HLA-DQB2

HLA-DQB2
식별자
별칭	HLA-DQB2, HLA-DQB1, HLA-DXB, 주요 조직 적합성 복합체, 클래스 II, DQ 베타 2, DQB2
외부 ID	OMIM: 615161 GeneCard: HLA-DQB2
유전자 위치(인간)
쳇.	6번 염색체(인간)
끝	32,763,532 bp
RNA 표현 패턴
	표현된 상단
	피부 영역; ; 림프절; ; 폐를 끼치다; ; 흉선; ; 부신; ; 외음부; ; 식도; ; 비장의;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	MHC 등급 II 수용체 활성;
셀룰러 컴포넌트	막의 적분 성분; 내피막; 쇄석성 내피막; 내면의; 골지 기구; 전골기 망막; 소포체 망막; 막으로 막다; 골지막; 플라즈마 막; 방광막을 운반하다.; MHC급 II 단백질 복합체; 리소솜막; 소포체성 망막; ER에서 골기로 운반하는 방광막; 리소솜; 내시경적 망막의 내강측 적분 성분; 내막막;
생물학적 과정	항원 처리 및 표시; MHC 등급 II를 통한 외생 펩타이드 항원의 항원 처리 및 표시; 인터페론 매개 신호 경로; 면역 체계 과정; MHC 등급 II를 통한 펩타이드 또는 다당류 항원의 항원 처리 및 표시; 면역 반응; T세포수용체신호경로; 적응 면역 반응;
	출처:아미고 / 퀵고
직교체
	3120
	n/a
ENSG00000230675; ENSG00000196610; ENSG00000228254; ENSG00000232629; ENSG00000229493;
	ENSG00000228813; ENSG00000226165; ENSG00000224305
	n/a
	P05538
	n/a
	NM_001198858; NM_001300790; NM_182549
	n/a
	NP_001185787; NP_001287719
	n/a
	위키다타
인간 보기/편집

HLA 등급 II 조직적합성 항원, DX 베타 체인은 인간에서 HLA-DQB2 유전자에 의해 인코딩되는 단백질이다.^[3]^[4]

참조

^ ^a ^b ^c ENSG00000196610, ENSG00000228254, ENSG00000232629, ENSG00000229493, ENSG00000228813, ENSG00000226165, ENSG00000224305 GRCh38: Ensembl release 89: ENSG00000230675, ENSG00000196610, ENSG00000228254, ENSG00000232629, ENSG00000229493, ENSG00000228813, ENSG00000226165, ENSG00000224305 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Berdoz J, Tiercy JM, Rollini P, Mach B, Gorski J (May 1989). "Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC". Immunogenetics. 29 (4): 241–8. doi:10.1007/BF00717908. PMID 2564844. S2CID 8196719.
^ "Entrez Gene: HLA-DQB2 major histocompatibility complex, class II, DQ beta 2".

추가 읽기

Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. PMID 1967269.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. Bibcode:1989Natur.339..548C. doi:10.1038/339548a0. PMID 2543930. S2CID 4246781.
Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. PMID 2846691.
Jonsson AK, Hyldig-Nielsen JJ, Servenius B, et al. (1987). "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes". J. Biol. Chem. 262 (18): 8767–77. doi:10.1016/S0021-9258(18)47482-0. PMID 3036828.
Andrieu JM, Even P, Venet A (1986). "AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications". AIDS Research. 2 (3): 163–74. doi:10.1089/aid.1.1986.2.163. PMID 3489470.
Okada K, Boss JM, Prentice H, et al. (1985). "Gene organization of DC and DX subregions of the human major histocompatibility complex". Proc. Natl. Acad. Sci. U.S.A. 82 (10): 3410–4. Bibcode:1985PNAS...82.3410O. doi:10.1073/pnas.82.10.3410. PMC 397785. PMID 3858830.
Houlgatte R, Scarmato P, el Marhomy S, et al. (1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475–88. PMID 7512597.
Chirmule N, McCloskey TW, Hu R, et al. (1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. PMID 7541827.
Rowell JF, Stanhope PE, Siliciano RF (1995). "Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC". J. Immunol. 155 (1): 473–88. PMID 7602119.
Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41". Mol. Immunol. 31 (13): 977–82. doi:10.1016/0161-5890(94)90092-2. PMID 8084338.
Chirmule N, Wang XP, Hu R, et al. (1994). "Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help". Cell. Immunol. 155 (1): 169–82. doi:10.1006/cimm.1994.1110. PMID 8168144.
Callahan KM, Rowell JF, Soloski MJ, et al. (1993). "HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes". J. Immunol. 151 (6): 2928–42. PMID 8376762.
Beck S, Abdulla S, Alderton RP, et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
Ruff AL, Guarnieri FG, Staveley-O'Carroll K, et al. (1997). "The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway". J. Biol. Chem. 272 (13): 8671–8. doi:10.1074/jbc.272.13.8671. PMID 9079699.
Hsu SH, Robbins FM, Modelo RB, et al. (1998). "Identification of a new DQB1*0613 allele in a family". Tissue Antigens. 50 (6): 685–7. doi:10.1111/j.1399-0039.1997.tb02935.x. PMID 9458130.
Kanazawa S, Okamoto T, Peterlin BM (2000). "Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection". Immunity. 12 (1): 61–70. doi:10.1016/S1074-7613(00)80159-4. PMID 10661406.
Poon DT, Coren LV, Ott DE (2000). "Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging". J. Virol. 74 (8): 3918–23. doi:10.1128/JVI.74.8.3918-3923.2000. PMC 111903. PMID 10729169.

이 단백질 관련 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] ENSG00000196610, ENSG00000228254, ENSG00000232629, ENSG00000229493, ENSG00000228813, ENSG00000226165, ENSG00000224305 GRCh38: Ensembl release 89: ENSG00000230675, ENSG00000196610, ENSG00000228254, ENSG00000232629, ENSG00000229493, ENSG00000228813, ENSG00000226165, ENSG00000224305 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2564844-3] Berdoz J, Tiercy JM, Rollini P, Mach B, Gorski J (May 1989). "Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC". Immunogenetics. 29 (4): 241–8. doi:10.1007/BF00717908. PMID 2564844. S2CID 8196719.

[entrez-4] "Entrez Gene: HLA-DQB2 major histocompatibility complex, class II, DQ beta 2".

[1]

[2]

[3]

[4]

v t 주요 조직 적합성 복합 클래스
MHC 클래스 I	HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G
MHC 클래스 II	HLA-DM α β HLA-DO α β HLA-DP α1 β1 HLA-DQ α1 α2 β1 β2 β3 HLA-DR α β1 β3 β4 β5
기타	인간 백혈구 항원 소조직적합성항원 수혈 아레스틴 칼그라눌린 인간혈액군계 세포접착분자 분화 클러스터

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HLA-DQB2

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