STAGA 복합체 65 서브유닛 감마는 인간에서 SUPT7L 유전자에 의해 암호화 되는 단백질이다.[5] [6] [7]
모델 유기체 모델 유기체는 SUPT7L 기능 연구에 사용되어 왔다.Internationaltm1a(EUCOMM)Wtsi [13] [14] Knockout Mouse Consortium 프로그램 의 일부로서 Supt7l이라고 불리는 조건부 녹아웃 마우스 라인이 생성되었습니다.이것 은 질병 동물 모델을 생성하여 관심 있는 [15] [16] [17]
수컷과 암컷은 표준화된 표현형 검사를 통해 [11] [18] 돌연변이 생쥐에 대해 24개의 검사가 수행되었고 2개의 유의한 이상이 [11] 임신 기간 동안 동종 돌연변이 배아는 확인되지 않았고, 따라서 젖을 뺄 때까지 생존한 배아는 없었다. 나머지 테스트는 헤테로 접합 돌연변이 성인 생쥐를 대상으로 수행되었지만 더 이상의 이상은 [11]
상호 작용 SUPT7L은 TAF9 [6] 전사 개시 단백질 SPT3 호몰로그 와 [6] 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000119760 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000053134 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 5 (5): 277–86. doi :10.1093/dnares/5.5.277 PMID 9872452 . ^ a b c Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (October 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo" . Molecular and Cellular Biology . 21 (20): 6782–95. doi :10.1128/MCB.21.20.6782-6795.2001 . PMC 99856 PMID 11564863 . ^ "Entrez Gene: SUPT7L suppressor of Ty 7 (S. cerevisiae)-like" .^ "Dysmorphology data for Supt7l" . Wellcome Trust Sanger Institute.^ "Salmonella infection data for Supt7l" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Supt7l" . Wellcome Trust Sanger Institute.^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Wellcome Trust Sanger Institute의 마우스 리소스 포털.^ "International Knockout Mouse Consortium" .^ "Mouse Genome Informatics" .^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (June 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biology . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 . 추가 정보 Nishizaka S, Gomi S, Harada K, Oizumi K, Itoh K, Shichijo S (September 2000). "A new tumor-rejection antigen recognized by cytotoxic T lymphocytes infiltrating into a lung adenocarcinoma". Cancer Research . 60 (17): 4830–7. PMID 10987294 . Gocke CB, Yu H, Kang J (February 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates" . The Journal of Biological Chemistry . 280 (6): 5004–12. doi :10.1074/jbc.M411718200 PMID 15561718 . Wang HY, Peng G, Guo Z, Shevach EM, Wang RF (March 2005). "Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells" . Journal of Immunology . 174 (5): 2661–70. doi :10.4049/jimmunol.174.5.2661 PMID 15728473 . Soutoglou E, Demény MA, Scheer E, Fienga G, Sassone-Corsi P, Tora L (May 2005). "The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners" . Molecular and Cellular Biology . 25 (10): 4092–104. doi :10.1128/MCB.25.10.4092-4104.2005 . PMC 1087738 PMID 15870280 . 
