키네신 결합 단백질로도 알려진 KIF1 결합 단백질 은 KIAA1279 [5] 단백질 이다.Kif15를 스핀들 [6] Kif15와 KBP 사이의 상호작용은 중기판에서 염색체의 완벽한 정렬에 필수적이며, 그들의 상호작용의 어떤 결함도 유사분열 [7] KBP와 Kif15의 상호작용을 교란시키는 것은 유사분열 [8]
임상적 의의 결함은 Goldberg-Shprintzen 증후군(OMIM 609460)과 관련될 수 있다.
상호 작용 KIAA1279는 레티날 G 단백질 결합 [9] 디펩티드가수분해효소 [9] 1 과 상호작용하는 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000198954 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000036955 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: KIAA1279 KIAA1279" .^ Brouwers N, Mallol Martinez N, Vernos I (2017-04-26). "Role of Kif15 and its novel mitotic partner KBP in K-fiber dynamics and chromosome alignment" . PLOS ONE . 12 (4): e0174819. Bibcode :2017PLoSO..1274819B . doi :10.1371/journal.pone.0174819 PMC 5405935 PMID 28445502 . ^ Vanneste D, Takagi M, Imamoto N, Vernos I (November 2009). "The role of Hklp2 in the stabilization and maintenance of spindle bipolarity" . Current Biology . 19 (20): 1712–7. doi :10.1016/j.cub.2009.09.019 PMID 19818619 . ^ Sebastian J, Rathinasamy K (July 2019). "Benserazide Perturbs Kif15-kinesin Binding Protein Interaction with Prolonged Metaphase and Defects in Chromosomal Congression: A Study Based on in silico Modeling and Cell Culture". Molecular Informatics . 39 (3): minf.201900035. doi :10.1002/minf.201900035 . PMID 31347789 . S2CID 198911009 . ^ a b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . 추가 정보 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 . Wozniak MJ, Melzer M, Dorner C, Haring HU, Lammers R (October 2005). "The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein" . BMC Cell Biology . 6 : 35. doi :10.1186/1471-2121-6-35 . PMC 1266353 PMID 16225668 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Brooks AS, Bertoli-Avella AM, Burzynski GM, Breedveld GJ, Osinga J, Boven LG, et al. (July 2005). "Homozygous nonsense mutations in KIAA1279 are associated with malformations of the central and enteric nervous systems" . American Journal of Human Genetics . 77 (1): 120–6. doi :10.1086/431244 . PMC 1226183 PMID 15883926 . Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 6 (5): 337–45. doi :10.1093/dnares/6.5.337 PMID 10574462 .
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