BCL3

BCL3
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1K1A, 1K1B
식별자
별칭	BCL3, BCL4, D19S37, B세포 CLL/림프종 3, B세포 CLL/림프종 3, 전사 공동활성화기, BCL3 전사 공동활성화기
외부 ID	OMIM: 109560 MGI: 88140 HomoloGene: 81738 GeneCard: BCL3
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	44,760,044 bp
유전자 위치(마우스)
쳇.	7번 염색체(쥐)
끝	19,556,695 bp
RNA 표현 패턴
	표현된 상단
	간 우엽; ; 비뇨기 방광;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	DNA 결합; 단백질-매크로몰리큘 어댑터 활동; GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA 결합 전사 계수 활성; 전사 계수 바인딩; GO:0001948 단백질 결합;
셀룰러 컴포넌트	세포질; Bcl3-Bcl10 복합체; 핵종의; 세포질 과핵 지역; Bcl3/NF-kappaB2 복합체; 핵의; 시토솔; 플라즈마 막; 중체의; 세포내 막으로 둘러싸인 오르가넬; 단백질 함유 복합체;
생물학적 과정	세포독성 공정의 규제; p53 등급 중재자에 의한 DNA 손상에 대한 내인성 세포 신호 경로; DNA 결합의 규제; 전사 규정, DNA-템플링; T-헬퍼 2 세포 분화; 항균성 유머 반응; 생식선 중심 형성; 바이러스에 대한 대응; DNA 손상 반응, p53 등급 중재자에 의한 신호 전달; 세포외 매트릭스 조직; 인터페론 생산에 대한 긍정적인 규제; 세포핵 과정에 대한 부정적인 규제; 비장의 발달; 한계 영역 B 세포 분화; 번역에 대한 긍정적인 규정; 전사, DNA-템플릿; DNA 손상 자극에 대한 세포 반응; 전사의 양성적 조절, DNA-템플링; 순환 면역글로불린에 의해 매개되는 구강 면역 반응; 모낭성 수지상세포 분화; 박테리아에 대한 방어반응; T-헬퍼 1형 면역반응; 전사의 음성적 조절, DNA-템플링; I-kappaB kinase/NF-kappaB 신호; UV-C에 대한 반응; 핵 내 단백질 위치 유지; RNA 중합효소 II에 의한 전사의 양성 조절; 원생대에 대한 방위 대응; JAC-STAT를 통한 수용체 신호 경로의 음의 조절; NIK/NF-kappaB 신호 규제;
	출처:아미고 / 퀵고
직교체
	602
	12051
	ENSG00000069399
	ENSMUSG00000053175
	P20749
	Q9Z2F6
	NM_005178
	NM_033601
	NP_005169
	NP_291079
	위키다타
인간 보기/편집	마우스 보기/편집

B세포 림프종 3인코딩 단백질은 인간에게 BCL3 유전자에 의해 암호화된 단백질이다.^[5]^[6]

이 유전자는 원생종 유전자다.B세포 백혈병의 일부 사례에서 면역글로불린 알파로쿠스로의 변환으로 확인된다.이 유전자에 의해 암호화된 단백질은 7개의 앤키린 반복을 포함하고 있는데, 이는 I 카파 B 단백질에서 발견된 것과 가장 밀접한 관련이 있다.이 단백질은 NF-카파 B 호모디머와의 연관성을 통해 활성화되는 전사적 공동 활성제의 기능을 한다.이 유전자의 발현은 NF-카파 B에 의해 유도될 수 있으며, NF-카파 B는 p50 NF-카파 B의 핵거주를 제어하는 자동 관측 루프의 일부를 형성한다.^[7]

BCL2, BCL5, BCL6, BCL7A, BCL9, BCL10과 마찬가지로 림프종에서도 임상적 의의가 있다.

상호작용

BCL3는 다음과 상호작용하는 것으로 나타났다.

임상적 유의성

BCL3 유전자의 유전적 변화는 말기 알츠하이머병(LOAD)과 만성 림프구 백혈병과 연관되어 왔다.알츠하이머 환자의 뉴런에 β-아밀로이드 축적을 통해 NF-bB가 활성화되어 BCL3 발현을 유도한다.^[16]BCL3의 표현력이 증가된 것이 LOAD를 가진 환자의 뇌에서 관찰되었다.^[17]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG000069399 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000053175 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wulczyn FG, Naumann M, Scheidereit C (August 1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. 358 (6387): 597–599. Bibcode:1992Natur.358..597W. doi:10.1038/358597a0. PMID 1501714. S2CID 4363340.
^ Ohno H, Takimoto G, McKeithan TW (March 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Cell. 60 (6): 991–997. doi:10.1016/0092-8674(90)90347-H. PMID 2180580. S2CID 1919787.
^ "Entrez Gene: BCL3 B-cell CLL/lymphoma 3".
^ ^a ^b ^c ^d Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, et al. (June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–3323. doi:10.1038/sj.onc.1202717. PMID 10362352.
^ ^a ^b ^c Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". The Journal of Biological Chemistry. 274 (40): 28491–28496. doi:10.1074/jbc.274.40.28491. PMID 10497212.
^ "Molecular Interaction Database". Archived from the original on 2006-05-06. Retrieved 2012-05-08.
^ ^a ^b Thornburg NJ, Pathmanathan R, Raab-Traub N (December 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Research. 63 (23): 8293–8301. PMID 14678988.
^ Naumann M, Wulczyn FG, Scheidereit C (January 1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". The EMBO Journal. 12 (1): 213–222. doi:10.1002/j.1460-2075.1993.tb05647.x. PMC 413194. PMID 8428580.
^ Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C (September 1999). "NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes". The EMBO Journal. 18 (17): 4766–4778. doi:10.1093/emboj/18.17.4766. PMC 1171549. PMID 10469655.
^ Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (March 1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers". Cell. 72 (5): 729–739. doi:10.1016/0092-8674(93)90401-b. PMID 8453667.
^ Na SY, Choi HS, Kim JW, Na DS, Lee JW (November 1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". The Journal of Biological Chemistry. 273 (47): 30933–30938. doi:10.1074/jbc.273.47.30933. PMID 9812988.
^ Nho K, Kim S, Horgusluoglu E, Risacher SL, Shen L, Kim D, et al. (May 2017). "Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease". BMC Medical Genomics. 10 (Suppl 1): 29. doi:10.1186/s12920-017-0267-0. PMC 5461522. PMID 28589856.
^ Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. ISSN 1061-4036. PMID 34493870.

추가 읽기

Franzoso G, Bours V, Park S, Tomita-Yamaguchi M, Kelly K, Siebenlist U (September 1992). "The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition". Nature. 359 (6393): 339–342. Bibcode:1992Natur.359..339F. doi:10.1038/359339a0. PMID 1406939. S2CID 4322739.
Bhatia K, Huppi K, McKeithan T, Siwarski D, Mushinski JF, Magrath I (September 1991). "Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes". Oncogene. 6 (9): 1569–1573. PMID 1923524.
Mills FC, Brooker JS, Camerini-Otero RD (December 1990). "Sequences of human immunoglobulin switch regions: implications for recombination and transcription". Nucleic Acids Research. 18 (24): 7305–7316. doi:10.1093/nar/18.24.7305. PMC 332867. PMID 2124350.
Crossen PE, Kennedy MA, Heaton DC, Morrison MJ (September 1993). "Cloning and sequencing of a t(14;19) breakpoint that involves the C mu switch region". Genes, Chromosomes & Cancer. 8 (1): 60–62. doi:10.1002/gcc.2870080110. PMID 7691160. S2CID 85217954.
McKeithan TW, Ohno H, Dickstein J, Hume E (November 1994). "Genomic structure of the candidate proto-oncogene BCL3". Genomics. 24 (1): 120–126. doi:10.1006/geno.1994.1588. PMID 7896265.
Zhang Q, Didonato JA, Karin M, McKeithan TW (June 1994). "BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins". Molecular and Cellular Biology. 14 (6): 3915–3926. doi:10.1128/MCB.14.6.3915. PMC 358758. PMID 8196632.
Fujita T, Nolan GP, Liou HC, Scott ML, Baltimore D (July 1993). "The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers". Genes & Development. 7 (7B): 1354–1363. doi:10.1101/gad.7.7b.1354. PMID 8330739.
Naumann M, Wulczyn FG, Scheidereit C (January 1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". The EMBO Journal. 12 (1): 213–222. doi:10.1002/j.1460-2075.1993.tb05647.x. PMC 413194. PMID 8428580.
Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (March 1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers". Cell. 72 (5): 729–739. doi:10.1016/0092-8674(93)90401-B. PMID 8453667.
Nolan GP, Fujita T, Bhatia K, Huppi C, Liou HC, Scott ML, Baltimore D (June 1993). "The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner". Molecular and Cellular Biology. 13 (6): 3557–3566. doi:10.1128/MCB.13.6.3557. PMC 359825. PMID 8497270.
Watanabe N, Iwamura T, Shinoda T, Fujita T (June 1997). "Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappaB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation". The EMBO Journal. 16 (12): 3609–3620. doi:10.1093/emboj/16.12.3609. PMC 1169985. PMID 9218802.
Bundy DL, McKeithan TW (December 1997). "Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA". The Journal of Biological Chemistry. 272 (52): 33132–33139. doi:10.1074/jbc.272.52.33132. PMID 9407099.
Weyrich AS, Dixon DA, Pabla R, Elstad MR, McIntyre TM, Prescott SM, Zimmerman GA (May 1998). "Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets". Proceedings of the National Academy of Sciences of the United States of America. 95 (10): 5556–5561. Bibcode:1998PNAS...95.5556W. doi:10.1073/pnas.95.10.5556. PMC 20416. PMID 9576921.
Na SY, Choi HS, Kim JW, Na DS, Lee JW (November 1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". The Journal of Biological Chemistry. 273 (47): 30933–30938. doi:10.1074/jbc.273.47.30933. PMID 9812988.
Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, et al. (June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–3323. doi:10.1038/sj.onc.1202717. PMID 10362352.
Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". The Journal of Biological Chemistry. 274 (40): 28491–28496. doi:10.1074/jbc.274.40.28491. PMID 10497212.
Neumann M, Fries H, Scheicher C, Keikavoussi P, Kolb-Mäurer A, Bröcker E, et al. (January 2000). "Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells". Blood. 95 (1): 277–285. doi:10.1182/blood.V95.1.277. PMID 10607713.
Brasier AR, Lu M, Hai T, Lu Y, Boldogh I (August 2001). "NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence". The Journal of Biological Chemistry. 276 (34): 32080–32093. doi:10.1074/jbc.M102949200. PMID 11387332.

외부 링크

팩터북 BCL3
UCSC 게놈 브라우저의 인간 BCL3 유전체 위치 및 BCL3 유전자 세부 정보 페이지.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG000069399 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000053175 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1501714-5] Wulczyn FG, Naumann M, Scheidereit C (August 1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. 358 (6387): 597–599. Bibcode:1992Natur.358..597W. doi:10.1038/358597a0. PMID 1501714. S2CID 4363340.

[pmid2180580-6] Ohno H, Takimoto G, McKeithan TW (March 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Cell. 60 (6): 991–997. doi:10.1016/0092-8674(90)90347-H. PMID 2180580. S2CID 1919787.

[entrez-7] "Entrez Gene: BCL3 B-cell CLL/lymphoma 3".

[pmid10362352-8] Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, et al. (June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–3323. doi:10.1038/sj.onc.1202717. PMID 10362352.

[pmid10497212-9] Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". The Journal of Biological Chemistry. 274 (40): 28491–28496. doi:10.1074/jbc.274.40.28491. PMID 10497212.

[10] "Molecular Interaction Database". Archived from the original on 2006-05-06. Retrieved 2012-05-08.

[pmid14678988-11] Thornburg NJ, Pathmanathan R, Raab-Traub N (December 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Research. 63 (23): 8293–8301. PMID 14678988.

[pmid8428580-12] Naumann M, Wulczyn FG, Scheidereit C (January 1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". The EMBO Journal. 12 (1): 213–222. doi:10.1002/j.1460-2075.1993.tb05647.x. PMC 413194. PMID 8428580.

[pmid10469655-13] Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C (September 1999). "NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes". The EMBO Journal. 18 (17): 4766–4778. doi:10.1093/emboj/18.17.4766. PMC 1171549. PMID 10469655.

[pmid8453667-14] Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (March 1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers". Cell. 72 (5): 729–739. doi:10.1016/0092-8674(93)90401-b. PMID 8453667.

[pmid9812988-15] Na SY, Choi HS, Kim JW, Na DS, Lee JW (November 1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". The Journal of Biological Chemistry. 273 (47): 30933–30938. doi:10.1074/jbc.273.47.30933. PMID 9812988.

[16] Nho K, Kim S, Horgusluoglu E, Risacher SL, Shen L, Kim D, et al. (May 2017). "Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease". BMC Medical Genomics. 10 (Suppl 1): 29. doi:10.1186/s12920-017-0267-0. PMC 5461522. PMID 28589856.

[17] Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. ISSN 1061-4036. PMID 34493870.

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BCL3

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