DEC1

델렉1
식별자
에일리어스	DELC1, CTS9, 식도암 1, DEC1에서 삭제
외부 ID	OMIM: 604767 GeneCard: DELC1
유전자 위치(인간)
크르.	9번 염색체(인간)
끝.	115,402,644 bp
RNA발현패턴
	없음
	추가 참조 표현식 데이터
맞춤법
	50514
	없음
	ENSG00000173077
	없음
	Q9P2X7
	없음
	NM_017418
	없음
	NP_059114
	없음
	위키데이터
인간 보기/편집

식도암 1에서 삭제된 단백질은 ^[3]^[4]^[5]DEC1 유전자에 의해 인간의 체내에서 코드되는 단백질이다.

기능.

이 유전자의 기능은 알려지지 않았다.이 유전자는 식도 편평상피암에서 흔히 제거되는 영역에 위치한다.림프절 전이와 관련된 이들 암종에서 유전자 발현이 감소하거나 없어 식도 편평상피암 ^[5]후보 종양 억제 유전자이다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000173077 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y (May 1996). "Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q". Cancer Res. 56 (7): 1629–34. PMID 8603412.
^ Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y (Feb 2000). "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32". Genes Chromosomes Cancer. 27 (2): 169–76. doi:10.1002/(SICI)1098-2264(200002)27:2<169::AID-GCC8>3.0.CO;2-M. PMID 10612805.
^ ^a ^b "Entrez Gene: DEC1 deleted in esophageal cancer 1".

추가 정보

Qian Y, Zhang J, Yan B, Chen X (2008). "DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence". J. Biol. Chem. 283 (5): 2896–905. doi:10.1074/jbc.M708624200. PMC 4118587. PMID 18025081.
Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML (2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma". Int. J. Cancer. 122 (3): 587–94. doi:10.1002/ijc.23144. PMID 17943723.
Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B (2006). "The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter". Oncogene. 25 (23): 3296–306. doi:10.1038/sj.onc.1209363. PMC 4114758. PMID 16462771.
Preusser M, Birner P, Ambros IM, Ambros PF, Budka H, Harris AL, Hainfellner JA (2006). "DEC1 expression in 1p-aberrant oligodendroglial neoplasms". Histol. Histopathol. 20 (4): 1173–7. PMID 16136500.
Yang L, Leung AC, Ko JM, Lo PH, Tang JC, Srivastava G, Oshimura M, Stanbridge EJ, Daigo Y, Nakamura Y, Tang CM, Lau KW, Law S, Lung ML (2005). "Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma". Oncogene. 24 (4): 697–705. doi:10.1038/sj.onc.1208179. PMID 15580306.
Wong VC, Ko JM, Qi RZ, Li PJ, Wang LD, Li JL, Chan YP, Chan KW, Stanbridge EJ, Lung ML (Mar 1, 2011). "Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis". British Journal of Cancer. 104 (5): 841–9. doi:10.1038/bjc.2011.25. PMC 3048215. PMID 21326238.
Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML (Feb 1, 2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma". International Journal of Cancer. 122 (3): 587–94. doi:10.1002/ijc.23144. PMID 17943723.

인간 염색체 9번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000173077 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8603412-3] Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y (May 1996). "Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q". Cancer Res. 56 (7): 1629–34. PMID 8603412.

[pmid10612805-4] Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y (Feb 2000). "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32". Genes Chromosomes Cancer. 27 (2): 169–76. doi:10.1002/(SICI)1098-2264(200002)27:2<169::AID-GCC8>3.0.CO;2-M. PMID 10612805.

[entrez-5] "Entrez Gene: DEC1 deleted in esophageal cancer 1".

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DEC1

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