UCHL3
UCHL3| UCHL3 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| 식별자 | |||||||||||||||||||||||||
| 에일리어스 | UCHL3, UCH-L3, 유비퀴틴C 말단 가수분해효소L3 | ||||||||||||||||||||||||
| 외부 ID | OMIM : 603090 MGI : 1355274 HomoloGene : 4377 GenCard : UCHL3 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| 맞춤법 | |||||||||||||||||||||||||
| 종. | 인간 | 마우스 | |||||||||||||||||||||||
| 엔트레즈 | |||||||||||||||||||||||||
| 앙상블 | |||||||||||||||||||||||||
| 유니프로트 | |||||||||||||||||||||||||
| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 장소(UCSC) | Chr 13: 75.55 ~75.61 Mb | Chr 14: 101.89 ~101.93 Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키데이터 | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
유비퀴틴 카르복실 말단 가수분해효소 이소자임 L3는 인체에서 UCHL3 [5][6]유전자에 의해 암호화되는 효소이다.
상호 작용
UCHL3은 NEDD8 및 타우파시 및 시뉴클레오파시 관련 돌연변이 유비퀴틴 분자 UBB+[7][8]1과 상호작용하는 것으로 나타났다.
「 」를 참조해 주세요.
- 유비퀴틴카르복시 말단 가수분해효소 L1-효소
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000118939 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022111 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science. 246 (4930): 670–3. Bibcode:1989Sci...246..670W. doi:10.1126/science.2530630. PMID 2530630.
- ^ "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)".
- ^ Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett. 585 (16): 2568–74. doi:10.1016/j.febslet.2011.06.037. PMID 21762696. S2CID 28207136.
- ^ Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID 9790970.
추가 정보
- Johnston SC, Larsen CN, Cook WJ, et al. (1997). "Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution". EMBO J. 16 (13): 3787–96. doi:10.1093/emboj/16.13.3787. PMC 1170002. PMID 9233788.
- Wilkinson KD, Laleli-Sahin E, Urbauer J, et al. (1999). "The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3". J. Mol. Biol. 291 (5): 1067–77. doi:10.1006/jmbi.1999.3038. PMID 10518943.
- Baek SH, Yoo YJ, Tanaka K, Chung CH (1999). "Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution". Biochem. Biophys. Res. Commun. 264 (1): 235–40. doi:10.1006/bbrc.1999.1492. PMID 10527871.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. 48 (5): 249–70. doi:10.1007/s10038-003-0021-7. PMID 12721789.
- Nam MJ, Madoz-Gurpide J, Wang H, et al. (2004). "Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3". Proteomics. 3 (11): 2108–15. doi:10.1002/pmic.200300594. PMID 14595809. S2CID 27511690.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Misaghi S, Galardy PJ, Meester WJ, et al. (2005). "Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate". J. Biol. Chem. 280 (2): 1512–20. doi:10.1074/jbc.M410770200. PMID 15531586.
- Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID 16402389. S2CID 6633207.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
PDB 갤러리 | |
|---|---|
|
