호모 사피엔스 종의 단백질 코드 유전자
세포질 아실 코엔자임 티오에스테르 가수분해효소는 사람 에게서 ACOT7 [5] [6] [7] [8] 효소 이다.
이 유전자는 아실 코엔자임 계열의 일원을 암호화한다. 암호화된 단백질은 팔미토일-CoA 및 기타 긴 사슬 지방산 의 CoA 티오에스테르 를 가수 분해합니다. 이 유전자의 발현 감소는 중간 측두엽 간질과 관련이 있을 수 있다. 뇌전증 다른 아세포 위치를 가진 별개 의 아이소폼을 코드하는 대체적으로 스플라이스된 전사 변형이 [8]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000097021 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000028937 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem . 126 (6): 1013–9. doi :10.1093/oxfordjournals.jbchem.a022544 . PMID 10578051 . ^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases" . J Lipid Res . 46 (9): 2029–32. doi :10.1194/jlr.E500003-JLR200 PMID 16103133 . ^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs" . FASEB J . 20 (11): 1855–64. doi :10.1096/fj.06-6042com . PMID 16940157 . S2CID 501610 . ^ a b "Entrez Gene: ACOT7 acyl-CoA thioesterase 7" . 외부 링크 추가 정보 Yamada J (2006). "Long-chain acyl-CoA hydrolase in the brain". Amino Acids . 28 (3): 273–8. doi :10.1007/s00726-005-0181-1 . PMID 15731883 . S2CID 10678899 . Yamada J, Kuramochi Y, Takagi M, et al. (2003). "Human brain acyl-CoA hydrolase isoforms encoded by a single gene". Biochem. Biophys. Res. Commun . 299 (1): 49–56. doi :10.1016/S0006-291X(02)02587-1 . PMID 12435388 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Yang JW, Czech T, Yamada J, et al. (2005). "Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy". Amino Acids . 27 (3–4): 269–75. doi :10.1007/s00726-004-0138-9 . PMID 15592755 . S2CID 2832201 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 .
