호모 사피엔스 종의 단백질 코드 유전자
5를 포함하는 NOD 유사 수용체 패밀리 피린 도메인 의 줄임말인 NLRP5 는 세포 내 단백질로 초기 발생에 역할 을 [5] [6] NLRP5는 NACPHT, LRR 및 PYD 도메인 포함 단백질 5(NALP5, Mater , PYPAF8 , PAN11, CLR19.8)로도 알려져 있으며, 세포질 의 NOD 수용체 패밀리에 속하는 것으로 알려진 14개의 피린 도메인 중 하나이다.
사람의 경우 NLRP5 단백질은 NLRP5 [7] [8] [9]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000171487 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000015721 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)" . Hum. Reprod . 24 (2): 415–24. doi :10.1093/humrep/den403 PMID 19054779 . ^ Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells" . J. Reprod. Dev . 56 (1): 41–8. doi :10.1262/jrd.09-098a PMID 19815987 . ^ "Entrez Gene: NLR family" .^ Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development" . Hum. Reprod . 17 (4): 903–11. doi :10.1093/humrep/17.4.903 PMID 11925379 . ^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol . 4 (2): 95–104. doi :10.1038/nrm1019 . PMID 12563287 . S2CID 31417018 . 추가 정보 Maraldi T, Riccio M, Sena P, et al. (2009). "MATER protein as substrate of PKCepsilon in human cumulus cells". Mol. Hum. Reprod . 15 (8): 499–506. doi :10.1093/molehr/gap048 . PMID 19542546 . Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia" . Cancer Res . 68 (24): 10178–86. doi :10.1158/0008-5472.CAN-08-2221 PMID 19074885 . Alimohammadi M, Björklund P, Hallgren A, et al. (2008). "Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen" . N. Engl. J. Med . 358 (10): 1018–28. doi :10.1056/NEJMoa0706487 . PMID 18322283 . S2CID 6542627 . Sena P, Riccio M, Marzona L, et al. (2009). "Human MATER localization in specific cell domains of oocytes and follicular cells" . Reprod. Biomed. Online . 18 (2): 226–34. doi :10.1016/s1472-6483(10)60260-x PMID 19192343 .
