자(면역글로불린유전자 슈퍼패밀리의 일원)에 의해 인코딩되는 드로필라 적분막단백질 과 유사하며, 액손 유도수용체 와 세포접착수용체 둘 다이며, 중추신경계 mi를 넘으려는 액손의 결정에 관여하는 것으로 알려져 있다. dline. 서로 다른 ISO 양식을 인코딩하는 두 개의 대본 변형이 ROBO1에 대해 발견되었다.[7]
임상적 유의성 ROBO1 은 심각한 난독증 을 가진 핀란드 혈통을 기반으로 한 의사소통 장애 에 연루되었다. 분석 결과, ROBO1 을 방해하는 번역이 발생했다는 것이 밝혀졌다.[8] 언어 습득 시스템 의 음운학적 기억 요소 에 대한 연구는 ROBO1 다형성들 이 이 시스템에서 기능하는 것과 관련이 있음을 시사한다.[9] 이 유전자는 양 을 나타내는 뇌의 능력과 관련이 있다고 생각되며, 한 가지 제한된 연구에서 어린 아이들의 더 나은 수학 점수와 상관관계가 있다.[10]
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