KLK10

KLK10
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1SPJ
식별자
에일리어스	KLK10, NES1, PRSL1, 칼리크레인관련펩티드가수분해효소10
외부 ID	OMIM: 602673 MGI: 1916790 HomoloGene: 26428 GeneCard: KLK10
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	51,020,175 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	43,434,834 bp
RNA발현패턴
	상단 표시 위치:
	잇몸; ; 인간의 음경; ; 구강; ; 외음부; ; 식도 상피; ; 설체; ; 복부 피부; ; 자궁경부상피; ; 우측 자궁관; ; 질;
	상단 표시 위치:
	입술; ; 식도; ; 등살; ; 복부 피부; ; 자궁경부; ; 직장; ; 배; ; 혀; ; 대동맥; ; 기관;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	펩티드가수분해효소활성; 세린형펩티드가수분해효소활성; 가수분해효소활성; 세린형 엔도펩티드가수분해효소활성;
셀룰러 컴포넌트	세포외 영역; 분비 과립;
생물학적 과정	세포 주기; 단백질 분해;
	출처:아미고 / QuickGO
맞춤법
	5655
	69540
	ENSG00000129451
	ENSMUSG000030693
	O43240
	Q99M20
	NM_001077500; NM_002776; NM_145888
	NM_133712
	NP_001070968; NP_002767; NP_665895
	NP_598473
	위키데이터
인간 보기/편집	마우스 표시/편집

Kallikrein-10은 KLK10 유전자에 ^[5]^[6]^[7]^[8]^[9]의해 인간에게 암호화되는 단백질이다.

칼리크레인(Kallikreins)은 다양한 생리 기능을 가진 세린 단백질 분해 효소의 하위 그룹이다.늘어나는 증거는 많은 칼리크레인들이 발암에 관여하고 있고 일부는 새로운 암과 다른 질병 바이오마커로 잠재되어 있다는 것을 암시한다.이 유전자는 19번 염색체의 클러스터에 위치한 15개의 칼리크레인 아족 중 하나이다.암호화된 단백질은 분비되며 유방암과 전립선암에서 종양 발생을 억제하는 역할을 할 수 있다.이 유전자의 대체 스플라이싱은 동일한 단백질을 ^[9]코드하는 여러 전사 변이체를 낳는다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000129451 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000030693 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu XL, Wazer DE, Watanabe K, Band V (Sep 1996). "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression". Cancer Res. 56 (14): 3371–9. PMID 8764136.
^ Polikoff D, Kuo WL, Cochran JF, Wernick M, Kowbel D, Myambo K, Collins CC (Apr 1998). "Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping". Cytogenet Cell Genet. 79 (1–2): 147–8. doi:10.1159/000134705. PMID 9533035.
^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
^ ^a ^b "Entrez Gene: KLK10 kallikrein-related peptidase 10".

추가 정보

Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis". Trends Endocrinol. Metab. 11 (2): 54–60. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891. S2CID 25806934.
Zhang Y, Bhat I, Zeng M, et al. (2006). "Human kallikrein 10, a predictive marker for breast cancer". Biol. Chem. 387 (6): 715–21. doi:10.1515/BC.2006.090. PMID 16800732. S2CID 1962156.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Luo L, Herbrick JA, Scherer SW, et al. (1998). "Structural characterization and mapping of the normal epithelial cell-specific 1 gene". Biochem. Biophys. Res. Commun. 247 (3): 580–6. doi:10.1006/bbrc.1998.8793. PMID 9647736.
Goyal J, Smith KM, Cowan JM, et al. (1998). "The role for NES1 serine protease as a novel tumor suppressor". Cancer Res. 58 (21): 4782–6. PMID 9809976.
Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–406. doi:10.1074/jbc.M004525200. PMID 10969073.
Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
Dhar S, Bhargava R, Yunes M, et al. (2002). "Analysis of normal epithelial cell specific-1 (NES1)/kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer". Clin. Cancer Res. 7 (11): 3393–8. PMID 11705853.
Bharaj BB, Luo LY, Jung K, et al. (2002). "Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers". Prostate. 51 (1): 35–41. doi:10.1002/pros.10076. PMID 11920956. S2CID 27003835.
Luo LY, Diamandis EP, Look MP, et al. (2002). "Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance". Br. J. Cancer. 86 (11): 1790–6. doi:10.1038/sj.bjc.6600323. PMC 2375391. PMID 12087468.
Petraki CD, Karavana VN, Luo LY, Diamandis EP (2002). "Human kallikrein 10 expression in normal tissues by immunohistochemistry". J. Histochem. Cytochem. 50 (9): 1247–61. doi:10.1177/002215540205000912. PMID 12185203.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Petraki CD, Gregorakis AK, Papanastasiou PA, et al. (2004). "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues". Prostate Cancer Prostatic Dis. 6 (3): 223–7. doi:10.1038/sj.pcan.4500674. PMID 12970725.
Sauter ER, Lininger J, Magklara A, et al. (2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk". Int. J. Cancer. 108 (4): 588–91. doi:10.1002/ijc.11607. PMID 14696124. S2CID 29116787.
Diamandis EP, Scorilas A, Kishi T, et al. (2004). "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia". Clin. Biochem. 37 (3): 230–7. doi:10.1016/j.clinbiochem.2003.11.012. PMID 14972646.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

외부 링크

펩티드가수분해효소 및 그 억제제에 대한 MEROPS 온라인 데이터베이스: S01.246

인간 염색체 19번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000129451 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000030693 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8764136-5] Liu XL, Wazer DE, Watanabe K, Band V (Sep 1996). "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression". Cancer Res. 56 (14): 3371–9. PMID 8764136.

[pmid9533035-6] Polikoff D, Kuo WL, Cochran JF, Wernick M, Kowbel D, Myambo K, Collins CC (Apr 1998). "Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping". Cytogenet Cell Genet. 79 (1–2): 147–8. doi:10.1159/000134705. PMID 9533035.

[pmid16800724-7] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-8] Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[entrez-9] "Entrez Gene: KLK10 kallikrein-related peptidase 10".

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KLK10

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