스텁1

스텁1
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	4KBQ
식별자
별칭	스텁1, 칩, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1, STIP1 호몰로지 및 단백질 1, SCA48이 포함된 U-box
외부 ID	OMIM: 607207 MGI: 1891731 호몰로진: 4281 GeneCard: STUB1
유전자 위치(인간)
쳇.	16번 염색체(인간)
끝	682,870bp
유전자 위치(마우스)
쳇.	17번 염색체(쥐)
끝	26,052,378 bp
RNA 표현 패턴
	표현된 상단
	중앙 후회; ; 외형구개팔리두스; ; 척추 갱년기; ; 상전정핵; ; 복측 티그먼트 영역; ; 부갑상샘; ; 깡충깡충 뛰다; ; 젖꼭지; ; 삼위일체; ; 신간문장;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	Hsp90 단백질 결합; 단백질-매크로몰리큘 어댑터 활동; 단백질 호모디메르화 활동; 잘못 접힌 단백질 결합; GO:1904264, GO:1904822, GO:0090622, GO:0090302 유비퀴틴 단백질 리기아제 활성; 유비쿼터스-유니버셜 트랜스퍼아제 활동; 유비퀴틴-시틴 리게아제 활동; 키나제 결합; GO:0001948 단백질 결합; 효소 결합; TPR 도메인 바인딩; G 단백질 결합 수용체 결합; 유비퀴틴 단백질 리가제 결합; 전이효소 활동; Hsp70 단백질 결합; SMAD 바인딩; 열충격 단백질 결합; 타우 단백질 결합; 샤프론 제본;
셀룰러 컴포넌트	세포질; 유비퀴틴 리가제 복합체; 핵종의; Z 디스크; 소포체성 망막; 핵포용기구; 세포외 외성체; 유비퀴틴 결합 효소 복합체; 핵의; 시토솔; 샤프론 콤플렉스;
생물학적 과정	샤페론 매개 단백질 복합체 어셈블리의 양성 조절; 단백질 안정 조절; 유비퀴틴 함유 단백질 카타볼릭 공정; 글루코코르티코이드 대사 과정 조절; 단백질 K63 연결 유비쿼터스화; 단백질 성숙; 단백질 다극화; 잘못 접히거나 불완전하게 합성된 단백질에 대한 단백질 품질 관리; 단백질 결합에 대한 부정적인 규제; 유비퀴틴 의존성 SMAD 단백질 카타볼라 공정; DNA 손상 자극에 대한 세포 반응; 내소성 망막 확장 단백질 반응; 유비쿼터스 인-유니버셜 트랜스퍼아제 활동에 대한 긍정적인 규제; 단백질의 편재; 단백질 편재에 대한 양성 조절; 프로테아소말 유비퀴틴-유니비틴-유니비 단백질 카타볼라 공정; DNA 수리; 프로테아솜 매개 유비퀴틴 단백질 카타볼릭 공정; 단백질 자기화; 잘못 접힌 단백질에 대한 세포 반응; ERBB2 신호 경로; 성장 인자 베타 수용체 신호 경로 변환에 대한 음의 조절; 유비쿼터스 의존적 OFT 경로; 허혈에 대한 반응; 열에 대한 세포 반응; 샤프론 매개 자동 포식; 저산소증에 대한 세포 반응;
	출처:아미고 / 퀵고
직교체
	10273
	56424
	ENSG00000103266
	ENSMUSG00000039615
	Q9UNE7
	Q9WUD1
	NM_005861; NM_001293197
	NM_019719
	NP_001280126; NP_005852
	NP_062693
	위키다타
인간 보기/편집	마우스 보기/편집

STUB1(StIP1 호몰로지, 단백질 1)은 단백질 CHIP(HSC70-Interaction 단백질의 C terminus)를 코딩하는 인간 유전자다.^[5]^[6]

함수

이 유전자에 의해 인코딩된 CHIP 단백질은 체세포 단백질 HSC70과 HSP70의 ATPase 활성과 결합하여 억제하며 HSC70-HSP70 기질 결합 주기의 전방 반응을 차단한다.^[6]또 칩은 E3 유비퀴틴 리가제 활성을 보유하고 있으며,^[7] 주로 샤페론 결합 오폴딩 단백질을 중심으로 유비쿼터스화를 촉진한다.

칩은 급성 스트레스 시 HSP70 유도를 향상시키고 스트레스 회복 과정 중에 이직률을 조정한다.이에 따라 칩은 스트레스와 회복 과정에서 체세포 분비를 조절해 단백질 자기중심주의를 유지하는 것으로 보인다.^[8]

STUB1의 돌연변이는 스피노세레벨라텍사스형 16을 유발한다.^[9]

상호작용

STUB1은 다음과 상호 작용하는 것으로 나타났다.

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000103266 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000039615 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: STUB1 STIP1 homology and U-box containing protein 1".
^ ^a ^b ^c ^d ^e ^f Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (Jun 1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions". Molecular and Cellular Biology. 19 (6): 4535–45. doi:10.1128/mcb.19.6.4535. PMC 104411. PMID 10330192.
^ Jiang J, Ballinger CA, Wu Y, Dai Q, Cyr DM, Höhfeld J, Patterson C (Nov 2001). "CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation". The Journal of Biological Chemistry. 276 (46): 42938–44. doi:10.1074/jbc.M101968200. PMID 11557750.
^ Qian SB, McDonough H, Boellmann F, Cyr DM, Patterson C (Mar 2006). "CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70". Nature. 440 (7083): 551–5. doi:10.1038/nature04600. PMC 4112096. PMID 16554822.
^ Synofzik M, Schüle R, Schulze M, Gburek-Augustat J, Schweizer R, Schirmacher A, Krägeloh-Mann I, Gonzalez M, Young P, Züchner S, Schöls L, Bauer P (2014). "Phenotype and frequency of STUB1 mutations: next-generation screenings in Caucasian ataxia and spastic paraplegia cohorts". Orphanet Journal of Rare Diseases. 9 (1): 57. doi:10.1186/1750-1172-9-57. PMC 4021831. PMID 24742043.
^ Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K (Dec 2008). "X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility". Nature Cell Biology. 10 (12): 1447–55. doi:10.1038/ncb1804. PMID 19011619. S2CID 6553549.
^ ^a ^b Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (Jul 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Molecular Cell. 10 (1): 55–67. doi:10.1016/s1097-2765(02)00583-x. PMID 12150907.
^ Li X, Huang M, Zheng H, Wang Y, Ren F, Shang Y, Zhai Y, Irwin DM, Shi Y, Chen D, Chang Z (Jun 2008). "CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation". The Journal of Cell Biology. 181 (6): 959–72. doi:10.1083/jcb.200711044. PMC 2426947. PMID 18541707.

추가 읽기

Patterson C (Jan 2002). "A new gun in town: the U box is a ubiquitin ligase domain". Science's STKE. 2002 (116): pe4. doi:10.1126/stke.2002.116.pe4. PMID 11805346. S2CID 31977936.
Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (Jun 1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions". Molecular and Cellular Biology. 19 (6): 4535–45. doi:10.1128/mcb.19.6.4535. PMC 104411. PMID 10330192.
Connell P, Ballinger CA, Jiang J, Wu Y, Thompson LJ, Höhfeld J, Patterson C (Jan 2001). "The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins". Nature Cell Biology. 3 (1): 93–6. doi:10.1038/35050618. PMID 11146632. S2CID 19161960.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (Feb 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Jiang J, Ballinger CA, Wu Y, Dai Q, Cyr DM, Höhfeld J, Patterson C (Nov 2001). "CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation". The Journal of Biological Chemistry. 276 (46): 42938–44. doi:10.1074/jbc.M101968200. PMID 11557750.
Demand J, Alberti S, Patterson C, Höhfeld J (Oct 2001). "Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling". Current Biology. 11 (20): 1569–77. doi:10.1016/S0960-9822(01)00487-0. PMID 11676916. S2CID 2021754.
Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (Jul 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Molecular Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P, Gribben JG (Sep 2002). "Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX". Blood. 100 (6): 2123–31. doi:10.1182/blood-2002-02-0513. PMID 12200376.
Cardozo CP, Michaud C, Ost MC, Fliss AE, Yang E, Patterson C, Hall SJ, Caplan AJ (Feb 2003). "C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation". Archives of Biochemistry and Biophysics. 410 (1): 134–40. doi:10.1016/S0003-9861(02)00680-X. PMID 12559985.
Zhou P, Fernandes N, Dodge IL, Reddi AL, Rao N, Safran H, DiPetrillo TA, Wazer DE, Band V, Band H (Apr 2003). "ErbB2 degradation mediated by the co-chaperone protein CHIP". The Journal of Biological Chemistry. 278 (16): 13829–37. doi:10.1074/jbc.M209640200. PMID 12574167.
Shimura H, Schwartz D, Gygi SP, Kosik KS (Feb 2004). "CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival". The Journal of Biological Chemistry. 279 (6): 4869–76. doi:10.1074/jbc.M305838200. PMID 14612456.
Li L, Xin H, Xu X, Huang M, Zhang X, Chen Y, Zhang S, Fu XY, Chang Z (Jan 2004). "CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription". Molecular and Cellular Biology. 24 (2): 856–64. doi:10.1128/MCB.24.2.856-864.2004. PMC 343794. PMID 14701756.
Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M (Apr 2004). "CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation". Human Molecular Genetics. 13 (7): 703–14. doi:10.1093/hmg/ddh083. PMID 14962978.
Galigniana MD, Harrell JM, Housley PR, Patterson C, Fisher SK, Pratt WB (Apr 2004). "Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation". Brain Research. Molecular Brain Research. 123 (1–2): 27–36. doi:10.1016/j.molbrainres.2003.12.015. PMID 15046863.
He B, Bai S, Hnat AT, Kalman RI, Minges JT, Patterson C, Wilson EM (Jul 2004). "An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP)". The Journal of Biological Chemistry. 279 (29): 30643–53. doi:10.1074/jbc.M403117200. PMID 15107424.
Alberti S, Böhse K, Arndt V, Schmitz A, Höhfeld J (Sep 2004). "The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator". Molecular Biology of the Cell. 15 (9): 4003–10. doi:10.1091/mbc.E04-04-0293. PMC 515335. PMID 15215316.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

외부 링크

UCSC 게놈 브라우저에서 STUB1 인간 유전자 위치.
UCSC 게놈 브라우저의 STUB1 인간 유전자 세부 정보.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000103266 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000039615 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STUB1 STIP1 homology and U-box containing protein 1".

[pmid10330192-6] ^ ^a ^b ^c ^d ^e ^f Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (Jun 1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions". Molecular and Cellular Biology. 19 (6): 4535–45. doi:10.1128/mcb.19.6.4535. PMC 104411. PMID 10330192.

[pmid11557750-7] Jiang J, Ballinger CA, Wu Y, Dai Q, Cyr DM, Höhfeld J, Patterson C (Nov 2001). "CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation". The Journal of Biological Chemistry. 276 (46): 42938–44. doi:10.1074/jbc.M101968200. PMID 11557750.

[pmid16554822-8] Qian SB, McDonough H, Boellmann F, Cyr DM, Patterson C (Mar 2006). "CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70". Nature. 440 (7083): 551–5. doi:10.1038/nature04600. PMC 4112096. PMID 16554822.

[Synofzik_2014-9] Synofzik M, Schüle R, Schulze M, Gburek-Augustat J, Schweizer R, Schirmacher A, Krägeloh-Mann I, Gonzalez M, Young P, Züchner S, Schöls L, Bauer P (2014). "Phenotype and frequency of STUB1 mutations: next-generation screenings in Caucasian ataxia and spastic paraplegia cohorts". Orphanet Journal of Rare Diseases. 9 (1): 57. doi:10.1186/1750-1172-9-57. PMC 4021831. PMID 24742043.

[pmid19011619-10] Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K (Dec 2008). "X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility". Nature Cell Biology. 10 (12): 1447–55. doi:10.1038/ncb1804. PMID 19011619. S2CID 6553549.

[pmid12150907-11] Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (Jul 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Molecular Cell. 10 (1): 55–67. doi:10.1016/s1097-2765(02)00583-x. PMID 12150907.

[pmid18541707-12] Li X, Huang M, Zheng H, Wang Y, Ren F, Shang Y, Zhai Y, Irwin DM, Shi Y, Chen D, Chang Z (Jun 2008). "CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation". The Journal of Cell Biology. 181 (6): 959–72. doi:10.1083/jcb.200711044. PMC 2426947. PMID 18541707.

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스텁1

네임스페이스

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목차

함수

상호작용

참조

추가 읽기

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