PICK1

PICK1
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	2GZV
식별자
별칭	PICKCA 1과 상호작용하는 PICKABP, 단백질
외부 ID	OMIM: 605926 MGI: 894645 HomoloGene: 7470 GeneCard: PICK1
유전자 위치(인간)
쳇.	22번 염색체(인간)
끝	38,075,701 bp
유전자 위치(마우스)
쳇.	15번 염색체(쥐)
끝	79,1994 bp
RNA 표현 패턴
	표현된 상단
	전방 뇌하수체; ; 오른쪽 자궁관; ; 위 점막; ; 췌장체; ; 갑상선의 우엽; ; 경조 침샘; ; 갑상선 좌엽; ; 복부 피부; ; 오른쪽 폐; ; 수근신경;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	단백질 영역별 결합; Arp2/3 복합 바인딩; 금속 이온 결합; 액틴 필라멘트 바인딩; 단백질 C-단자 결합; GO:0001948 단백질 결합; 동일한 단백질 결합; 효소 결합; 구속력을 행사하다; 신호 수용체 결합; G 단백질 결합 수용체 결합; 단백질 키나아제 C 결합; 인광 결합;
셀룰러 컴포넌트	세포질; 내피막; 시냅스 후 막; 골지 기구; GO:0097483, GO:0097481 시냅스 후 밀도; 막으로 막다; 플라즈마 막; 시냅스; 세포 접합; 세포질 과핵 지역; 뉴런 투영법; 시토스켈레톤; 사전 시냅스 막; 미토콘드리온; 시토솔; 농업의; 시냅스성 방실; 전골기 망막; 시냅스 후 조기 내시경;
생물학적 과정	포도당 기아에 대한 세포 반응; 글리알 세포 발달; 복강낭 매개 수송, 골지부터 소포체 망막까지; 수용체 내장의 양성 조절; 뉴런 이온 채널 클러스터링; Arp2/3 복합 매개 액틴 핵의 조절; 모노아민 수송; 수용체 군집화; 생식세포 생성에 관여하는 DNA 메틸레이션; Arp2/3 복합 매개 액틴 핵의 음성 조절; 등뼈 조직; 척추 유지; 단백질 인산화; 단백질 키나제 C 활성화 G 단백질 결합 수용체 신호 경로; 장기 시냅스 우울증; 감소된 산소 농도에 대한 세포 반응; 배아 발달에 관여하는 DNA 메틸화; 세포내 단백질 운반;
	출처:아미고 / 퀵고
직교체
	9463
	18693
	ENSG00000100151
	ENSMUSG00000068206
	Q9NRD5
	Q62083년
	NM_001039583; NM_001039584; NM_012407
	NM_001045558; NM_008837
NP_001034672; NP_001034673; NP_036539; NP_001034672.1; NP_001034673.1;
	NP_036539.1
	n/a
	위키다타
인간 보기/편집	마우스 보기/편집

C 키나아제와 상호작용하는 단백질 - 1은 인간에게 PICK1 유전자에 의해 암호화된 단백질이다.^[5]^[6]

함수

이 유전자에 의해 인코딩된 단백질은 PDZ 도메인을 포함하며, 이를 통해 단백질 키나아제 C, 알파(PRKCA)와 상호작용한다.이 단백질은 다양한 막단백질의 세포하 국산화 작용과 결합하고 조직화하는 어댑터의 기능을 할 수 있다.다발성 글루탐산 수용체 서브타입체, 모노아민 혈장막 전달체, 비전압 게이트 나트륨 통로 등과 상호작용하는 것으로 나타났으며, 이러한 막단 단백질에 PRKCA를 표적으로 하여 그 분포와 기능을 조절할 수 있다.이 단백질은 리간드 특유의 방식으로 PRKCA를 미토콘드리아로 구체적으로 표적으로 하는 앵커링 단백질 역할도 하는 것으로 밝혀졌다.이 유전자에 대해 동일한 단백질을 인코딩하는 세 가지 대본 변형이 발견되었다.^[7]

상호작용

PICK1은 다음과 상호 작용하는 것으로 나타났다.

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000100151 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000068206 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dev KK, Nishimune A, Henley JM, Nakanishi S (July 1999). "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits". Neuropharmacology. 38 (5): 635–44. doi:10.1016/S0028-3908(98)00230-5. PMID 10340301. S2CID 20472140.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
^ "Entrez Gene: PICK1 protein interacting with PRKCA 1".
^ Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970.
^ ^a ^b Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (February 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.
^ Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (April 2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron. 30 (1): 121–34. doi:10.1016/s0896-6273(01)00267-7. PMID 11343649.
^ ^a ^b ^c ^d ^e Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
^ ^a ^b Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron. 37 (4): 625–38. doi:10.1016/s0896-6273(02)01191-1. PMC 3314502. PMID 12597860.
^ Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP (May 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.
^ Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (October 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. doi:10.1523/JNEUROSCI.20-19-07252.2000. PMC 6772771. PMID 11007882.

추가 읽기

Collingridge GL, Isaac JT (2003). "Functional roles of protein interactions with AMPA and kainate receptors". Neurosci. Res. 47 (1): 3–15. doi:10.1016/S0168-0102(03)00160-3. PMID 12941441. S2CID 22572652.
Xu J, Xia J (2006). "Structure and function of PICK1". Neurosignals. 15 (4): 190–201. doi:10.1159/000098482. PMID 17215589.
Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson EN (1995). "PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system" (PDF). J. Cell Biol. 128 (3): 263–71. doi:10.1083/jcb.128.3.263. PMC 2120344. PMID 7844141.
Staudinger J, Lu J, Olson EN (1998). "Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha". J. Biol. Chem. 272 (51): 32019–24. doi:10.1074/jbc.272.51.32019. PMID 9405395.
Xia J, Zhang X, Staudinger J, Huganir RL (1999). "Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1". Neuron. 22 (1): 179–87. doi:10.1016/S0896-6273(00)80689-3. PMID 10027300.
Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD (1999). "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands". Neuron. 21 (6): 1453–63. doi:10.1016/S0896-6273(00)80663-7. PMID 9883737.
Takeya R, Takeshige K, Sumimoto H (2000). "Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors". Biochem. Biophys. Res. Commun. 267 (1): 149–55. doi:10.1006/bbrc.1999.1932. PMID 10623590.
Cowan CA, Yokoyama N, Bianchi LM, Henkemeyer M, Fritzsch B (2000). "EphB2 guides axons at the midline and is necessary for normal vestibular function". Neuron. 26 (2): 417–30. doi:10.1016/S0896-6273(00)81174-5. PMID 10839360.
Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (2001). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. doi:10.1523/JNEUROSCI.20-19-07252.2000. PMC 6772771. PMID 11007882.
Lin WJ, Chang YF, Wang WL, Huang CY (2001). "Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1". Biochem. J. 354 (Pt 3): 635–43. doi:10.1042/0264-6021:3540635. PMC 1221695. PMID 11237868.
Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP (2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.
Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron. 30 (1): 121–34. doi:10.1016/S0896-6273(01)00267-7. PMID 11343649.
Lin SH, Arai AC, Wang Z, Nothacker HP, Civelli O (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. doi:10.1124/mol.60.5.916. PMID 11641419. S2CID 9613515.
Duggan A, Garcia-Anoveros J, Corey DP (2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons". J. Biol. Chem. 277 (7): 5203–8. doi:10.1074/jbc.M104748200. PMID 11739374.
Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.
Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
Perroy J, El Far O, Bertaso F, Pin JP, Betz H, Bockaert J, Fagni L (2002). "PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7". EMBO J. 21 (12): 2990–9. doi:10.1093/emboj/cdf313. PMC 126066. PMID 12065412.
Jansen AM, Nässel DR, Madsen KL, Jung AG, Gether U, Kjaerulff O (2009). "PICK1 expression in the Drosophila nervous system primarily occurs in the nervous system". J. Comp. Neurol. 517 (3): 313–322. doi:10.1002/cne.22155. PMID 19757495. S2CID 205680305.

외부 링크

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000100151 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000068206 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10340301-5] Dev KK, Nishimune A, Henley JM, Nakanishi S (July 1999). "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits". Neuropharmacology. 38 (5): 635–44. doi:10.1016/S0028-3908(98)00230-5. PMID 10340301. S2CID 20472140.

[pmid10591208-6] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.

[entrez-7] "Entrez Gene: PICK1 protein interacting with PRKCA 1".

[pmid12578970-8] Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970.

[pmid11802773-9] Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (February 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.

[pmid11343649-10] Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (April 2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron. 30 (1): 121–34. doi:10.1016/s0896-6273(01)00267-7. PMID 11343649.

[pmid11891216-11] Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.

[pmid12597860-12] Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron. 37 (4): 625–38. doi:10.1016/s0896-6273(02)01191-1. PMC 3314502. PMID 12597860.

[pmid11278603-13] Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP (May 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.

[pmid11007882-14] Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (October 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. doi:10.1523/JNEUROSCI.20-19-07252.2000. PMC 6772771. PMID 11007882.

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PICK1

네임스페이스

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목차

함수

상호작용

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