DExH 상자 헬리케이스 29(DHX29 )는 인간에서 DHX29 [5] kDa 단백질이다.
기능. 이 유전자는 단백질의 DEAH (Asp-Glu-Ala-His) 서브패밀리의 멤버, RNA 헬리케이스 의 DEAD (Asp-Glu-Ala-Asp) 박스패밀리의 일부를 코드한다. 부호화된 단백질은 번역 개시 에 기능하며, 특히 개시 코돈 [6] 이 단백질은 또한 바이러스 유도 세포핵산을 [7] 이 유전자의 녹다운은 단백질 번역의 감소 와 암세포의 [8]
상호 작용 DHX29는 진핵생물 소형 리보솜 서브유닛(40S) 및 eIF3 과 [9] [10] [11] [12] 것 으로 나타났다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000067248 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000042426 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: DExH-box helicase 29" .^ Pisareva VP, Pisarev AV, Komar AA, Hellen CU, Pestova TV (December 2008). "Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29" . Cell . 135 (7): 1237–50. doi :10.1016/j.cell.2008.10.037 . PMC 2948571 PMID 19109895 . ^ Sugimoto N, Mitoma H, Kim T, Hanabuchi S, Liu YJ (May 2014). "Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system" . Proceedings of the National Academy of Sciences of the United States of America . 111 (21): 7747–52. Bibcode :2014PNAS..111.7747S . doi :10.1073/pnas.1400139111 PMC 4040624 PMID 24821782 . ^ Parsyan A, Shahbazian D, Martineau Y, Petroulakis E, Alain T, Larsson O, Mathonnet G, Tettweiler G, Hellen CU, Pestova TV, Svitkin YV, Sonenberg N (December 2009). "The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis" . Proceedings of the National Academy of Sciences of the United States of America . 106 (52): 22217–22. Bibcode :2009PNAS..10622217P . doi :10.1073/pnas.0909773106 PMC 2799747 PMID 20018725 . ^ Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Hellen CU, Pestova TV, Frank J (May 2013). "Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29" . Cell . 153 (5): 1108–19. doi :10.1016/j.cell.2013.04.036 . PMC 3730827 PMID 23706745 . ^ Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Pestova TV, Hellen CU, Frank J (November 2013). "Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit" . Nature . 503 (7477): 539–43. Bibcode :2013Natur.503..539H . doi :10.1038/nature12658 . PMC 4106463 PMID 24185006 . ^ Pisareva VP, Pisarev AV (December 2016). "DHX29 and eIF3 cooperate in ribosomal scanning on structured mRNAs during translation initiation" . RNA . 22 (12): 1859–1870. doi :10.1261/rna.057851.116 . PMC 5113206 PMID 27733651 . ^ des Georges A, Dhote V, Kuhn L, Hellen CU, Pestova TV, Frank J, Hashem Y (September 2015). "Structure of mammalian eIF3 in the context of the 43S preinitiation complex" . Nature . 525 (7570): 491–5. Bibcode :2015Natur.525..491D . doi :10.1038/nature14891 . PMC 4719162 PMID 26344199 .
추가 정보 Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (September 2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression" . PLOS ONE . 5 (9): e12862. Bibcode :2010PLoSO...512862H . doi :10.1371/journal.pone.0012862 PMC 2943476 PMID 20877624 . Dhote V, Sweeney TR, Kim N, Hellen CU, Pestova TV (November 2012). "Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs" . Proceedings of the National Academy of Sciences of the United States of America . 109 (46): E3150-9. doi :10.1073/pnas.1208014109 PMC 3503174 PMID 23047696 . Pisareva VP, Pisarev AV (May 2016). "DHX29 reduces leaky scanning through an upstream AUG codon regardless of its nucleotide context" . Nucleic Acids Research . 44 (9): 4252–65. doi :10.1093/nar/gkw240 . PMC 4872109 PMID 27067542 . 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
