호모 사피엔스 종의 단백질 코드 유전자
BCL2/아데노바이러스 E1B 19kDa 단백질 상호작용 단백질 2는 BNIP2 [5] [6] 단백질 이다.
기능. 이 유전자는 BCL2 /아데노바이러스 E1B 19kd-상호작용단백질(BNIP) 계열의 구성원이다. 구체적인 기능은 알려지지 않았지만, 바이러스 유도 세포사 보호를 담당하는 E1B 19 kDa 단백질 및 아포토시스 [6] BCL-2 의 E1B 19 kDa 유사 배열과 상호작용한다.
상호 작용 BNIP2는 다음과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000140299 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000011958 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G (November 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell . 79 (2): 341–51. doi :10.1016/0092-8674(94)90202-X . PMID 7954800 . S2CID 38609845 . ^ a b "Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2" .^ a b Low BC, Seow KT, Guy GR (December 2000). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP" . J. Biol. Chem . 275 (48): 37742–51. doi :10.1074/jbc.M004897200 PMID 10954711 . ^ a b Low BC, Lim YP, Lim J, Wong ES, Guy GR (November 1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42" . J. Biol. Chem . 274 (46): 33123–30. doi :10.1074/jbc.274.46.33123 PMID 10551883 . ^ Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (August 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochem. Biophys. Res. Commun . 308 (2): 379–85. doi :10.1016/s0006-291x(03)01387-1 . PMID 12901880 . ^ Low BC, Seow KT, Guy GR (May 2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2" . J. Biol. Chem . 275 (19): 14415–22. doi :10.1074/jbc.275.19.14415 PMID 10799524 . 외부 링크 추가 정보 Belcredito S, Vegeto E, Brusadelli A, et al. (2002). "Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2". Brain Res. Brain Res. Rev . 37 (1–3): 335–42. doi :10.1016/S0165-0173(01)00138-2 . PMID 11744098 . S2CID 22189937 . Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region" . Cell Death Differ . 6 (4): 314–25. doi :10.1038/sj.cdd.4400493 PMID 10381623 . Zhou YT, Soh UJ, Shang X, et al. (2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence" . J. Biol. Chem . 277 (9): 7483–92. doi :10.1074/jbc.M109459200 PMID 11741952 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1" . J. Biol. Chem . 278 (46): 45903–14. doi :10.1074/jbc.M304514200 PMID 12944407 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Zhou YT, Guy GR, Low BC (2005). "BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain". Exp. Cell Res . 303 (2): 263–74. doi :10.1016/j.yexcr.2004.08.044 . PMID 15652341 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
