POU2AF1

POU2AF1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1CQT
식별자
에일리어스	POU2AF1, BOB1, OBF-1, OCAB, POU 클래스 2 연결 인자 1, POU 클래스 2 호메오박스 연결 인자 1
외부 ID	OMIM : 601206 MGI : 105086 HomoloGene : 4543 GenCard : POU2AF1
유전자 위치(인간)
크르.	11번 염색체(인간)
끝.	111,455,630 bp
유전자 위치(마우스)
크르.	9번 염색체(쥐)
끝.	51,480,380 bp
RNA발현패턴
	상단 표시 위치:
	유문; ; 카디아; ; 비장; ; 림프절; ; 부록; ; 기관지 상피 세포; ; 흉선; ; 골수 세포; ; 결석골; ; 십이지장;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; GO:0001105 트랜스크립션코액티베이터 액티비티; GO:0001948 단백질 결합; GO:0001104 트랜스크립션코어레이터 액티비티; RNA중합효소II 코어프로모터배열특이적 DNA결합; GO:0000980 RNA중합효소II 시스조절영역배열특이적 DNA결합;
셀룰러 컴포넌트	핵; RNA중합효소II전사조절복합체;
생물학적 과정	전사조절, DNA템플릿화; 체액성 면역 반응; RNA중합효소II에 의한 전사; 전사, DNA 템플릿; RNA중합효소II에 의한 전사의 양성 조절;
	출처:아미고 / QuickGO
맞춤법
	5450
	18985
	ENSG00000110777
	ENSMUSG000032053
	문제 16633
	Q64693
	NM_006235
	NM_011136
	NP_006226
	NP_035266
	위키데이터
인간 보기/편집	마우스 표시/편집

POU 도메인 클래스 2 관련인자 1은 POU2AF1 ^[5]^[6]유전자에 의해 인체 내에서 암호화되는 단백질이다.단백질은 또한 B 세포(즉, OCAB), Oct 결합 인자 1(OBF1 또는 OBF-1), 그리고 문헌에서 일반적으로 발견되는 바와 같이 ^[7]BOB1로 불린다.BOB1은 주로 B세포 림프구에 의해 발현되는 전사공활성제(즉 전사인자의 활성을 제어하는 단백질)이며 CD20, CRISP-3 및 CD36의 ^[8]이러한 세포 발현에 중요한 면역글로불린 및 기타 유전자를 제어한다.BOB1의 발현은 B-세포 ^[9]림프종으로서 특정 림프종을 식별하는데 유용한 것으로 입증되었으며,^[10] 이는 BAB1 발현을 사용하여 림프종이 확산성 대형 B-세포 림프종임을 식별하는 데 도움을 주는 연구에서 예시되었다.

상호 작용

POU2AF1은 다음과 상호작용하는 것으로 나타났습니다.

POU2F1^[11]^[12]^[13] 및
SIAH1.^[14]^[15]

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000110777 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032053 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501.
^ "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1".
^ https://www.ncbi.nlm.nih.gov/gene?term=(ocab [ gen ]%20 AND%20 ( Homo % 20 sapiens [ orgn ]%20 AND%20 live [ prop ]%20 NOT%20 new entry [ gene ]&sort = weight
^ Ponzoni M, Arrigoni G, Doglioni C (January 2007). "New transcription factors in diagnostic hematopathology". Advances in Anatomic Pathology. 14 (1): 25–35. doi:10.1097/PAP.0b013e31802f0495. PMID 17198308. S2CID 37644377.
^ Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z (November 2016). "Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers". Histopathology. 69 (5): 775–783. doi:10.1111/his.13017. PMID 27319306. S2CID 12613073.
^ Grimm KE, O'Malley DP (February 2019). "Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues". Annals of Diagnostic Pathology. 38: 6–10. doi:10.1016/j.anndiagpath.2018.09.014. PMID 30380402. S2CID 53196244.
^ Chasman D, Cepek K, Sharp PA, Pabo CO (Oct 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.
^ Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (Jan 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.
^ Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (Jun 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252.
^ Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P (Aug 2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMC 149178. PMID 11483517.
^ Jahn L, Hombrink P, Hagedoorn RS, Kester MG, van der Steen DM, Rodriguez T, Pentcheva-Hoang T, de Ru AH, Schoonakker MP, Meeuwsen MH, Griffioen M, van Veelen PA, Falkenburg JH, Heemskerk MH (March 2017). "TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1". Blood. 129 (10): 1284–1295. doi:10.1182/blood-2016-09-737536. PMID 28053195.

추가 정보

Teitell MA (2004). "OCA-B regulation of B-cell development and function". Trends Immunol. 24 (10): 546–53. doi:10.1016/j.it.2003.08.002. PMID 14552839.
Luo Y, Roeder RG (1995). "Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B". Mol. Cell. Biol. 15 (8): 4115–24. doi:10.1128/MCB.15.8.4115. PMC 230650. PMID 7623806.
Gstaiger M, Knoepfel L, Georgiev O, Schaffner W, Hovens CM (1995). "A B-cell coactivator of octamer-binding transcription factors". Nature. 373 (6512): 360–2. Bibcode:1995Natur.373..360G. doi:10.1038/373360a0. PMID 7779176. S2CID 4303288.
Strubin M, Newell JW, Matthias P (1995). "OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins". Cell. 80 (3): 497–506. doi:10.1016/0092-8674(95)90500-6. PMID 7859290. S2CID 6139601.
Galiègue-Zouitina S, Quief S, Hildebrand MP, Denis C, Lecocq G, Collyn-d'Hooghe M, Bastard C, Yuille M, Dyer MJ, Kerckaert JP (1996). "Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation". Comptes Rendus de l'Académie des Sciences, Série III. 318 (11): 1125–31. PMID 8574789.
Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T (1997). "Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells". Science. 277 (5323): 221–5. doi:10.1126/science.277.5323.221. PMID 9211847.
Sauter P, Matthias P (1998). "The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction". Immunobiology. 198 (1–3): 207–16. doi:10.1016/S0171-2985(97)80041-1. PMID 9442392.
Luo Y, Ge H, Stevens S, Xiao H, Roeder RG (1998). "Coactivation by OCA-B: Definition of Critical Regions and Synergism with General Cofactors". Mol. Cell. Biol. 18 (7): 3803–10. doi:10.1128/mcb.18.7.3803. PMC 108964. PMID 9632764.
Sauter P, Matthias P (1998). "Coactivator OBF-1 Makes Selective Contacts with Both the POU-Specific Domain and the POU Homeodomain and Acts as a Molecular Clamp on DNA". Mol. Cell. Biol. 18 (12): 7397–409. doi:10.1128/MCB.18.12.7397. PMC 109321. PMID 9819426.
Chasman D, Cepek K, Sharp PA, Pabo CO (1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.
Tomilin A, Reményi A, Lins K, Bak H, Leidel S, Vriend G, Wilmanns M, Schöler HR (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell. 103 (6): 853–64. doi:10.1016/S0092-8674(00)00189-6. PMID 11136971. S2CID 14650955.
Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252.
Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P (2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMC 149178. PMID 11483517.
Boehm J, He Y, Greiner A, Staudt L, Wirth T (2001). "Regulation of BOB.1/OBF.1 stability by SIAH". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMC 149152. PMID 11483518.
Malone CS, Wall R (2002). "Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters". J. Immunol. 168 (7): 3369–75. doi:10.4049/jimmunol.168.7.3369. PMID 11907094.
Casellas R, Jankovic M, Meyer G, Gazumyan A, Luo Y, Roeder R, Nussenzweig M (2003). "OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes". Cell. 110 (5): 575–85. doi:10.1016/S0092-8674(02)00911-X. PMID 12230975. S2CID 17887117.
Schaffer A, Kim EC, Wu X, Zan H, Testoni L, Salamon S, Cerutti A, Casali P (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". J. Biol. Chem. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812.
Lins K, Reményi A, Tomilin A, Massa S, Wilmanns M, Matthias P, Schöler HR (2003). "OBF1 enhances transcriptional potential of Oct1". EMBO J. 22 (9): 2188–98. doi:10.1093/emboj/cdg199. PMC 156071. PMID 12727885.

인간 염색체 11번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000110777 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000032053 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8617501-5] Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501.

[entrez-6] "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1".

[7] ttps://www.ncbi.nlm.nih.gov/gene?term=(ocab [ gen ]%20 AND%20 ( Homo % 20 sapiens [ orgn ]%20 AND%20 live [ prop ]%20 NOT%20 new entry [ gene ]&sort = weight

[pmid17198308-8] Ponzoni M, Arrigoni G, Doglioni C (January 2007). "New transcription factors in diagnostic hematopathology". Advances in Anatomic Pathology. 14 (1): 25–35. doi:10.1097/PAP.0b013e31802f0495. PMID 17198308. S2CID 37644377.

[pmid27319306-9] Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z (November 2016). "Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers". Histopathology. 69 (5): 775–783. doi:10.1111/his.13017. PMID 27319306. S2CID 12613073.

[pmid30380402-10] Grimm KE, O'Malley DP (February 2019). "Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues". Annals of Diagnostic Pathology. 38: 6–10. doi:10.1016/j.anndiagpath.2018.09.014. PMID 30380402. S2CID 53196244.

[pmid10541551-11] Chasman D, Cepek K, Sharp PA, Pabo CO (Oct 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.

[pmid9418884-12] Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (Jan 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.

[pmid11380252-13] Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (Jun 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252.

[pmid11483517-14] Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P (Aug 2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMC 149178. PMID 11483517.

[pmid28053195-15] Jahn L, Hombrink P, Hagedoorn RS, Kester MG, van der Steen DM, Rodriguez T, Pentcheva-Hoang T, de Ru AH, Schoonakker MP, Meeuwsen MH, Griffioen M, van Veelen PA, Falkenburg JH, Heemskerk MH (March 2017). "TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1". Blood. 129 (10): 1284–1295. doi:10.1182/blood-2016-09-737536. PMID 28053195.

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POU2AF1

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상호 작용

레퍼런스

추가 정보