복제인자 C 서브유닛 5는 RFC5 [5] [6] 단백질 이다.
기능. DNA 중합효소 델타 및 DNA 중합효소 엡실론 에 의한 프라이밍 DNA 템플릿의 연장은 세포핵항원(PCNA )과 복제인자 C(RFC)를 증식시키는 보조단백질을 필요로 한다. RFC(액티베이터 1이라고도 함)는 140, 40, 38, 37 및 36kD의 5개의 서로 다른 서브유닛으로 이루어진 단백질 복합체입니다. 이 유전자는 36kD 서브유닛을 암호화한다. 이 서브유닛은 PCNA의 C 말단 영역과 상호작용할 수 있습니다. 38kDa 및 40kDa 서브유닛과 함께 핵심 복합체를 형성한다. 코어 복합체는 체외 시스템에서 PCNA에 의해 자극되는 것으로 확인된 DNA 의존성 ATP효소 활성을 가지고 있다. 서로 다른 Isoform을 코드하는 스플라이스된 전사 변종이 [6]
상호 작용 RFC5는 다음과 상호작용하는 것 으로 나타났습니다.
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