사이클린 T1

CCNT1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2PK2, 3BLH, 3BLQ, 3BLR, 3LQ5, 3MI9, 3MIA, 3MY1, 3TN8, 3TNH, 3TNI, 4BCF, 4BCG, 4BCH, 4BCCH, 4BCI, 4JEC, 4BLQ, 3MY8
식별자
에일리어스	CCNT1, CCNT, CYCT1, HIVE1, 사이클린 T1
외부 ID	OMIM: 143055 MGI: 1328363 HomoloGene: 947 GeneCard: CCNT1
유전자 위치(인간)
크르.	12번 염색체(인간)
끝.	48,716,998 bp
유전자 위치(마우스)
크르.	15번 염색체(쥐)
끝.	98,468,804 bp
RNA발현패턴
	상단 표시 위치:
	정자; ; 혀 윗면; ; 신장수질; ; 유문; ; 유즙관; ; 부고환 카푸트; ; 니플; ; 심막; ; 폐하엽; ; 부고환 말뭉치;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; snRNA 결합; 크로마틴 결합; 7SK snRNA 바인딩; 사이클린 의존성 단백질 세린/트레오닌인산화효소조절제활성; GO:0001948 단백질 결합; RNA중합효소결합; 전사 인자 결합; 단백질세린/트레오닌인산화효소활성; 단백질인산화효소결합; GO:0016534 사이클린 의존성 단백질 세린/트레오닌 키나아제 활성;
셀룰러 컴포넌트	핵소체; 핵소체; 사이클린/CDK양성전사인자복합체; 핵; 사이클린 의존성 단백질인산화효소홀로엔자임복합체;
생물학적 과정	사이클린 의존성 단백질 세린/트레오닌인산화효소 활성 조절; mRNA 폴리아데닐화 음성조절; 전사조절, DNA템플릿화; RNA중합효소II 프로모터로부터의 전사 신장; RNA중합효소II에 의한 전사; 세포 분열; 단백질인산화; RNA중합효소IIC말단도메인의인산화양성조절; 사이클린 의존성 단백질 세린/트레오닌인산화효소 활성의 양성 조절; 바이러스 전사의 양성 조절; 세포 주기; RNA중합효소II에 의한 전사의 양성 조절; GO:0022415 바이러스 처리; 전사, DNA 템플릿; RNA중합효소II에 의한 snRNA 전사; RNA중합효소II에 의한 전사조절; DNA-템플릿 전사의 양성 조절, 신장;
	출처:아미고 / QuickGO
맞춤법
	904
	12455
	ENSG00000129315
	ENSMUSG000011960
	O60563
	Q9QWV9
	NM_001240; NM_001277842
	NM_009833; NM_001368702
	NP_001231; NP_001264771
	NP_033963; NP_001355631
	위키데이터
인간 보기/편집	마우스 표시/편집

Cyclin-T1은 CCNT1 ^[5]^[6]유전자에 의해 인간에게 암호화되는 단백질이다.

기능.

이 유전자에 의해 암호화된 단백질은 고도로 보존된 사이클린 계열에 속하며, 그 구성원들은 세포 주기 동안 단백질 풍부함의 극적인 주기성으로 특징지어진다.사이클린은 CDK 키나아제 조절제 역할을 한다.서로 다른 사이클린은 각 유사분열 이벤트의 시간적 조정에 기여하는 뚜렷한 발현 및 분해 패턴을 나타낸다.이 사이클린은 CDK9 키나제와 밀접하게 연관되어 있으며, 전사 신장 인자 p-TEFb의 주요 서브유닛으로 확인되었다.이 사이클린과 신장 인자를 포함하는 키나제 복합체는 인간 면역 결핍 바이러스 타입 1(HIV-1) Tat 단백질과 상호작용할 수 있고, 보조 인자로 작용하며, 바이러스 전사의 완전한 활성화에 필요하고 충분한 것으로 나타났다.이 사이클린과 그 키나제 파트너는 또한 가장 큰 RNA 중합효소 II 서브유닛의 ^[7]카르복시 말단 도메인(CTD)의 인산화 및 조절에 관여하는 것으로 밝혀졌다.

상호 작용

Cyclin T1은 다음과 상호작용하는 것으로 나타났습니다.

아릴탄화수소수용체^[8]
CDK9^[6]^[9]^[10]^[11]^[12]^[13]^[14]^[15]^[16]
그라눌린^[10]
HEXIM1^[9]
마이크^[17]
NUFIP1^[11]
전골수성 백혈병 단백질^[18]

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000129315 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000011960 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wei P, Garber ME, Fang SM, Fischer WH, Jones KA (March 1998). "A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA". Cell. 92 (4): 451–62. doi:10.1016/S0092-8674(00)80939-3. PMID 9491887. S2CID 16395032.
^ ^a ^b Peng J, Zhu Y, Milton JT, Price DH (April 1998). "Identification of multiple cyclin subunits of human P-TEFb". Genes Dev. 12 (5): 755–62. doi:10.1101/gad.12.5.755. PMC 316581. PMID 9499409.
^ "Entrez Gene: CCNT1 cyclin T1".
^ Tian Y, Ke S, Chen M, Sheng T (November 2003). "Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter". J. Biol. Chem. 278 (45): 44041–8. doi:10.1074/jbc.M306443200. PMID 12917420.
^ ^a ^b Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (July 2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner". Mol. Cell. Biol. 23 (14): 4859–69. doi:10.1128/mcb.23.14.4859-4869.2003. PMC 162212. PMID 12832472.
^ ^a ^b Hoque M, Young TM, Lee CG, Serrero G, Mathews MB, Pe'ery T (March 2003). "The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription". Mol. Cell. Biol. 23 (5): 1688–702. doi:10.1128/mcb.23.5.1688-1702.2003. PMC 151712. PMID 12588988.
^ ^a ^b Cabart P, Chew HK, Murphy S (July 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene. 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825.
^ Young TM, Wang Q, Pe'ery T, Mathews MB (September 2003). "The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription". Mol. Cell. Biol. 23 (18): 6373–84. doi:10.1128/mcb.23.18.6373-6384.2003. PMC 193714. PMID 12944466.
^ Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, Nakayama Ki K, Benkirane M (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.
^ De Falco G, Bagella L, Claudio PP, De Luca A, Fu Y, Calabretta B, Sala A, Giordano A (January 2000). "Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation". Oncogene. 19 (3): 373–9. doi:10.1038/sj.onc.1203305. PMID 10656684.
^ Fu TJ, Peng J, Lee G, Price DH, Flores O (December 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". J. Biol. Chem. 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912.
^ Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (September 2000). "CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA". Mol. Cell. Biol. 20 (18): 6958–69. doi:10.1128/mcb.20.18.6958-6969.2000. PMC 88771. PMID 10958691.
^ Kanazawa S, Soucek L, Evan G, Okamoto T, Peterlin BM (August 2003). "c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis". Oncogene. 22 (36): 5707–11. doi:10.1038/sj.onc.1206800. PMID 12944920.
^ Marcello A, Ferrari A, Pellegrini V, Pegoraro G, Lusic M, Beltram F, Giacca M (May 2003). "Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein". EMBO J. 22 (9): 2156–66. doi:10.1093/emboj/cdg205. PMC 156077. PMID 12727882.

추가 정보

Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447-9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A (1999). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359.
Cunningham AL, Li S, Juarez J, Lynch G, Alali M, Naif H (2000). "The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes". J. Leukoc. Biol. 68 (3): 311–7. PMID 10985245.
Marcello A, Zoppé M, Giacca M (2001). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. doi:10.1080/152165401753544241. PMID 11547919. S2CID 10931640.
Huigen MC, Kamp W, Nottet HS (2004). "Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection". Eur. J. Clin. Invest. 34 (1): 57–66. doi:10.1111/j.1365-2362.2004.01282.x. PMID 14984439. S2CID 29713968.
Rice AP, Herrmann CH (2003). "Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages". Curr. HIV Res. 1 (4): 395–404. doi:10.2174/1570162033485159. PMID 15049426.
Minghetti L, Visentin S, Patrizio M, Franchini L, Ajmone-Cat MA, Levi G (2004). "Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions". Neurochem. Res. 29 (5): 965–78. doi:10.1023/B:NERE.0000021241.90133.89. PMID 15139295. S2CID 25323034.
Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
Liou LY, Herrmann CH, Rice AP (2004). "HIV-1 infection and regulation of Tat function in macrophages". Int. J. Biochem. Cell Biol. 36 (9): 1767–75. doi:10.1016/j.biocel.2004.02.018. PMID 15183343.
Pugliese A, Vidotto V, Beltramo T, Petrini S, Torre D (2005). "A review of HIV-1 Tat protein biological effects". Cell Biochem. Funct. 23 (4): 223–7. doi:10.1002/cbf.1147. PMID 15473004. S2CID 8408278.
Bannwarth S, Gatignol A (2005). "HIV-1 TAR RNA: the target of molecular interactions between the virus and its host". Curr. HIV Res. 3 (1): 61–71. doi:10.2174/1570162052772924. PMID 15638724.
Gibellini D, Vitone F, Schiavone P, Re MC (2005). "HIV-1 tat protein and cell proliferation and survival: a brief review". New Microbiol. 28 (2): 95–109. PMID 16035254.
Peruzzi F (2006). "The multiple functions of HIV-1 Tat: proliferation versus apoptosis" (PDF). Front. Biosci. 11: 708–717. doi:10.2741/1829. PMID 16146763. S2CID 12438136. Archived from the original (PDF) on 2019-02-24.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000129315 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000011960 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9491887-5] Wei P, Garber ME, Fang SM, Fischer WH, Jones KA (March 1998). "A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA". Cell. 92 (4): 451–62. doi:10.1016/S0092-8674(00)80939-3. PMID 9491887. S2CID 16395032.

[pmid9499409-6] Peng J, Zhu Y, Milton JT, Price DH (April 1998). "Identification of multiple cyclin subunits of human P-TEFb". Genes Dev. 12 (5): 755–62. doi:10.1101/gad.12.5.755. PMC 316581. PMID 9499409.

[7] "Entrez Gene: CCNT1 cyclin T1".

[pmid12917420-8] Tian Y, Ke S, Chen M, Sheng T (November 2003). "Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter". J. Biol. Chem. 278 (45): 44041–8. doi:10.1074/jbc.M306443200. PMID 12917420.

[pmid12832472-9] Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (July 2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner". Mol. Cell. Biol. 23 (14): 4859–69. doi:10.1128/mcb.23.14.4859-4869.2003. PMC 162212. PMID 12832472.

[pmid12588988-10] Hoque M, Young TM, Lee CG, Serrero G, Mathews MB, Pe'ery T (March 2003). "The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription". Mol. Cell. Biol. 23 (5): 1688–702. doi:10.1128/mcb.23.5.1688-1702.2003. PMC 151712. PMID 12588988.

[pmid15107825-11] Cabart P, Chew HK, Murphy S (July 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene. 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825.

[pmid12944466-12] Young TM, Wang Q, Pe'ery T, Mathews MB (September 2003). "The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription". Mol. Cell. Biol. 23 (18): 6373–84. doi:10.1128/mcb.23.18.6373-6384.2003. PMC 193714. PMID 12944466.

[pmid11689688-13] Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, Nakayama Ki K, Benkirane M (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.

[pmid10656684-14] De Falco G, Bagella L, Claudio PP, De Luca A, Fu Y, Calabretta B, Sala A, Giordano A (January 2000). "Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation". Oncogene. 19 (3): 373–9. doi:10.1038/sj.onc.1203305. PMID 10656684.

[pmid10574912-15] Fu TJ, Peng J, Lee G, Price DH, Flores O (December 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". J. Biol. Chem. 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912.

[pmid10958691-16] Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (September 2000). "CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA". Mol. Cell. Biol. 20 (18): 6958–69. doi:10.1128/mcb.20.18.6958-6969.2000. PMC 88771. PMID 10958691.

[pmid12944920-17] Kanazawa S, Soucek L, Evan G, Okamoto T, Peterlin BM (August 2003). "c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis". Oncogene. 22 (36): 5707–11. doi:10.1038/sj.onc.1206800. PMID 12944920.

[pmid12727882-18] Marcello A, Ferrari A, Pellegrini V, Pegoraro G, Lusic M, Beltram F, Giacca M (May 2003). "Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein". EMBO J. 22 (9): 2156–66. doi:10.1093/emboj/cdg205. PMC 156077. PMID 12727882.

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사이클린 T1

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보