PARD3

PARD3
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2KOM
식별자
에일리어스	PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, PAR-3 패밀리 셀 극성 조절기
외부 ID	OMIM: 606745 MGI: 2135608 HomoloGene: 10489 GeneCard: PARD3
유전자 위치(인간)
크르.	10번 염색체(인간)
끝.	34,815,190 bp
유전자 위치(마우스)
크르.	8번 염색체(쥐)
끝.	128,338,767 bp
RNA발현패턴
	상단 표시 위치:
	이차 난모세포; ; 복부 피부; ; 니플; ; 아킬레스건; ; 내장글로부페리더스; ; 위점막; ; 상부 신경; ; 위근; ; 랑게르한스 섬; ; 질;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	포스파티딜이노시톨-3-인산결합; GO:0001948 단백질 결합; 포스파티딜이노시톨-4,5-이인산결합; 단백질인산가수분해효소결합; 포스파티딜이노시톨-3,4,5-트리인산결합; 지질 결합; 동일단백질결합; 포스파티딜이노시톨결합;
셀룰러 컴포넌트	세포질; 세포; 막; 세포-세포 접합; 이세포밀접합; 혈장막; 축삭 성장 원뿔; 축삭간부; 세포 접합; 신경세포체; 세포 피질; 세포골격; 내막계; 아데렌스 접합; 단백질 함유 복합체; 꼭대기 플라즈마막; 첨접 복합체;
생물학적 과정	상피세포 극성 확립; 세포 분화; 축삭 형성; 막표적단백질; 펩티딜트레오닌인산화음성조절; 말초 신경계의 골수화; 세포 분열; 세포 극성의 확립 또는 유지; 골수화 양성 조절; 세포 국재 조절; 단백질인산화효소C활성화G단백질결합수용체신호경로; 비대칭 세포 분열; 이세포밀접합체; 세포 주기; 형질전환성장인자β수용체신호경로; 단백질 함유 복합체 조립체; 미소관세포골격조직; 세포 접착; 단백질 국재; 세포극성 확립; 상피세포의 단상극성 또는 단상극성 유지; 중심체 국재 확립;
	출처:아미고 / QuickGO
맞춤법
	56288
	93742
	ENSG00000148498
	ENSMUSG000025812
	Q8TEW0
	Q99NH2
NM_001184785; NM_001184786; NM_001184787; NM_001184788; NM_001184789;
	NM_001184790; NM_001184791; NM_001184792; NM_001184793; NM_001184794; NM_019619
NM_001013580; NM_001013581; NM_00112850; NM_033620; NM_001309391;
	NM_001309392; NM_001363431; NM_001363432
NP_001171714; NP_001171715; NP_001171716; NP_001171717; NP_001171718;
	NP_001171719; NP_001171720; NP_001171721; NP_001171722; NP_001171723; NP_062565
NP_001013598; NP_001013599; NP_001116322; NP_001296320; NP_001296321;
	NP_296369; NP_001350360; NP_001350361
	위키데이터
인간 보기/편집	마우스 표시/편집

결함 3 상동성분할은 인간에서 PARD3 ^[5]^[6]유전자에 의해 암호화되는 단백질이다.

기능.

C. elegans에서 처음 확인된 PARD 단백질은 비대칭 세포 분열과 분극 성장에 필수적인 반면 CDC42(MIM 116952)는 세포 극성의 확립을 매개한다.CDC42 GTPase는 뉴클레오티드 교환인자(GEFs; MIM 606057 참조)와 GTPase 활성화 단백질(GAPs; MIM 604980 참조)에 의해 제어되며, 일반적으로 CDC42/RAC(MIM 602048) 상호작용 도메인(CRIB)을 포함하는 많은 이펙터 단백질 세트와 상호작용한다.[OMIM ^[6]제공]

상호 작용

PARD3는 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000148498 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025812 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
^ ^a ^b "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)".
^ ^a ^b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (Oct 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187.
^ Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (Feb 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.

추가 정보

Johansson A, Driessens M, Aspenström P (2000). "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1". J. Cell Sci. 113 (18): 3267–75. doi:10.1242/jcs.113.18.3267. PMID 10954424.
Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, Akimoto K, Izumi Y, Ohnishi T, Ohno S (2001). "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures". J. Cell Biol. 152 (6): 1183–96. doi:10.1083/jcb.152.6.1183. PMC 2199212. PMID 11257119.
Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C." Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. S2CID 8789941.
Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, Vestweber D (2001). "The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)". EMBO J. 20 (14): 3738–48. doi:10.1093/emboj/20.14.3738. PMC 125258. PMID 11447115.
Fang CM, Xu YH (2002). "Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas". Cell Res. 11 (3): 223–9. doi:10.1038/sj.cr.7290090. PMID 11642408.
Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.
Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. PMID 12650946.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Liu XF, Ishida H, Raziuddin R, Miki T (2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMC 444862. PMID 15254234.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.

인간 10번 염색체의 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000148498 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000025812 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10934474-5] Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.

[entrez-6] "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)".

[pmid12953056-7] Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (Oct 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.

[pmid12459187-8] Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187.

[pmid12515806-9] Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (Feb 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.

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PARD3

네임스페이스

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목차

기능.

상호 작용

레퍼런스

추가 정보