호중구세포산인자4

NCF4
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1H6H, 1OEY, 1W6X, 1W70, 1Z9Q, 2DYB
식별자
에일리어스	NCF4, NCF, P40PHOX, SH3PXD4, 호중구 세포질 인자 4, CGD3
외부 ID	OMIM: 601488 MGI: 109186 HomoloGene: 525 GeneCard: NCF4
유전자 위치(인간)
크르.	22번 염색체(인간)
끝.	36,878,017 bp
유전자 위치(마우스)
크르.	15번 염색체(쥐)
끝.	78,137,780 bp
RNA발현패턴
	상단 표시 위치:
	피; ; 비장; ; 골수; ; 단구; ; 골수 세포; ; 부록; ; 림프절; ; 활막; ; 태반; ; 오른쪽 폐;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 이량화 활성; 포스파티딜이노시톨-3-인산결합; GO:0001948 단백질 결합; 포스파티딜이노시톨결합; 지질 결합; 초산화물 생성 NADPH산화효소활성화제;
셀룰러 컴포넌트	세포질; 세포; 내염색체; 막; 파골리소좀; 엔도솜막; 골기 횡단망; NADPH산화효소복합체;
생물학적 과정	혈관내피증식인자수용체신호경로; 면역 반응; GO:0048554 촉매 활성의 양성 조절; 소포체 수송; 식세포증; 호흡 버스트; 초산화물 대사 과정; 항원 처리 및 MHC 클래스 I, TAP 의존성을 통한 외인성 펩타이드 항원의 제시; 산화 스트레스에 대한 세포 반응; 세포 산화 환원 항상성;
	출처:아미고 / QuickGO
맞춤법
	4689
	17972
	ENSG00000275990; ENSG00000100365
	ENSMUSG000071715
	문제 15080
	P97369
	NM_000631; NM_013416
	NM_008677
	NP_000622; NP_038202
	NP_032703
	위키데이터
인간 보기/편집	마우스 표시/편집

호중구 세포졸인자 4는 NCF4 ^[5]^[6]유전자에 의해 인체 내에서 암호화되는 단백질이다.

기능.

이 유전자에 의해 코드된 단백질은 숙주 방어에 중요한 다성분 효소 시스템인 초산화물 생성 식세포 NADPH-옥시다아제의 세포 조절 성분이다.이 단백질은 골수 계통의 세포에서 우선적으로 발현된다.이는 주로 호중구 세포질 인자 2(NCF2/p67-phox)와 상호작용하여 호중구 세포질 인자 1(NCF1/p47-phox)과 복합체를 형성하며, 이는 작은 G 단백질 RAC1과 더욱 상호작용하여 세포 자극 시 막으로 전이된다.그런 다음 이 복합체는 효소 시스템의 막 일체형 촉매 코어인 플라보시토크롬 b를 활성화한다.이 단백질의 PX 도메인은 PI(3) 키나제의 인지질 생성물과 결합할 수 있으며, 이는 PI(3) 키나제를 매개로 한 시그널링 이벤트에서의 역할을 시사한다.이 단백질의 인산화 작용은 효소 활성을 부정적으로 조절하는 것으로 밝혀졌다.다른 방법으로 별개의 Isoform을 코드하는 스플라이스된 전사 변형이 관찰되었습니다.

임상적 의의

GWAS 연구는 NCF4에서 특정 SNP를 가진 크론병 환자가 크론병에 ^[7]걸리기 더 쉽다는 것을 보여주었다.rs4821544 변종을 가진 크론의 환자는 프로염증성 ^[8]사이토카인 GM-CSF로 자극한 후 활성산소종이 감소하였다.

상호 작용

호중구 세포질 인자 4는 Ku70,^[9] 호중구 세포질 인자^[10]^[11]^[12] 1 및 모신과 상호작용하는 것으로 나타났다.^[13]

레퍼런스

^ ^a ^b ^c ENSG00000100365 GRCh38: 앙상블릴리즈 89: ENSG00000275990, ENSG00000100365 - Ensembl, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000071715 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhan S, Vazquez N, Zhan S, Wientjes FB, Budarf ML, Schrock E, Ried T, Green ED, Chanock SJ (Nov 1996). "Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex". Blood. 88 (7): 2714–21. doi:10.1182/blood.V88.7.2714.bloodjournal8872714. PMID 8839867.
^ "Entrez Gene: NCF4 neutrophil cytosolic factor 4, 40kDa".
^ Muise AM, Xu W, Guo CH, Walters TD, Wolters VM, Fattouh R, Lam GY, Hu P, Murchie R, Sherlock M, Gana JC, Russell RK, Glogauer M, Duerr RH, Cho JH, Lees CW, Satsangi J, Wilson DC, Paterson AD, Griffiths AM, Silverberg MS, Brumell JH (2012). "NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2". Gut. 61 (7): 1028–35. doi:10.1136/gutjnl-2011-300078. PMC 3806486. PMID 21900546.
^ Somasundaram R, Deuring JJ, van der Woude CJ, Peppelenbosch MP, Fuhler GM (2012). "Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease". Gut. 61 (7): 1097, author reply 1097–8. doi:10.1136/gutjnl-2011-301344. PMID 22027479. S2CID 5315006.
^ Grandvaux N, Grizot S, Vignais PV, Dagher MC (Feb 1999). "The Ku70 autoantigen interacts with p40phox in B lymphocytes". J. Cell Sci. 112 ( Pt 4) (4): 503–13. doi:10.1242/jcs.112.4.503. PMID 9914162.
^ Lapouge K, Smith SJ, Groemping Y, Rittinger K (Mar 2002). "Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox". J. Biol. Chem. 277 (12): 10121–8. doi:10.1074/jbc.M112065200. PMID 11796733.
^ Grizot S, Grandvaux N, Fieschi F, Fauré J, Massenet C, Andrieu JP, Fuchs A, Vignais PV, Timmins PA, Dagher MC, Pebay-Peyroula E (Mar 2001). "Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox". Biochemistry. 40 (10): 3127–33. doi:10.1021/bi0028439. PMID 11258927.
^ Sathyamoorthy M, de Mendez I, Adams AG, Leto TL (Apr 1997). "p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain". J. Biol. Chem. 272 (14): 9141–6. doi:10.1074/jbc.272.14.9141. PMID 9083043.
^ Wientjes FB, Reeves EP, Soskic V, Furthmayr H, Segal AW (Nov 2001). "The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain". Biochem. Biophys. Res. Commun. 289 (2): 382–8. doi:10.1006/bbrc.2001.5982. PMID 11716484.

추가 정보

Matute JD, Arias AA, Dinauer MC, Patiño PJ (2006). "p40phox: the last NADPH oxidase subunit". Blood Cells Mol. Dis. 35 (2): 291–302. doi:10.1016/j.bcmd.2005.06.010. PMID 16102984.
Jones JH (1977). "The essence of operating room nursing. Paramedical personnel". Australas Nurses J. 7 (1): 44–5, 63–4. PMID 243433.
Leto TL, Adams AG, de Mendez I (1994). "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10650–4. Bibcode:1994PNAS...9110650L. doi:10.1073/pnas.91.22.10650. PMC 45079. PMID 7938008.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Tsunawaki S, Mizunari H, Nagata M, Tatsuzawa O, Kuratsuji T (1994). "A novel cytosolic component, p40phox, of respiratory burst oxidase associates with p67phox and is absent in patients with chronic granulomatous disease who lack p67phox". Biochem. Biophys. Res. Commun. 199 (3): 1378–87. doi:10.1006/bbrc.1994.1383. PMID 8147882.
Wientjes FB, Hsuan JJ, Totty NF, Segal AW (1993). "p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains". Biochem. J. 296 ( Pt 3) (3): 557–61. doi:10.1042/bj2960557. PMC 1137734. PMID 8280052.
Dusi S, Donini M, Rossi F (1996). "Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox". Biochem. J. 314 ( Pt 2) (2): 409–12. doi:10.1042/bj3140409. PMC 1217064. PMID 8670049.
Someya A, Nagaoka I, Nunoi H, Yamashita T (1996). "Translocation of guinea pig p40-phox during activation of NADPH oxidase". Biochim. Biophys. Acta. 1277 (3): 217–25. doi:10.1016/s0005-2728(96)00099-0. PMID 8982388.
Sathyamoorthy M, de Mendez I, Adams AG, Leto TL (1997). "p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain". J. Biol. Chem. 272 (14): 9141–6. doi:10.1074/jbc.272.14.9141. PMID 9083043.
Grogan A, Reeves E, Keep N, Wientjes F, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (1997). "Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils". J. Cell Sci. 110 ( Pt 24) (24): 3071–81. doi:10.1242/jcs.110.24.3071. PMID 9365277.
Fuchs A, Bouin AP, Rabilloud T, Vignais PV (1997). "The 40-kDa component of the phagocyte NADPH oxidase (p40phox) is phosphorylated during activation in differentiated HL60 cells". Eur. J. Biochem. 249 (2): 531–9. doi:10.1111/j.1432-1033.1997.00531.x. PMID 9370364.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bouin AP, Grandvaux N, Vignais PV, Fuchs A (1998). "p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process". J. Biol. Chem. 273 (46): 30097–103. doi:10.1074/jbc.273.46.30097. PMID 9804763.
Grandvaux N, Grizot S, Vignais PV, Dagher MC (1999). "The Ku70 autoantigen interacts with p40phox in B lymphocytes". J. Cell Sci. 112 ( Pt 4) (4): 503–13. doi:10.1242/jcs.112.4.503. PMID 9914162.
Nishiyama A, Ohno T, Iwata S, Matsui M, Hirota K, Masutani H, Nakamura H, Yodoi J (1999). "Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system". Immunol. Lett. 68 (1): 155–9. doi:10.1016/S0165-2478(99)00045-0. PMID 10397171.
Hasebe T, Someya A, Nagaoka I (1999). "Identification of a splice variant mRNA of p40phox, an NADPH oxidase component of phagocytes". FEBS Lett. 455 (3): 257–61. doi:10.1016/S0014-5793(99)00905-9. PMID 10437784. S2CID 23509959.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Vergnaud S, Paclet MH, El Benna J, Pocidalo MA, Morel F (2000). "Complementation of NADPH oxidase in p67-phox-deficient CGD patients p67-phox/p40-phox interaction". Eur. J. Biochem. 267 (4): 1059–67. doi:10.1046/j.1432-1327.2000.01097.x. PMID 10672014.
Grizot S, Grandvaux N, Fieschi F, Fauré J, Massenet C, Andrieu JP, Fuchs A, Vignais PV, Timmins PA, Dagher MC, Pebay-Peyroula E (2001). "Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox". Biochemistry. 40 (10): 3127–33. doi:10.1021/bi0028439. PMID 11258927.

[refGRCh38Ensembl-1] ENSG00000100365 GRCh38: 앙상블릴리즈 89: ENSG00000275990, ENSG00000100365 - Ensembl, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000071715 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8839867-5] Zhan S, Vazquez N, Zhan S, Wientjes FB, Budarf ML, Schrock E, Ried T, Green ED, Chanock SJ (Nov 1996). "Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex". Blood. 88 (7): 2714–21. doi:10.1182/blood.V88.7.2714.bloodjournal8872714. PMID 8839867.

[entrez-6] "Entrez Gene: NCF4 neutrophil cytosolic factor 4, 40kDa".

[pmid21900546-7] Muise AM, Xu W, Guo CH, Walters TD, Wolters VM, Fattouh R, Lam GY, Hu P, Murchie R, Sherlock M, Gana JC, Russell RK, Glogauer M, Duerr RH, Cho JH, Lees CW, Satsangi J, Wilson DC, Paterson AD, Griffiths AM, Silverberg MS, Brumell JH (2012). "NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2". Gut. 61 (7): 1028–35. doi:10.1136/gutjnl-2011-300078. PMC 3806486. PMID 21900546.

[pmid22027479-8] Somasundaram R, Deuring JJ, van der Woude CJ, Peppelenbosch MP, Fuhler GM (2012). "Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease". Gut. 61 (7): 1097, author reply 1097–8. doi:10.1136/gutjnl-2011-301344. PMID 22027479. S2CID 5315006.

[pmid9914162-9] Grandvaux N, Grizot S, Vignais PV, Dagher MC (Feb 1999). "The Ku70 autoantigen interacts with p40phox in B lymphocytes". J. Cell Sci. 112 ( Pt 4) (4): 503–13. doi:10.1242/jcs.112.4.503. PMID 9914162.

[pmid11796733-10] Lapouge K, Smith SJ, Groemping Y, Rittinger K (Mar 2002). "Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox". J. Biol. Chem. 277 (12): 10121–8. doi:10.1074/jbc.M112065200. PMID 11796733.

[pmid11258927-11] Grizot S, Grandvaux N, Fieschi F, Fauré J, Massenet C, Andrieu JP, Fuchs A, Vignais PV, Timmins PA, Dagher MC, Pebay-Peyroula E (Mar 2001). "Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox". Biochemistry. 40 (10): 3127–33. doi:10.1021/bi0028439. PMID 11258927.

[pmid9083043-12] Sathyamoorthy M, de Mendez I, Adams AG, Leto TL (Apr 1997). "p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain". J. Biol. Chem. 272 (14): 9141–6. doi:10.1074/jbc.272.14.9141. PMID 9083043.

[pmid11716484-13] Wientjes FB, Reeves EP, Soskic V, Furthmayr H, Segal AW (Nov 2001). "The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain". Biochem. Biophys. Res. Commun. 289 (2): 382–8. doi:10.1006/bbrc.2001.5982. PMID 11716484.

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[13]

v t 산화환원효소: NADH 또는 NADPH(EC 1.6)
1.6.1: NAD/NADP	NAD(P)⁺ 트랜스히드로게나아제(Si 특이적) NAD(P)⁺ 트랜스히드로게나아제(Re/Si 특이적)
1.6.2: 헴	메트헤모글로빈환원효소 NADPH-혈단백질환원효소/시토크롬P450환원효소 NADPH:시토크롬c2환원효소 레그헤모글로빈환원효소
1.6.3: 산소	NADPH산화효소 P91-PHOX 호중구세포산인자1 호중구세포산인자2 호중구세포산인자4 이중산화효소 이중산화효소 1 이중산화효소2
1.6.5: 퀴논 유사품	NADH탈수소효소
1.6.6: 질소기	트리메틸아민N-옥시드환원효소
1.6.99: 기타	NADH탈수소효소(퀴논)

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호중구세포산인자4

네임스페이스

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목차

기능.

임상적 의의

상호 작용

레퍼런스

추가 정보