호모 사피엔스 종의 단백질 코드 유전자
자매염색체 응집단백질 DCC1 은 인간 에서 DSCC1 유전자에 [5] [6] 단백질 이다.
모델 유기체 모델 유기체는 DSCC1 기능의 연구에 사용되어 왔다.Wellcome Trust Sanger Institute에서는 International Knockout Mouse Consortium 프로그램 의 일환으로 Dscc1 이라는tm1a(KOMP)Wtsi [12] [13] 조건부 녹아웃 마우스 라인이 생성되어 관심 있는 [14] [15] [16]
수컷과 암컷은 표준화된 표현형 검사를 통해 [10] [17] 돌연변이 생쥐에 대해 24개의 검사가 수행되었고 4개의 유의한 이상이 [10] 임신 중 동종 돌연변이 배아는 거의 확인되지 않았으며 일부는 부종 을 보여 젖 을 뗄 때까지 예상보다 적게 살아남았다. 살아남은 사람들은 소핵 검사 에서 염색체 불안정성을 증가시켰고 방사선 촬영에 [10]
상호 작용 DCC1은 CHTF18 과 [18] [19] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000136982 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022422 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment" . The Journal of Biological Chemistry . 278 (32): 30051–6. doi :10.1074/jbc.M211591200 PMID 12766176 . ^ "Entrez Gene: DCC1 defective in sister chromatid cohesion homolog 1 (S. cerevisiae)" .^ "Radiography data for Dscc1" . Wellcome Trust Sanger Institute.^ "Salmonella infection data for Dscc1" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Dscc1" . 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Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (Jun 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biology . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 . ^ Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment" . The Journal of Biological Chemistry . 278 (32): 30051–6. doi :10.1074/jbc.M211591200 PMID 12766176 . ^ Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA" . Proceedings of the National Academy of Sciences of the United States of America . 100 (18): 10237–42. doi :10.1073/pnas.1434308100 PMC 193545 PMID 12930902 . 추가 정보 Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein" . The Journal of Biological Chemistry . 277 (43): 40362–7. doi :10.1074/jbc.M206194200 PMID 12171929 . Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA" . 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