호모 사피엔스 종의 단백질 코드 유전자
A-키나아제 앵커단백질 8은 AKAP8 [5] [6] 효소 이다.
기능. A-키나아제 앵커 단백질(AKAPs)은 단백질 키나아제 A(PKA)의 조절 서브유닛에 결합하고 세포 내의 개별 위치에 결합하는 공통 기능을 가진 구조적으로 다양한 단백질의 그룹이다. 이 유전자는 AKAP 패밀리의 일원을 암호화합니다. 암호화된 단백질은 중간상 동안 핵에 위치하며 유사분열 동안 다른 위치로 재배포된다. 이 단백질은 PKA의 [6]
상호 작용 AKAP8은 다음과 상호작용하는 것 으로 입증되었습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000105127 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000024045 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skalhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Tasken K (Mar 1998). "Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95". Exp Cell Res . 238 (2): 305–16. doi :10.1006/excr.1997.3855 . PMID 9473338 . ^ a b "Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8" .^ Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I (Mar 2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95" . Biochem. J . 378 (Pt 2): 673–9. doi :10.1042/BJ20031765 . PMC 1223988 PMID 14641107 . ^ Akileswaran L, Taraska JW, Sayer JA, Gettemy JM, Coghlan VM (May 2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase" . J. Biol. Chem . 276 (20): 17448–54. doi :10.1074/jbc.M101171200 PMID 11279182 . ^ Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication" . J. Biol. Chem . 278 (29): 26750–6. doi :10.1074/jbc.M300765200 PMID 12740381 . ^ Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Dec 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex" . J. Biol. Chem . 277 (52): 50885–92. doi :10.1074/jbc.M206387200 PMID 12414807 . ^ Collas P, Le Guellec K, Taskén K (Dec 1999). 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