복제인자 C 서브유닛2 는 RFC2 [5] [6] [7] 단백질 이다.
기능. DNA 중합효소 델타 및 엡실론 에 의한 프라이밍 DNA 템플릿의 연장은 보조 단백질, 증식 세포핵항원 (PCNA) 및 복제인자 C(RFC)의 작용을 필요로 한다. RFC(액티베이터 1이라고도 함)는 145, 40, 38, 37 및 36.5kD의 5개의 서로 다른 서브유닛으로 이루어진 단백질 복합체입니다. 이 유전자는 40kD 서브유닛을 암호화하며, 이 서브유닛은 ATP 결합에 관여하는 것으로 나타났다. 이 유전자의 결실은 윌리엄스 증후군과 관련이 있다 . 서로 다른 Isoforms를 코드하는 대체 스플라이스된 전사 변종이 [7]
상호 작용 RFC2는 BRD4 ,[8] CHTF18 ,[9] [10] PCNA ,[11] [12] [13] RFC4 [11] [14] [11] [14] RFC5 와 상호 작용하는 것 으로 나타났습니다.
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