텔레포니 바이너리 부호화 디지털 부호화 방법에 대해서는, 바이너리 부호화 10 진수를 참조 해 주세요. Tubulin 특이적 샤페론 D는 TBCD 유전자에 [5] 의해 인간에서 암호화되는 단백질 이다.
기능. 보조인자 D는 접이식 중간체로부터 올바르게 접힌 베타-튜브린으로 이어지는 경로에 관여하는 4가지 단백질(A, D, D, E, C) 중 하나이다. 보조인자 A 및 D는 준원어민 확인에서 베타튜브린 중간체를 포착하고 안정화시키는 역할을 하는 것으로 생각된다. 보조인자 E는 보조인자 D/베타-튜브린 복합체에 결합하고, 보조인자 C와의 상호작용은 자연 상태로 [5] 커밋된 베타-튜브린 폴리펩타이드의 방출을 일으킨다.
상호 작용 TBCD는 ARL2 와 [6] [7] 대화하는 것 으로 나타났습니다.
레퍼런스 ^ a b c ENSG00000141556 GRCh38: 앙상블 릴리즈 89: ENSG00000278759, ENSG00000141556 : Ensembl , 2017년 5월 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000039230 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ a b "Entrez Gene: TBCD tubulin folding cofactor D" . ^ Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A" . J. Biol. Chem . 278 (42): 40829–36. doi :10.1074/jbc.M308678200 . PMID 12912990 . ^ Bhamidipati A, Lewis SA, Cowan NJ (May 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin" . J. Cell Biol . 149 (5): 1087–96. doi :10.1083/jcb.149.5.1087 . PMC 2174823 . PMID 10831612 . 추가 정보 Lewis SA, Tian G, Vainberg IE, Cowan NJ (1996). "Chaperonin-mediated folding of actin and tubulin" . J. Cell Biol . 132 (1–2): 1–4. doi :10.1083/jcb.132.1.1 . PMC 2120700 . PMID 8567715 . Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ (1996). "Pathway leading to correctly folded beta-tubulin" . Cell . 86 (2): 287–96. doi :10.1016/S0092-8674(00)80100-2 . PMID 8706133 . S2CID 18359371 . Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 . PMID 9110174 . Tian G, Lewis SA, Feierbach B, Stearns T, Rommelaere H, Ampe C, Cowan NJ (1997). "Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors" . J. Cell Biol . 138 (4): 821–32. doi :10.1083/jcb.138.4.821 . PMC 2138046 . PMID 9265649 . Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 6 (1): 63–70. doi :10.1093/dnares/6.1.63 . PMID 10231032 . Martín L, Fanarraga ML, Aloria K, Zabala JC (2000). "Tubulin folding cofactor D is a microtubule destabilizing protein" . FEBS Lett . 470 (1): 93–5. doi :10.1016/S0014-5793(00)01293-X . PMID 10722852 . S2CID 35012741 . Bhamidipati A, Lewis SA, Cowan NJ (2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin" . J. Cell Biol . 149 (5): 1087–96. doi :10.1083/jcb.149.5.1087 . PMC 2174823 . PMID 10831612 . Schubert A, Cattaruzza M, Hecker M, Darmer D, Holtz J, Morawietz H (2001). "Shear stress-dependent regulation of the human beta-tubulin folding cofactor D gene" . Circ. Res . 87 (12): 1188–94. doi :10.1161/01.res.87.12.1188 . PMID 11110777 . Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis . 8 : 205–20. PMID 12107410 . Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A" . J. Biol. Chem . 278 (42): 40829–36. doi :10.1074/jbc.M308678200 . PMID 12912990 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 . PMID 15231748 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .