망막아세포종결합단백질8 은 RBBP8유전자 에 [5] [6] [7] 단백질 이다.
기능. 이 유전자에 의해 암호화된 단백질은 널리 발현되는 핵단백질이다. 그것은 세포 증식을 조절하는 망막아종 단백질과 직접 결합하는 여러 단백질 중에서 발견됩니다. 이 단백질은 전사공억제제 CTBP와 복합된다. 그것은 또한 BRCA1과 관련이 있으며 전사 조절, DNA 복구 및/또는 세포 주기 체크포인트 제어에서 BRCA1의 기능을 조절하는 것으로 생각된다. 이 유전자 자체가 BRCA1과 같은 경로에서 작용하는 종양 억제제일 수 있다. 이 유전자에 대해 두 개의 다른 동질 형태를 코드하는 세 개의 전사 변형이 발견되었다. 더 많은 트랜스크립트 베리에이션이 존재하지만, 그 풀렝스의 성질은 [7]
상호 작용 RBBP8은 다음과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000101773 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000041238 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c d Fusco C, Reymond A, Zervos AS (October 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics . 51 (3): 351–8. doi :10.1006/geno.1998.5368 . PMID 9721205 . ^ Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP (November 2007). "Human CtIP promotes DNA end resection" . Nature . 450 (7169): 509–14. doi :10.1038/nature06337 . PMC 2409435 PMID 17965729 . ^ a b "Entrez Gene: RBBP8 retinoblastoma binding protein 8" .^ a b Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH (July 2000). "Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response". Nature . 406 (6792): 210–5. doi :10.1038/35018134 . PMID 10910365 . S2CID 3266654 . ^ Kim ST, Lim DS, Canman CE, Kastan MB (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members" . J. Biol. Chem . 274 (53): 37538–43. doi :10.1074/jbc.274.53.37538 PMID 10608806 . ^ a b Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH (April 1999). "Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage" . J. Biol. Chem . 274 (16): 11334–8. doi :10.1074/jbc.274.16.11334 PMID 10196224 . ^ Rodriguez M, Yu X, Chen J, Songyang Z (Dec 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains" . J. Biol. Chem . 278 (52): 52914–8. doi :10.1074/jbc.C300407200 PMID 14578343 . ^ Wong AK, Ormonde PA, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian SV, Teng DH, Bartel PL (November 1998). "Characterization of a carboxy-terminal BRCA1 interacting protein" . Oncogene . 17 (18): 2279–85. doi :10.1038/sj.onc.1202150 PMID 9811458 . ^ Wu-Baer F, Baer R (November 2001). "Effect of DNA damage on a BRCA1 complex". Nature . 414 (6859): 36. doi :10.1038/35102118 . PMID 11689934 . S2CID 4329675 . ^ Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R (September 1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression" . J. Biol. Chem . 273 (39): 25388–92. doi :10.1074/jbc.273.39.25388 PMID 9738006 . ^ Yu X, Baer R (June 2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor" . J. Biol. Chem . 275 (24): 18541–9. doi :10.1074/jbc.M909494199 PMID 10764811 . ^ Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G (April 1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif" . J. Biol. Chem . 273 (15): 8549–52. doi :10.1074/jbc.273.15.8549 PMID 9535825 . ^ Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE (March 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity" . J. Biol. Chem . 277 (10): 7849–56. doi :10.1074/jbc.M110603200 PMID 11751867 . ^ Sutherland KD, Visvader JE, Choong DY, Sum EY, Lindeman GJ, Campbell IG (October 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas" . Int. J. Cancer . 107 (1): 155–8. doi :10.1002/ijc.11343 PMID 12925972 . S2CID 20908722 . ^ Dick FA, Sailhamer E, Dyson NJ (May 2000). "Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins" . Mol. Cell. Biol . 20 (10): 3715–27. doi :10.1128/mcb.20.10.3715-3727.2000 . PMC 85672 PMID 10779361 . ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . ^ Meloni AR, Smith EJ, Nevins JR (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor" . Proc. Natl. Acad. Sci. U.S.A . 96 (17): 9574–9. doi :10.1073/pnas.96.17.9574 PMC 22250 PMID 10449734 . ^ Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H (Dec 2003). "SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway" . Oncogene . 22 (55): 8845–51. doi :10.1038/sj.onc.1206994 PMID 14654780 . 추가 정보 Deng CX, Brodie SG (2000). "Roles of BRCA1 and its interacting proteins". BioEssays . 22 (8): 728–37. doi :10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B . PMID 10918303 . Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene . 146 (2): 199–207. doi :10.1016/0378-1119(94)90293-3 . PMID 8076819 . Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G (1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif" . J. Biol. Chem . 273 (15): 8549–52. doi :10.1074/jbc.273.15.8549 PMID 9535825 . Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R (1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression" . J. Biol. Chem . 273 (39): 25388–92. doi :10.1074/jbc.273.39.25388 PMID 9738006 . Wong AK, Ormonde PA, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian SV, Teng DH, Bartel PL (1998). "Characterization of a carboxy-terminal BRCA1 interacting protein" . Oncogene . 17 (18): 2279–85. doi :10.1038/sj.onc.1202150 PMID 9811458 . Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH (1999). "Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage" . J. Biol. Chem . 274 (16): 11334–8. doi :10.1074/jbc.274.16.11334 PMID 10196224 . Meloni AR, Smith EJ, Nevins JR (1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor" . Proc. Natl. Acad. Sci. U.S.A . 96 (17): 9574–9. doi :10.1073/pnas.96.17.9574 PMC 22250 PMID 10449734 . Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members" . J. Biol. Chem . 274 (53): 37538–43. doi :10.1074/jbc.274.53.37538 PMID 10608806 . Yu X, Baer R (2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor" . J. Biol. Chem . 275 (24): 18541–9. doi :10.1074/jbc.M909494199 PMID 10764811 . Dick FA, Sailhamer E, Dyson NJ (2000). "Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral Oncoproteins" . Mol. Cell. Biol . 20 (10): 3715–27. doi :10.1128/MCB.20.10.3715-3727.2000 . PMC 85672 PMID 10779361 . Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB J . 14 (7): 904–12. doi :10.1096/fasebj.14.7.904 . PMID 10783144 . S2CID 43175069 . Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH (2000). "Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response". Nature . 406 (6792): 210–5. doi :10.1038/35018134 . PMID 10910365 . S2CID 3266654 . Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH (2000). "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1" . Mol. Cell . 6 (4): 757–68. doi :10.1016/S1097-2765(00)00075-7 PMID 11090615 . Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H (2001). "The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling" . Blood . 97 (9): 2815–22. doi :10.1182/blood.V97.9.2815 PMID 11313276 . Melhuish TA, Gallo CM, Wotton D (2001). "TGIF2 interacts with histone deacetylase 1 and represses transcription" . J. Biol. Chem . 276 (34): 32109–14. doi :10.1074/jbc.M103377200 PMID 11427533 . Wu-Baer F, Baer R (2001). "Effect of DNA damage on a BRCA1 complex". Nature . 414 (6859): 36. doi :10.1038/35102118 . PMID 11689934 . S2CID 4329675 . Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity" . J. Biol. Chem . 277 (10): 7849–56. doi :10.1074/jbc.M110603200 PMID 11751867 . Koipally J, Georgopoulos K (2002). "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression" . J. Biol. Chem . 277 (26): 23143–9. doi :10.1074/jbc.M202079200 PMID 11959865 . 
