FERM, RoGEF 및 플렉스트린 도메인 함유 단백질 2는 FARP2 [5] [6] [7] 단백질 이다.
모델 유기체 모델 유기체는 FARP2 기능의 연구에 사용되어 왔다.Farp2 라고tm1a(KOMP)Wtsi [12] [13] 조건부 녹아웃 마우스 라인이 International Knockout Mouse Consortium 프로그램의 일부로 생성되었습니다.이것은 질병 동물 모델을 생성하여 관심 있는 [14] [15] [16]
수컷과 암컷은 표준화된 표현형 검사를 통해 [10] [17] 돌연변이 생쥐에 대해 24개의 검사가 수행되었고 2개의 유의한 이상이 [10] 호모 접합 돌연변이 동물은 대뇌피질이 두꺼워지고 [10]
상호 작용 FARP2는 PDZK1 과 [18] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000006607 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000034066 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 5 (5): 277–86. doi :10.1093/dnares/5.5.277 PMID 9872452 . ^ Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M (Oct 2002). "A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling" . The Journal of Neuroscience . 22 (19): 8504–13. doi :10.1523/JNEUROSCI.22-19-08504.2002 . PMC 6757789 PMID 12351724 . ^ "Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2" .^ "Salmonella infection data for Farp2" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Farp2" . Wellcome Trust Sanger Institute.^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Wellcome Trust Sanger Institute의 마우스 리소스 포털.^ "International Knockout Mouse Consortium" .^ "Mouse Genome Informatics" .^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (Jun 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biology . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 . ^ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells" . Kidney International . 64 (5): 1733–45. doi :10.1046/j.1523-1755.2003.00266.x PMID 14531806 . 추가 정보 Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology . 14 (16): 1436–50. doi :10.1016/j.cub.2004.07.051 . PMID 15324660 . S2CID 2371325 . Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells" . Kidney International . 64 (5): 1733–45. doi :10.1046/j.1523-1755.2003.00266.x PMID 14531806 . Miyamoto Y, Yamauchi J, Itoh H (Aug 2003). "Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK" . The Journal of Biological Chemistry . 278 (32): 29890–900. doi :10.1074/jbc.M301559200 PMID 12771149 . Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence" . Genome Research . 8 (11): 1097–108. doi :10.1101/gr.8.11.1097 PMID 9847074 .
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