H2AFY
H2AFY
코어 히스톤 매크로-H2A.1은 인간에서 H2AFY 유전자에 의해 암호화된 단백질이다.[5][6][7]
함수
히스톤은 진핵생물에 있는 염색체섬유의 핵 구조를 담당하는 기본적인 핵 단백질이다.뉴클레오솜은 4개의 코어 히스톤(H2A, H2B, H3 및 H4) 각각 쌍으로 구성된 히스톤 옥타머를 감싸는 약 146bp의 DNA로 구성된다.염색질 섬유는 고차 염색질 구조를 형성하기 위해 뉴클레오솜 사이의 DNA와 링커 히스톤, H1의 상호작용을 통해 더욱 압축된다.이 유전자는 히스톤 H2A 계열의 한 구성원을 암호화한 것이다.그것은 전사를 억제하고 안정적인 X 염색체 불활성화에 참여하는 뉴클레오솜의 서브셋에서 기존의 H2A 히스톤을 대체한다.대체 스플라이싱은 여러 개의 대본 변형이 서로 다른 ISO 양식을 인코딩하는 결과를 낳는다.[7]이러한 등소형질의 표현은 간세포암과 같은 여러 암과 연관되어 있다.[8]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000113648 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000015937 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
- ^ Lee Y, Hong M, Kim JW, Hong YM, Choe YK, Chang SY, Lee KS, Choe IS (Jul 1998). "Isolation of cDNA clones encoding human histone macroH2A1 subtypes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1399 (1): 73–7. doi:10.1016/s0167-4781(98)00098-0. PMID 9714746.
- ^ a b "Entrez Gene: H2AFY H2A histone family, member Y".
- ^ Rappa F, Greco A, Podrini C, Cappello F, Foti M, Bourgoin L, Peyrou M, Marino A, Scibetta N, Williams R, Mazzoccoli G, Federici M, Pazienza V, Vinciguerra M (2013). "Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma". PLOS ONE. 8 (1): e54458. Bibcode:2013PLoSO...854458R. doi:10.1371/journal.pone.0054458. PMC 3553099. PMID 23372727.
추가 읽기
- El Kharroubi A, Piras G, Zensen R, Martin MA (May 1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Molecular and Cellular Biology. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
- Costanzi C, Pehrson JR (Jun 1998). "Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals". Nature. 393 (6685): 599–601. Bibcode:1998Natur.393..599C. doi:10.1038/31275. PMID 9634239. S2CID 205001095.
- Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F (Nov 2000). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
- Chadwick BP, Willard HF (May 2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Human Molecular Genetics. 10 (10): 1101–13. doi:10.1093/hmg/10.10.1101. PMID 11331621.
- Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F (Oct 2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
- Chadwick BP, Willard HF (Jun 2002). "Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome". The Journal of Cell Biology. 157 (7): 1113–23. doi:10.1083/jcb.200112074. PMC 2173542. PMID 12082075.
- Takahashi I, Kameoka Y, Hashimoto K (Aug 2002). "MacroH2A1.2 binds the nuclear protein Spop". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1591 (1–3): 63–8. doi:10.1016/S0167-4889(02)00249-5. PMID 12183056.
- Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM (Nov 2002). "BRCA1 supports XIST RNA concentration on the inactive X chromosome". Cell. 111 (3): 393–405. doi:10.1016/S0092-8674(02)01052-8. PMID 12419249. S2CID 372211.
- Angelov D, Molla A, Perche PY, Hans F, Côté J, Khochbin S, Bouvet P, Dimitrov S (Apr 2003). "The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling". Molecular Cell. 11 (4): 1033–41. doi:10.1016/S1097-2765(03)00100-X. PMID 12718888.
- Behrends U, Schneider I, Rössler S, Frauenknecht H, Golbeck A, Lechner B, Eigenstetter G, Zobywalski C, Müller-Weihrich S, Graubner U, Schmid I, Sackerer D, Späth M, Goetz C, Prantl F, Asmuss HP, Bise K, Mautner J (Aug 2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". International Journal of Cancer. 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201. S2CID 36836051.
- Lusic M, Marcello A, Cereseto A, Giacca M (Dec 2003). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". The EMBO Journal. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
- Acín-Pérez R, Bayona-Bafaluy MP, Fernández-Silva P, Moreno-Loshuertos R, Pérez-Martos A, Bruno C, Moraes CT, Enríquez JA (Mar 2004). "Respiratory complex III is required to maintain complex I in mammalian mitochondria". Molecular Cell. 13 (6): 805–15. doi:10.1016/S1097-2765(04)00124-8. PMC 3164363. PMID 15053874.
- Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD (Jan 2005). "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA". Developmental Cell. 8 (1): 19–30. doi:10.1016/j.devcel.2004.10.019. PMID 15621527.
- Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase". Proceedings of the National Academy of Sciences of the United States of America. 102 (21): 7635–40. doi:10.1073/pnas.0408918102. PMC 1140410. PMID 15897469.
- Ioudinkova ES, Barat A, Pichugin A, Markova E, Sklyar I, Pirozhkova I, Robin C, Lipinski M, Ogryzko V, Vassetzky YS, Razin SV (2012). "Distinct distribution of ectopically expressed histone variants H2A.Bbd and MacroH2A in open and closed chromatin domains". PLOS ONE. 7 (10): e47157. Bibcode:2012PLoSO...747157I. doi:10.1371/journal.pone.0047157. PMC 3484066. PMID 23118866.
외부 링크
- PDBe-KB는 휴먼 코어 히스톤 매크로-H2A.1에 대해 PDB에서 사용할 수 있는 모든 구조 정보의 개요를 제공한다.
PDB 갤러리 | |
|---|---|
|
