호모 사피엔스 종의 단백질 코드 유전자
머스큘린 은 사람 에게서 [5] [6] [7] MSC 유전자에 의해 암호화되는 단백질 이다.
이 유전자에 의해 코드된 단백질은 E-box 요소를 시험관 E2A 호모디머 또는 헤테로디머로 결합할 수 있는 전사 억제제 이다. 또한 암호화된 단백질은 체내 단백질 헤테로디미터 를 형성한다. 이 단백질은 포유류 세포에서 E2A 단백질인 E47 의 활성화 능력 을 억제할 수 있다. 이 유전자는 B세포 수용체 신호 전달 [7]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000178860 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025930 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, van Dongen JJ, de Smit O, Murre C (Jun 1998). "Characterization of ABF-1, a Novel Basic Helix-Loop-Helix Transcription Factor Expressed in Activated B Lymphocytes" . Mol Cell Biol . 18 (6): 3130–9. doi :10.1128/mcb.18.6.3130 . PMC 108895 PMID 9584154 . ^ Robb L, Brodnicki T, Copeland NG, Gilbert DJ, Jenkins NA, Harvey RP (May 1999). "Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1". Genomics . 57 (2): 318–9. doi :10.1006/geno.1999.5764 . PMID 10198176 . ^ a b "Entrez Gene: MSC musculin (activated B-cell factor-1)" . 추가 정보 Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Robb L, Hartley L, Wang CC, et al. (1998). "musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle" . Mech. Dev . 76 (1–2): 197–201. doi :10.1016/S0925-4773(98)00122-1 PMID 9767165 . S2CID 780834 . Wong J, Funes-Duran M, Ahlberg J, et al. (2001). "Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id-2". DNA Cell Biol . 20 (8): 465–71. doi :10.1089/104454901316976091 . PMID 11560778 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Knight JC, Keating BJ, Kwiatkowski DP (2004). "Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1" . Nat. Genet . 36 (4): 394–9. doi :10.1038/ng1331 PMID 15052269 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 .
