5리폭시겐화효소산화단백질

ALOX5AP
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	2Q7R, 2Q7M
식별자
별칭	ALOX5AP, PLAP, 아라키돈산염 5-리포시겐아제 활성화 단백질
외부 ID	OMIM: 603700 MGI: 107505 HomoloGene: 1231 GeneCard: ALOX5AP
유전자 위치(인간)
쳇.	13번 염색체(인간)
끝	30,764,426 bp
유전자 위치(마우스)
쳇.	5번 염색체(쥐)
끝	149,224,963 bp
RNA 표현 패턴
	표현된 상단
	핏덩어리; ; 폐골.; ; 골수; ; 오른쪽 폐; ; 골수 세포; ; 단모세포; ; 좌측 폐 상부엽; ; 비장의; ; 폐하엽; ; 치주 섬유;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	글루타티온 전이효소 활동; 단백질 N단자 결합; 백혈구-C4 싱타아제 활동; 글루타티온 과산화효소 활동; GO:0001948 단백질 결합; 아라키돈산결합; GO:0010577 효소 활성제 활동;
셀룰러 컴포넌트	막의 적분 성분; 핵막; 소포체 망막; 막으로 막다; 핵 봉투; 소포체성 망막; 핵의;
생물학적 과정	칼슘 이온에 대한 세포 반응; 백혈구 대사 과정; GO:0048554 촉매 활성 양성 조절; 단백질 균질화; Lipoxygenase 경로; 백혈병 생합성 과정; 리우신 대사 과정; 세포 산화제 해독; 리우산신 생합성 과정;
	출처:아미고 / 퀵고
직교체
	241
	11690
	ENSG00000132965
	ENSMUSG00000060063
	P20292
	P30355
	NM_001204406; NM_001629
	NM_009663; NM_001308462
	NP_001191335; NP_001620
	NP_001295391; NP_033793
	위키다타
인간 보기/편집	마우스 보기/편집

아라키돈산염 5-리포시겐화효소 활성 단백질, 즉 플랩으로도 알려진 아라크돈산염은 인간에서 ALOX5AP 유전자에 의해 인코딩되는 단백질이다.^[5]^[6]

함수

플랩은 5리포크시제네제의 활성화와 따라서 백혈구제네, 5리드로크시오사테트라에노산, 5-옥소-eicosatetraeno산, 리판신과 레졸바 등급의 프로-리졸브 매개체의 생산을 위해 필요하다.^[7]^[8]그것은 핵막 안에 들어 있는 일체형 단백질이다.PLAP는 호흡기 질환과 심혈관 질환에 관여하는 염증의 지질 매개체인 백혈구 합성에 필요하다.FLAP는 5립옥시제나 아민산-빈드 단백질에 대한 멤브레인 앵커의 기능을 한다.어떻게 FLAP가 5-lipoxygenase를 활성화시키는지 완전히 이해되지는 않지만, 둘 사이에는 물리적 상호작용이 있다.PLAP 구조는 4개의 투과성 알파 나선형으로 구성되지만, 통을 형성하는 3's(트리머)에서 발견된다.통의 높이는 약 60A이고 폭은 36A이다.^[9]

임상적 유의성

PLAP 단백질을 만들어야 하는 로이코트리엔은 알레르기 및 호흡기 질환에서 병리학적 역할이 확립되어 있다.동물과 인간의 유전적 증거는 그들이 또한 아테롬성 동맥경화증, 심근경색, 뇌졸중에도 중요한 역할을 할 수 있다는 것을 암시한다.FLAP의 구조는 호흡기 및 심혈관 질환에 대한 새로운 치료법의 개발과, FLAP의 세포 생물학 및 백혈구 생합성에서의 그것의 역할을 조사하는 집중 실험의 설계에 대한 도구를 제공한다.^[9]

억제제

AM-679^[10]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000132965 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000060063 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kennedy BP, Diehl RE, Boie Y, Adam M, Dixon RA (May 1991). "Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP)". The Journal of Biological Chemistry. 266 (13): 8511–6. PMID 1673682.
^ Yandava CN, Kennedy BP, Pillari A, Duncan AM, Drazen JM (February 1999). "Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12". Genomics. 56 (1): 131–3. doi:10.1006/geno.1998.5651. PMID 10036194.
^ Peters-Golden M, Brock TG (2003). "5-lipoxygenase and FLAP". Prostaglandins, Leukotrienes, and Essential Fatty Acids. 69 (2–3): 99–109. doi:10.1016/S0952-3278(03)00070-X. PMID 12895592.
^ Serhan CN, Chiang N, Dalli J, Levy BD (2015). "Lipid mediators in the resolution of inflammation". Cold Spring Harbor Perspectives in Biology. 7 (2): a016311. doi:10.1101/cshperspect.a016311. PMC 4315926. PMID 25359497.
^ ^a ^b PDB: 2Q7r;Ferguson AD, McKeever BM, Xu S, Wisniewski D, Miller DK, Yamin TT, Spencer RH, Chu L, Ujjainwalla F, Cunningham BR, Evans JF, Becker JW (July 2007). "Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein". Science. 317 (5837): 510–2. Bibcode:2007Sci...317..510F. doi:10.1126/science.1144346. PMID 17600184.
^ Musiyenko A, Correa L, Stock N, Hutchinson JH, Lorrain DS, Bain G, Evans JF, Barik S (November 2009). "A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye". Clinical and Vaccine Immunology. 16 (11): 1654–9. doi:10.1128/CVI.00220-09. PMC 2772391. PMID 19759251.

추가 읽기

Bevan S, Lorenz MW, Sitzer M, Markus HS (March 2009). "Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study". Stroke. 40 (3): 696–701. doi:10.1161/STROKEAHA.108.525733. PMID 19131661.
Yoshida T, Kato K, Yokoi K, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Suzuki T, Nozawa Y, Yamada Y (April 2009). "Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus". International Journal of Molecular Medicine. 23 (4): 529–37. doi:10.3892/ijmm_00000161. PMID 19288030.
He YL, Zhu M, Jin XP, Zhou YL (November 2009). "[Relationship of polymorphism of SG13S114A/T in ALOX5AP gene with atherosclerotic cerebral infarction]". Zhejiang da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 38 (6): 630–3. PMID 20014490.
Quarta G, Stanzione R, Evangelista A, Zanda B, Di Angelantonio E, Marchitti S, Di Castro S, Di Vavo M, Volpe M, Rubattu S (November 2009). "Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians". European Journal of Human Genetics. 17 (11): 1448–53. doi:10.1038/ejhg.2009.71. PMC 2986684. PMID 19417766.
Wang Q (May 2005). "Molecular genetics of coronary artery disease". Current Opinion in Cardiology. 20 (3): 182–8. doi:10.1097/01.hco.0000160373.77190.f1. PMC 1579824. PMID 15861005.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (December 2009). "Integrative predictive model of coronary artery calcification in atherosclerosis". Circulation. 120 (24): 2448–54. doi:10.1161/CIRCULATIONAHA.109.865501. PMC 2810344. PMID 19948975.
York TP, Vargas-Irwin C, Anderson WH, van den Oord EJ (May 2009). "Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity". Pharmacogenomics. 10 (5): 753–67. doi:10.2217/pgs.09.19. PMID 19450127.
Bizzintino JA, Khoo SK, Zhang G, Martin AC, Rueter K, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN, Hayden CM (July 2009). "Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma". Prostaglandins, Leukotrienes, and Essential Fatty Acids. 81 (1): 9–15. doi:10.1016/j.plefa.2009.05.022. PMID 19524426.
Zintzaras E, Rodopoulou P, Sakellaridis N (March 2009). "Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis". American Journal of Epidemiology. 169 (5): 523–32. doi:10.1093/aje/kwn368. PMID 19126581.
van der Net JB, Janssens AC, Defesche JC, Kastelein JJ, Sijbrands EJ, Steyerberg EW (February 2009). "Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia". The American Journal of Cardiology. 103 (3): 375–80. doi:10.1016/j.amjcard.2008.09.093. PMID 19166692.
Liu J, Sun K, Bai Y, Zhang W, Wang X, Wang Y, Wang H, Chen J, Song X, Xin Y, Liu Z, Hui R (June 2009). "Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study". Human Genetics. 125 (5–6): 649–56. doi:10.1007/s00439-009-0659-0. PMID 19373490.
Zhao J, Quyyumi AA, Patel R, Zafari AM, Veledar E, Onufrak S, Shallenberger LH, Jones L, Vaccarino V (September 2009). "Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene". Psychosomatic Medicine. 71 (7): 691–6. doi:10.1097/PSY.0b013e3181b05c57. PMC 3113512. PMID 19622707.
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Vickers PJ (October 1995). "5-Lipoxygenase-activating protein (FLAP)". Journal of Lipid Mediators and Cell Signalling. 12 (2–3): 185–94. doi:10.1016/0929-7855(95)00018-L. PMID 8777565.
Via M, De Giacomo A, Corvol H, Eng C, Seibold MA, Gillett C, Galanter J, Sen S, Tcheurekdjian H, Chapela R, Rodríguez-Santana JR, Rodríguez-Cintrón W, Thyne S, Avila PC, Choudhry S, González Burchard E (April 2010). "The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos". Clinical and Experimental Allergy. 40 (4): 582–9. doi:10.1111/j.1365-2222.2009.03438.x. PMC 2866051. PMID 20067482.
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Oosterveer DM, Versmissen J, Yazdanpanah M, van der Net JB, Defesche JC, Kastelein JJ, Sijbrands EJ (September 2009). "5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia". Atherosclerosis. 206 (1): 223–7. doi:10.1016/j.atherosclerosis.2009.02.019. PMID 19361804.

외부 링크

미국 국립 의학 도서관의 5-lipxygenase-activation+단백질(MesH)
UCSC 게놈 브라우저의 인간 ALOX5AP 게놈 위치 및 ALOX5AP 유전자 세부 정보 페이지.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000132965 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000060063 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1673682-5] Kennedy BP, Diehl RE, Boie Y, Adam M, Dixon RA (May 1991). "Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP)". The Journal of Biological Chemistry. 266 (13): 8511–6. PMID 1673682.

[pmid10036194-6] Yandava CN, Kennedy BP, Pillari A, Duncan AM, Drazen JM (February 1999). "Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12". Genomics. 56 (1): 131–3. doi:10.1006/geno.1998.5651. PMID 10036194.

[Peters-Golden-7] Peters-Golden M, Brock TG (2003). "5-lipoxygenase and FLAP". Prostaglandins, Leukotrienes, and Essential Fatty Acids. 69 (2–3): 99–109. doi:10.1016/S0952-3278(03)00070-X. PMID 12895592.

[pmid25359497-8] Serhan CN, Chiang N, Dalli J, Levy BD (2015). "Lipid mediators in the resolution of inflammation". Cold Spring Harbor Perspectives in Biology. 7 (2): a016311. doi:10.1101/cshperspect.a016311. PMC 4315926. PMID 25359497.

[FergusonMcKeever2007-9] PDB: 2Q7r;Ferguson AD, McKeever BM, Xu S, Wisniewski D, Miller DK, Yamin TT, Spencer RH, Chu L, Ujjainwalla F, Cunningham BR, Evans JF, Becker JW (July 2007). "Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein". Science. 317 (5837): 510–2. Bibcode:2007Sci...317..510F. doi:10.1126/science.1144346. PMID 17600184.

[10] Musiyenko A, Correa L, Stock N, Hutchinson JH, Lorrain DS, Bain G, Evans JF, Barik S (November 2009). "A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye". Clinical and Vaccine Immunology. 16 (11): 1654–9. doi:10.1128/CVI.00220-09. PMC 2772391. PMID 19759251.

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v t 대사: 지질대사 – 아이코사노이드 대사효소
전구체	인지질 A2 인지질 C 디아실글리세롤리파아제
프로스타노이드	사이클록시제나아제 PTGS1 PTGS2 PGD2 싱타아제 PGE 싱타아제 프로스타글란딘-E2 9-감소효소 PGI2 싱타아제 TXA 싱타아제
로이코트리아인	5-리폭시겐화효소 활성 단백질/아라키돈산염 5리폭시겐화효소 LTA4 하이드롤라아제(B4 합성) LTC4 싱타아제 감마-글루타밀 트랜스펩티다아제 LT4 하이드롤라제
그룹화되지 않음	HPGD

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5리폭시겐화효소산화단백질

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