호모 사피엔스 종의 단백질 코드 유전자
NACHT, LRR 및 PYD 도메인 함유 단백질 12는 인체 내 에서 NLRP12 [5] [6] [7] 단백질 이다.
NALP는 더 큰 CATERPILLER 단백질 패밀리 내에서 하위 패밀리를 형성하는 세포질 단백질입니다. NALP12와 같은 대부분의 짧은 NALP는 N-말단 피린(MEFV ; MIM 608107) 도메인(PYD)을 가지며 NACHT 도메인 , NACHT 관련 도메인(NAD) 및 C-말단 류신이 풍부한 반복 영역(LR )을 가진다. 또한 긴 NALP, NALP1(MIM 606636)은 도메인을 찾는 기능(FIIND)과 캐스파아제 모집 도메인 (CARD)을 포함하는 C 말단 확장을 가지고 있습니다.NALP는 MIM1476을 통해 프로염증성 캐스파아제 활성화에 관여합니다. [OMIM [7]
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