TCF7L1로도 알려진 전사인자 7-like 1은 인간 의 [5]
이 유전자는 T세포인자/림포이드증강인자 계열의 전사인자를 코드한다. 이러한 전사 인자는 베타 카테닌에 의해 활성화되고, Wnt 신호 경로를 매개하며, 변환 성장인자 베타 신호 경로에 의해 길항된다. 암호화된 단백질은 높은 이동성 그룹 박스 DNA 결합 도메인을 포함하고 세포 주기 유전자 및 세포 [5] 노화 조절에 참여합니다.
모델 유기체 모델 유기체는 TCF7L1 기능의 연구에 사용되어 왔다.Tcf7l1 이라고tm1a(EUCOMM)Wtsi [10] [11] 불리는 조건부 녹아웃 마우스 라인은 International Knockout Mouse Consortium 프로그램의 일부로 생성되었습니다.이것은 질병 동물 모델을 생성하고 관심 있는 [12] [13] [14]
수컷과 암컷은 표준화된 표현형 검사를 통해 [8] [15] 돌연변이 생쥐에 대해 24개의 검사가 수행되었고 2개의 유의한 이상이 [8] 임신 기간 동안 동종 돌연변이 배아는 거의 확인되지 않았고, 살아남은 배아는 심각한 두개골 안면 결함을 가지고 있었다. 젖 을 뗄 때까지 살아남은 사람은 없었다.나머지 테스트는 헤테로 접합 돌연변이 성체 생쥐를 대상으로 수행되었으며, 이러한 [8]
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