포도상구균 도메인 함유 단백질 1 은 100kDa 공동활성화제 또는 튜더 도메인 함유 단백질 11(TDRD11)로도 알려져 있으며 SND1 [5] [6] [7] [8] 단백질 이다.SND1은 RISC 복합체 의[9] [10] [11] SND1은 단백질을 함유한 튜더 도메인이며 튜더 단백질은 고도로 보존된 단백질이며 심지어 드로소필라 [12] SND1은 또한 [13]
임상적 의의 SND1은 많은[14] [15] [16] 간세포암 [10] [11] 종양 유전자로 작용한다. SND1은 NF-kappaB 및 miR-221 을 [17] [18] SND1 발현은 교종 에서 [19] Mir-184 에 의해 조절된다.
상호 작용 SND1은 [20] MYB 와 상호작용하는 것 으로 나타났습니다.
SND1은 또한 G3BP (스트레스 과립단백질)[25] [10] [11] AEG-1 과 상호작용한다.
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PDB 갤러리
2hqx : 인간 P100 튜더 도메인 보존 영역의 결정 구조
2o4x : 인간 P100 튜더 영역의 결정 구조
