AKAP9 식별자 에일리어스 AKAP9 외부 ID OMIM : 604001 HomoloGene : 17517 GenCard: AKAP9 맞춤법 종. 인간 마우스 엔트레즈 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 장소(UCSC) Chr 7: 91.94 ~92.11 Mb 없음 PubMed 검색[2] 없음 위키데이터
A키나아제 앵커단백질 9는 AKAP9 [3] [4] [5] 단백질 이다.AKAP9는 센트로솜 및 골지 국재 단백질 키나제 N-관련 단백질(CG-NAP) 또는 AKAP350 또는 AKAP450으로도 알려져 있다.
기능. A-키나아제 앵커 단백질(AKAPs)은 단백질 키나아제 A(PKA)의 조절 서브유닛에 결합하고 세포 내의 개별 위치에 홀로엔자임을 제한하는 공통 기능을 가진 구조적으로 다양한 단백질의 그룹이다. 이 유전자는 AKAP 패밀리의 일원을 암호화합니다. 이 유전자의 대체 스플라이싱은 중심체와 골지 기구에 국소화되고 여러 신호 전달 경로에서 수많은 신호 단백질과 상호작용하는 많은 동소 형태를 낳는다. 이러한 시그널링 단백질은 타입 II 단백질 키나제 A, 세린/트레오닌 키나제 단백질 키나제 N, 단백질 포스파타아제 1, 단백질 포스파타아제 2a , 단백질 키나제 C-엡실론 및 포스포디에스테라아제 4D3 를 [5]
모델 유기체 모델 유기체는 AKAP9 기능의 연구에 사용되어 왔다.Akap9 이라고tm1a(KOMP)Wtsi [17] [18] 불리는 조건부 녹아웃 마우스 라인이 International Knockout Mouse Consortium 프로그램의 일부로 생성되었습니다.이것은 질병 동물 모델을 생성하고 관심 있는 [19] [20] [21]
수컷과 암컷은 표준화된 표현형 검사를 통해 [16] [22] 돌연변이 생쥐에 대해 26개의 검사가 수행되었고 8개의 유의한 이상이 [16] 예상보다 적은 수의 동종 접합 돌연변이 생쥐가 젖 을 뺄 때까지 살아남았다. 나머지 테스트는 호모 접합 및 헤테로 접합 돌연변이 성인 생쥐를 대상으로 수행되었다. 성별 동물 모두 체지방과 체중 감소, 조혈 이상, 비정형 혈장 화학 패널을 보였다. 암컷 호모 접합체도 치아 형태에 이상이 나타났고 수컷은 골반 거들 뼈 [16] 이상 이 나타났다.
상호 작용 AKAP9은 다음 제품과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000127914 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, Sheng M (Apr 1998). "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1" . J Neurosci . 18 (6): 2017–27. doi :10.1523/JNEUROSCI.18-06-02017.1998 . PMC 6792910 PMID 9482789 . ^ Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD (Jul 1999). "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex". Science . 285 (5424): 93–6. doi :10.1126/science.285.5424.93 . PMID 10390370 . ^ a b "Entrez Gene: AKAP9 A kinase (PRKA) anchor protein (yotiao) 9" .^ Ong ST, Chalasani ML, Fazil MH, Prasannan P, Kizhakeyil A, Wright GD, Kelleher D, Verma NK (Mar 2018). "Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells" . Front. Immunol . 9 (397): 397. doi :10.3389/fimmu.2018.00397 PMC 5837996 PMID 29545805 . ^ "Body weight data for Akap9" . Wellcome Trust Sanger Institute.^ "Indirect calorimetry data for Akap9" . Wellcome Trust Sanger Institute.^ "Glucose tolerance test data for Akap9" . Wellcome Trust Sanger Institute.^ "DEXA data for Akap9" . Wellcome Trust Sanger Institute.^ "Radiography data for Akap9" . Wellcome Trust Sanger Institute.^ "Clinical chemistry data for Akap9" . Wellcome Trust Sanger Institute.^ "Salmonella infection data for Akap9" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Akap9" . Wellcome Trust Sanger Institute.^ Wellcome Trust Sanger Institute의 마우스 리소스 포털.^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ "International Knockout Mouse Consortium" .^ "Mouse Genome Informatics" .^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biol . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 . ^ a b Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (Sep 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex" . Mol. Biol. Cell . 13 (9): 3235–45. doi :10.1091/mbc.E02-02-0112 . PMC 124155 PMID 12221128 . ^ a b Larocca MC, Shanks RA, Tian L, Nelson DL, Stewart DM, Goldenring JR (Jun 2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus" . Mol. Biol. Cell . 15 (6): 2771–81. doi :10.1091/mbc.E03-10-0757 . PMC 420101 PMID 15047863 . ^ Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS (Jan 2002). "Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel". Science . 295 (5554): 496–9. Bibcode :2002Sci...295..496M . doi :10.1126/science.1066843 . PMID 11799244 . S2CID 6153394 . ^ a b Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y (Jun 1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus" . J. Biol. Chem . 274 (24): 17267–74. doi :10.1074/jbc.274.24.17267 PMID 10358086 . ^ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring" . Proc. Natl. Acad. Sci. U.S.A . 100 (8): 4445–50. Bibcode :2003PNAS..100.4445A . doi :10.1073/pnas.0330734100 PMC 153575 PMID 12672969 .
추가 정보 Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 5 (5): 277–86. doi :10.1093/dnares/5.5.277 PMID 9872452 . Schmidt PH, Dransfield DT, Claudio JO, Hawley RG, Trotter KW, Milgram SL, Goldenring JR (1999). "AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes" . J. Biol. Chem . 274 (5): 3055–66. doi :10.1074/jbc.274.5.3055 PMID 9915845 . Witczak O, Skålhegg BS, Keryer G, Bornens M, Taskén K, Jahnsen T, Orstavik S (1999). "Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450" . EMBO J . 18 (7): 1858–68. doi :10.1093/emboj/18.7.1858 . PMC 1171271 PMID 10202149 . Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y (1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus" . J. Biol. Chem . 274 (24): 17267–74. doi :10.1074/jbc.274.24.17267 PMID 10358086 . Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci . 3 (7): 661–9. doi :10.1038/76615 . hdl :1842/742 PMID 10862698 . S2CID 14392630 . Takahashi M, Mukai H, Oishi K, Isagawa T, Ono Y (2000). "Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP" . J. Biol. Chem . 275 (44): 34592–6. doi :10.1074/jbc.M005285200 PMID 10945988 . Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS (2002). "Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel". Science . 295 (5554): 496–9. Bibcode :2002Sci...295..496M . doi :10.1126/science.1066843 . PMID 11799244 . S2CID 6153394 . Steadman BT, Schmidt PH, Shanks RA, Lapierre LA, Goldenring JR (2002). "Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus" . J. Biol. Chem . 277 (33): 30165–76. doi :10.1074/jbc.M201914200 PMID 12015314 . Bray JD, Chennathukuzhi VM, Hecht NB (2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics . 79 (6): 799–808. doi :10.1006/geno.2002.6779 . PMID 12036294 . Shanks RA, Larocca MC, Berryman M, Edwards JC, Urushidani T, Navarre J, Goldenring JR (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member" . J. Biol. Chem . 277 (43): 40973–80. doi :10.1074/jbc.M112277200 PMID 12163479 . Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (2003). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex" . Mol. Biol. Cell . 13 (9): 3235–45. doi :10.1091/mbc.E02-02-0112 . PMC 124155 PMID 12221128 . Sillibourne JE, Milne DM, Takahashi M, Ono Y, Meek DW (2002). "Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450". J. Mol. Biol . 322 (4): 785–97. doi :10.1016/S0022-2836(02)00857-4 . PMID 12270714 . Tu H, Tang TS, Wang Z, Bezprozvanny I (2004). "Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A" . J. Biol. Chem . 279 (18): 19375–82. doi :10.1074/jbc.M313476200 PMID 14982933 . 외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
