이전 에 KIAA1199 로 알려진 세포 이동 유도 및 히알루론산 결합 단백질은 CEMIP [5] 단백질 이다.CEMIP는 CD44 [6] 히알루로니다아제 와는 독립적 으로 히알루론산 을 결합하고 그 탈중합 작용을 촉매하는 것으로 나타났다. 이러한 기능은 [7]
CEMIP는 다양한 [9] 암 뿐만 아니라 비신드롬성 [8] 난청 과 관련이 있다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000103888 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000052353 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: KIAA1199 KIAA1199" .^ Yoshida, H.; Nagaoka, A.; Kusaka-Kikushima, A.; Tobiishi, M.; Kawabata, K.; Sayo, T.; Sakai, S.; Sugiyama, Y.; Enomoto, H.; Okada, Y.; Inoue, S. (18 March 2013). "KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization" . Proceedings of the National Academy of Sciences . 110 (14): 5612–5617. doi :10.1073/pnas.1215432110 PMC 3619336 PMID 23509262 . ^ Yoshida, Hiroyuki; Nagaoka, Aya; Nakamura, Sachiko; Sugiyama, Yoshinori; Okada, Yasunori; Inoue, Shintaro (17 August 2013). "Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization" . FEBS Open Bio . 3 (1): 352–356. doi :10.1016/j.fob.2013.08.003 . PMC 3821019 PMID 24251095 . ^ Abe S, Usami S, Nakamura Y (Nov 2003). "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss" . J Hum Genet . 48 (11): 564–70. doi :10.1007/s10038-003-0079-2 PMID 14577002 . ^ Zhang, Yongsheng; Jia, Shuqin; Jiang, Wen (20 February 2014). "KIAA1199 and its biological role in human cancer and cancer cells (Review)" . Oncology Reports . 31 (4): 1503–1508. doi :10.3892/or.2014.3038 PMID 24573670 . 추가 정보 Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 6 (5): 337–45. doi :10.1093/dnares/6.5.337 PMID 10574462 . Wines ME, Lee L, Katari MS, et al. (2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics . 72 (1): 88–98. doi :10.1006/geno.2000.6466 . PMID 11247670 . Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs" . Genome Res . 12 (11): 1773–84. doi :10.1101/gr.406902 . PMC 187542 PMID 12421765 . Abe S, Katagiri T, Saito-Hisaminato A, et al. (2003). "Identification of CRYM as a Candidate Responsible for Nonsyndromic Deafness, through cDNA Microarray Analysis of Human Cochlear and Vestibular Tissues" . Am. J. Hum. Genet . 72 (1): 73–82. doi :10.1086/345398 . PMC 420014 PMID 12471561 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Guo J, Cheng H, Zhao S, Yu L (2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases" . FEBS Lett . 580 (2): 581–4. doi :10.1016/j.febslet.2005.12.076 PMID 16406369 .
