DAB2

DAB2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2LSW
식별자
에일리어스	DAB2, DOC-2, DOC2, Clathrin 어댑터 단백질, DAB 어댑터 단백질 2
외부 ID	OMIM: 601236 MGI: 109175 HomoloGene: 1026 GeneCard: DAB2
유전자 위치(인간)
크르.	5번 염색체(인간)
끝.	39,462,300 bp
유전자 위치(마우스)
크르.	15번 염색체(쥐)
끝.	6,190,190 bp
RNA발현패턴
	상단 표시 위치:
	부고환 카푸트; ; 부고환 말뭉치; ; 태반; ; 활액관절; ; 아킬레스건; ; 신장; ; 활막; ; 좌부신; ; 신장수질; ; 생식 상피;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	클라트린 어댑터 활성; 단백질C말단결합; GO:0001948 단백질 결합; 화물수용체활성; SMAD 바인딩;
셀룰러 컴포넌트	세포질; 세포막내소기관; 막; 국소 접착; 혈장막; 리소좀막; 핵소체; 클라트린소포막; 클라트린 피팅; 세포외 엑소좀; GO:0016023 세포질 소포; 클라트린 소포; 섬유 중심; 세포;
생물학적 과정	형질전환성장인자β수용체신호경로의 양성조절; 세포 분화; 단백질인산화양조절; 엔도사이토증; 세포 이동의 양성 조절; 경로제한SMAD단백질인산화양성조절; 안드로겐수용체신호경로음성조절; 아포토시스 과정의 음성 조절; Wnt 시그널링 패스; 단백질 결합의 음성 조절; 간엽 전이 상피 양성 조절; 첨단 세포 분화; 다세포 생물 발달; 전사의 양성 조절, DNA 템플릿화; 엔도사이토시스 양성 조절; 혈장막 단백질 국재 음성 조절; 클라트린 의존성 엔도사이토시스 양성 조절; 단백질 수송; 초기 엔도솜에서 후기 엔도솜으로의 양성 조절; 인테그린결합신호경로; Wnt 시그널링 경로의 양성 조절, 평면 세포 극성 경로; 세포군 증식; 전사 음성 조절, DNA 템플릿; 표준 Wnt 시그널링 경로의 음성; 프로테아좀유비퀴틴의존성단백질이화과정양조절; SMAD 단백질 신호 전달의 양성 조절; 아포토시스 과정; 수용체유도세포증; 막구성; 운송;
	출처:아미고 / QuickGO
맞춤법
	1601
	13132
	ENSG00000153071
	ENSMUSG000022150
	P98082
	P98078
	NM_001343; NM_001244871
	NM_001008702; NM_001037905; NM_001102400; NM_023118; NM_001310446
	NP_001231800; NP_001334
	NP_001008702; NP_001032994; NP_001095870; NP_001297375; NP_075607
	위키데이터
인간 보기/편집	마우스 표시/편집

장애 호몰로그 2는 DAB2 ^[5]^[6]유전자에 의해 인간에게 암호화되는 단백질이다.

기능.

DAB2 mRNA는 정상적인 난소 상피 세포에서 발현되지만, 난소암 세포주에서는 하향 조절되거나 존재하지 않는다.770-아미노산 예측 단백질은 추정 마이트겐 응답 인단백질인 마우스 p96 단백질과 전체 83%의 동일성을 가지고 있으며, 호몰로지는 포스포티로신 상호작용 도메인에 해당하는 영역에서 단백질의 아미노 말단 말단에서 가장 강하다.DAB2의 하향 조절은 난소 발암에 중요한 역할을 할 수 있다.이 유전자는 처음에 DOC2(난소암에서 다르게 발현된 경우)로 명명되었으며 DOC2A 및 DOC2B 유전자(이중 C2 유사 도메인인 경우 알파 및 베타)^[7]와 구별된다.

상호 작용

DAB2는 다음 부품과 상호 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000153071 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022150 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albertsen HM, Smith SA, Melis R, Williams B, Holik P, Stevens J, White R (January 1997). "Sequence, genomic structure, and chromosomal assignment of human DOC-2". Genomics. 33 (2): 207–13. doi:10.1006/geno.1996.0185. PMID 8660969.
^ Mok SC, Chan WY, Wong KK, Cheung KK, Lau CC, Ng SW, Baldini A, Colitti CV, Rock CO, Berkowitz RS (June 1998). "DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer". Oncogene. 16 (18): 2381–7. doi:10.1038/sj.onc.1201769. PMID 9620555.
^ "Entrez Gene: DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)".
^ ^a ^b Zhou J, Scholes J, Hsieh JT (February 2003). "Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer". J. Biol. Chem. 278 (9): 6936–41. doi:10.1074/jbc.M210628200. PMID 12473651.
^ ^a ^b He J, Xu J, Xu XX, Hall RA (July 2003). "Cell cycle-dependent phosphorylation of Disabled-2 by cdc2". Oncogene. 22 (29): 4524–30. doi:10.1038/sj.onc.1206767. PMID 12881709.
^ Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
^ ^a ^b Hocevar BA, Mou F, Rennolds JL, Morris SM, Cooper JA, Howe PH (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. PMC 162138. PMID 12805222.
^ Oleinikov AV, Zhao J, Makker SP (May 2000). "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin". Biochem. J. 347 Pt 3 (3): 613–21. doi:10.1042/0264-6021:3470613. PMC 1220996. PMID 10769163.
^ Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. S2CID 25079713.
^ Inoue A, Sato O, Homma K, Ikebe M (March 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochem. Biophys. Res. Commun. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.
^ ^a ^b Hocevar BA, Smine A, Xu XX, Howe PH (June 2001). "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway". EMBO J. 20 (11): 2789–801. doi:10.1093/emboj/20.11.2789. PMC 125498. PMID 11387212.

추가 정보

Mok SC, Wong KK, Chan RK, Lau CC, Tsao SW, Knapp RC, Berkowitz RS (1994). "Molecular cloning of differentially expressed genes in human epithelial ovarian cancer". Gynecol. Oncol. 52 (2): 247–52. doi:10.1006/gyno.1994.1040. PMID 8314147.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Xu XX, Yi T, Tang B, Lambeth JD (1998). "Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2". Oncogene. 16 (12): 1561–9. doi:10.1038/sj.onc.1201678. PMID 9569023.
Fazili Z, Sun W, Mittelstaedt S, Cohen C, Xu XX (1999). "Disabled-2 inactivation is an early step in ovarian tumorigenicity". Oncogene. 18 (20): 3104–13. doi:10.1038/sj.onc.1202649. PMID 10340382.
Tseng CP, Ely BD, Pong RC, Wang Z, Zhou J, Hsieh JT (1999). "The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer". J. Biol. Chem. 274 (45): 31981–6. doi:10.1074/jbc.274.45.31981. PMID 10542228.
Oleinikov AV, Zhao J, Makker SP (2000). "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin". Biochem. J. 347 Pt 3 (3): 613–21. doi:10.1042/0264-6021:3470613. PMC 1220996. PMID 10769163.
Sheng Z, Sun W, Smith E, Cohen C, Sheng Z, Xu XX (2000). "Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells". Oncogene. 19 (42): 4847–54. doi:10.1038/sj.onc.1203853. PMID 11039902.
Sheng Z, He J, Tuppen JA, Sun W, Fazili Z, Smith ER, Dong FB, Xu XX (2000). "Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2)". Genomics. 70 (3): 381–6. doi:10.1006/geno.2000.6383. PMID 11161789.
Morris SM, Cooper JA (2001). "Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2". Traffic. 2 (2): 111–23. doi:10.1034/j.1600-0854.2001.020206.x. PMID 11247302. S2CID 33186168.
Zhou J, Hsieh JT (2001). "The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2". J. Biol. Chem. 276 (30): 27793–8. doi:10.1074/jbc.M102803200. PMID 11371563.
Hocevar BA, Smine A, Xu XX, Howe PH (2001). "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway". EMBO J. 20 (11): 2789–801. doi:10.1093/emboj/20.11.2789. PMC 125498. PMID 11387212.
Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
Inoue A, Sato O, Homma K, Ikebe M (2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochem. Biophys. Res. Commun. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.
Mishra SK, Keyel PA, Hawryluk MJ, Agostinelli NR, Watkins SC, Traub LM (2002). "Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor". EMBO J. 21 (18): 4915–26. doi:10.1093/emboj/cdf487. PMC 126284. PMID 12234931.
Morris SM, Tallquist MD, Rock CO, Cooper JA (2002). "Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport". EMBO J. 21 (7): 1555–64. doi:10.1093/emboj/21.7.1555. PMC 125955. PMID 11927540.
Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. S2CID 25079713.
Zhou J, Scholes J, Hsieh JT (2003). "Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer". J. Biol. Chem. 278 (9): 6936–41. doi:10.1074/jbc.M210628200. PMID 12473651.
Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH (2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2272–7. doi:10.1073/pnas.262791999. PMC 151330. PMID 12606711.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000153071 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000022150 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8660969-5] Albertsen HM, Smith SA, Melis R, Williams B, Holik P, Stevens J, White R (January 1997). "Sequence, genomic structure, and chromosomal assignment of human DOC-2". Genomics. 33 (2): 207–13. doi:10.1006/geno.1996.0185. PMID 8660969.

[pmid9620555-6] Mok SC, Chan WY, Wong KK, Cheung KK, Lau CC, Ng SW, Baldini A, Colitti CV, Rock CO, Berkowitz RS (June 1998). "DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer". Oncogene. 16 (18): 2381–7. doi:10.1038/sj.onc.1201769. PMID 9620555.

[entrez-7] "Entrez Gene: DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)".

[pmid12473651-8] Zhou J, Scholes J, Hsieh JT (February 2003). "Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer". J. Biol. Chem. 278 (9): 6936–41. doi:10.1074/jbc.M210628200. PMID 12473651.

[pmid12881709-9] He J, Xu J, Xu XX, Hall RA (July 2003). "Cell cycle-dependent phosphorylation of Disabled-2 by cdc2". Oncogene. 22 (29): 4524–30. doi:10.1038/sj.onc.1206767. PMID 12881709.

[pmid11812785-10] Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.

[pmid12805222-11] Hocevar BA, Mou F, Rennolds JL, Morris SM, Cooper JA, Howe PH (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. PMC 162138. PMID 12805222.

[pmid10769163-12] Oleinikov AV, Zhao J, Makker SP (May 2000). "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin". Biochem. J. 347 Pt 3 (3): 613–21. doi:10.1042/0264-6021:3470613. PMC 1220996. PMID 10769163.

[pmid11967127-13] Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. S2CID 25079713.

[pmid11906161-14] Inoue A, Sato O, Homma K, Ikebe M (March 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochem. Biophys. Res. Commun. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.

[pmid11387212-15] Hocevar BA, Smine A, Xu XX, Howe PH (June 2001). "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway". EMBO J. 20 (11): 2789–801. doi:10.1093/emboj/20.11.2789. PMC 125498. PMID 11387212.

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Search

DAB2

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보