ARL2

ARL2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	3DOE, 3DOF
식별자
에일리어스	ARL2, ARFL2, GTPase2, MRCS1과 같은 ADP 리보실화인자
외부 ID	OMIM: 601175 MGI: 1928393 HomoloGene: 1260 GeneCard: ARL2
유전자 위치(인간)
크르.	11번 염색체(인간)
끝.	65,022,184 bp
유전자 위치(마우스)
크르.	19번 염색체(쥐)
끝.	6,191,578 bp
RNA발현패턴
	상단 표시 위치:
	핵액컴벤스; ; 미산핵; ; 창호; ; 경골 신경; ; 좌관상동맥; ; 상행 대동맥; ; 슬와 동맥; ; 위점막; ; 위근; ; 우관상 동맥;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	뉴클레오티드 결합; GTP 바인딩; GTPase억제제활성; GO:0001948 단백질 결합; GO:0006184 GTPase 액티비티; GDP 바인딩;
셀룰러 컴포넌트	세포질; 중심체; 외측 혈장막; 미토콘드리아 막간 공간; 세포내 해부학적 구조; 미소관 조직 센터; 미토콘드리아 매트릭스; 미토콘드리아; 세포골격; 핵; 핵소체; 골지 장치; 세포; 국소 접착; 섬모; 미소관 세포골격;
생물학적 과정	튜브린 착화체 조립체; 인슐린 분비 조절; GO:0034259 GTPase 활성 음성 조절; 미소관 중합 조절; 이세포밀접합체; 미소관 중합 양성 조절; 세포 주기; 핵내 단백질 위치 유지; 세포-세포 접착의 양성 조절; 중심체 사이클;
	출처:아미고 / QuickGO
맞춤법
	402
	56327
	ENSG00000213465
	ENSMUSG000024944
	P36404
	Q9D0J4
	NM_001667; NM_001199745
	NM_019722
	NP_001186674; NP_001658
	NP_062696
	위키데이터
인간 보기/편집	마우스 표시/편집

ADP-리보실화인자 유사단백질 2는 ARL2 ^[5]^[6]^[7]유전자에 의해 인체 내에서 부호화되는 단백질이다.

기능.

ADP-리보실화인자(ARF) 유전자는 RAS 슈퍼패밀리의 작은 GTP 결합 단백질이다.ARL2는 기능적으로 별개의 ARL 유사 ^[7]유전자 그룹의 구성원이다.
광수용체에서 ARL2는 지방막 관련 단백질의 ^[8]운송에 관여한다.
ARL2 단백질의 활성 증가는 미토콘드리아 융합 증가와 강한 상관관계가 있는 반면, ARL2 활성의 손실은 융합 속도를 ^[9]감소시킨다는 증거가 있다.

상호 작용

ARL2는 단백질 unc-119 상동체,^[10] TBCD^[11]^[12] ^[13]^[14]및 PDE6D와 상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000213465 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000024944 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clark J, Moore L, Krasinskas A, Way J, Battey J, Tamkun J, Kahn RA (November 1993). "Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8952–6. Bibcode:1993PNAS...90.8952C. doi:10.1073/pnas.90.19.8952. PMC 47479. PMID 8415637.
^ Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC (September 1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
^ ^a ^b "Entrez Gene: ARL2 ADP-ribosylation factor-like 2".
^ Hanke-Gogokhia, C.; Zhang, H.; Frederick, J. M.; Baehr, W. (2016). "The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors". Advances in Experimental Medicine and Biology. 854: 655–661. doi:10.1007/978-3-319-17121-0_87. ISBN 978-3-319-17120-3. PMID 26427472.
^ Newman, L. E.; Schiavon, C. R.; Turn, R. E.; Kahn, R. A. (2017). "The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space". Cellular Logistics. 7 (3): e1340104. doi:10.1080/21592799.2017.1340104. PMC 5602422. PMID 28944094.
^ Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G (January 2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1–3): 26–32. doi:10.1016/S0014-5793(02)03766-3. PMID 12527357. S2CID 22603052.
^ Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42): 40829–36. doi:10.1074/jbc.M308678200. PMID 12912990.
^ Bhamidipati A, Lewis SA, Cowan NJ (May 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5): 1087–96. doi:10.1083/jcb.149.5.1087. PMC 2174823. PMID 10831612.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.

외부 링크

UCSC Genome Browser의 인간 ARL2 게놈 위치 및 ARL2 유전자 세부 정보 페이지.

추가 정보

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bhamidipati A, Lewis SA, Cowan NJ (2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5): 1087–96. doi:10.1083/jcb.149.5.1087. PMC 2174823. PMID 10831612.
Sharer JD, Shern JF, Van Valkenburgh H, Wallace DC, Kahn RA (2002). "ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter". Mol. Biol. Cell. 13 (1): 71–83. doi:10.1091/mbc.01-05-0245. PMC 65073. PMID 11809823.
Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
Antoshechkin I, Han M (2002). "The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis". Dev. Cell. 2 (5): 579–91. doi:10.1016/S1534-5807(02)00146-6. PMID 12015966.
Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G (2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1–3): 26–32. doi:10.1016/S0014-5793(02)03766-3. PMID 12527357. S2CID 22603052.
Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42): 40829–36. doi:10.1074/jbc.M308678200. PMID 12912990.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA (2006). "Arl2 and Arl3 regulate different microtubule-dependent processes". Mol. Biol. Cell. 17 (5): 2476–87. doi:10.1091/mbc.E05-10-0929. PMC 1446103. PMID 16525022.
Beghin A, Honore S, Messana C, Matera EL, Aim J, Burlinchon S, Braguer D, Dumontet C (2007). "ADP ribosylation factor like 2 (Arl2) protein influences microtubule dynamics in breast cancer cells". Exp. Cell Res. 313 (3): 473–85. doi:10.1016/j.yexcr.2006.10.024. PMID 17188265.

이 단백질 관련 기사는 스텁입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000213465 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000024944 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8415637-5] Clark J, Moore L, Krasinskas A, Way J, Battey J, Tamkun J, Kahn RA (November 1993). "Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8952–6. Bibcode:1993PNAS...90.8952C. doi:10.1073/pnas.90.19.8952. PMC 47479. PMID 8415637.

[pmid9253601-6] Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC (September 1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.

[entrez-7] "Entrez Gene: ARL2 ADP-ribosylation factor-like 2".

[8] Hanke-Gogokhia, C.; Zhang, H.; Frederick, J. M.; Baehr, W. (2016). "The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors". Advances in Experimental Medicine and Biology. 854: 655–661. doi:10.1007/978-3-319-17121-0_87. ISBN 978-3-319-17120-3. PMID 26427472.

[9] Newman, L. E.; Schiavon, C. R.; Turn, R. E.; Kahn, R. A. (2017). "The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space". Cellular Logistics. 7 (3): e1340104. doi:10.1080/21592799.2017.1340104. PMC 5602422. PMID 28944094.

[pmid12527357-10] Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G (January 2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1–3): 26–32. doi:10.1016/S0014-5793(02)03766-3. PMID 12527357. S2CID 22603052.

[pmid12912990-11] Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42): 40829–36. doi:10.1074/jbc.M308678200. PMID 12912990.

[pmid10831612-12] Bhamidipati A, Lewis SA, Cowan NJ (May 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5): 1087–96. doi:10.1083/jcb.149.5.1087. PMC 2174823. PMID 10831612.

[pmid16189514-13] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid11980706-14] Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.

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Search

ARL2

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

외부 링크

추가 정보