CSTF2

CSTF2
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1P1T, 2J8P
식별자
별칭	CSTF2, CstF-64, 구획 자극 계수 하위 단위 2
외부 ID	OMIM: 300907 MGI: 1343054 HomoloGene: 80171 GeneCard: CSTF2
유전자 위치(인간)
쳇.	X염색체(인간)
끝	100,841,192 bp
유전자 위치(마우스)
쳇.	X염색체(쥐)
끝	132,987,568 bp
RNA 표현 패턴
	표현된 상단
	흉선; ; 식도; ; 추골결막; ; 구강; ; 난소의; ; 고환;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	핵산 결합; GO:0001948 단백질 결합; mRNA 바인딩; RNA 결합;
셀룰러 컴포넌트	mRNA 분할 및 폴리아데닐화 특화 계수 복합체; 갈라진 몸체; 핵종의; 핵의; 핵체;
생물학적 과정	mRNA 스플라이싱, 스플라이소솜을 통해; RNA 중합효소 II 전사의 종료; mRNA처리; mRNA 3' 엔드 처리; 폴리아데닐화에 필요한 mRNA 이전 분할; tRNA 스플리싱, 내핵분열 및 결찰에 의한 스플리싱; mRNA 폴리아데닐화;
	출처:아미고 / 퀵고
직교체
	1478
	108062
	ENSG00000101811
	ENSMUSG00000031256
	P33240
	Q8BIQ5
	NM_001306206; NM_001306209; NM_001325
	NM_001290398; NM_001290399; NM_133196; NM_001359053; NM_001359054
	NP_001293135; NP_001293138; NP_001316; NP_001293135.1
	NP_001277327; NP_001277328; NP_573459; NP_001345982; NP_001345983
	위키다타
인간 보기/편집	마우스 보기/편집

클라베지 자극 인자 64 kDa 서브유닛은 인간에서 CSTF2 유전자에 의해 인코딩되는 단백질이다.^[5]^[6]

이 유전자는 핵 단백질을 RRM(RNA 인식 모티브) 영역으로 인코딩한다.단백질은 전 mRNA의 3 끝단 갈라짐과 폴리아데닐화에 관여하는 갈라짐 자극 인자(CSTF) 복합체의 일원이다.특히, 이 단백질은 mRNA의 3'불분산 영역 내에 GU가 풍부한 원소를 결합한다.^[6]

상호작용

CSTF2는 CSTF3, ^[7]SUB1, ^[8]SOMPK,^[7] BARD1^[9]^[10], BRCA1과 상호작용하는 것으로 나타났다.^[9]^[10]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000101811 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000031256 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takagaki Y, MacDonald CC, Shenk T, Manley JL (March 1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc Natl Acad Sci U S A. 89 (4): 1403–7. Bibcode:1992PNAS...89.1403T. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396.
^ ^a ^b "Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa".
^ ^a ^b Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729.
^ Calvo, O; Manley J L (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell. 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. ISSN 1097-2765. PMID 11389848.
^ ^a ^b Kleiman, F E; Manley J L (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. ISSN 0092-8674. PMID 11257228.
^ ^a ^b Kleiman, F E; Manley J L (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523.

외부 링크

UCSC 게놈 브라우저의 인간 CSTF2 게놈 위치 및 CSTF2 유전자 세부 정보 페이지.

추가 읽기

Takagaki Y, Manley JL (1992). "A human polyadenylation factor is a G protein beta-subunit homologue". J. Biol. Chem. 267 (33): 23471–4. doi:10.1016/S0021-9258(18)35861-7. PMID 1358884.
Murthy KG, Manley JL (1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
Takagaki Y, Manley JL (1994). "A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein". Nature. 372 (6505): 471–4. Bibcode:1994Natur.372..471T. doi:10.1038/372471a0. PMID 7984242. S2CID 4329672.
Rüegsegger U, Beyer K, Keller W (1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". J. Biol. Chem. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.
Schul W, Groenhout B, Koberna K, et al. (1996). "The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA". EMBO J. 15 (11): 2883–92. doi:10.1002/j.1460-2075.1996.tb00649.x. PMC 450226. PMID 8654386.
Takagaki Y, Seipelt RL, Peterson ML, Manley JL (1997). "The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation". Cell. 87 (5): 941–52. doi:10.1016/S0092-8674(00)82000-0. PMID 8945520.
Takagaki Y, Manley JL (1997). "RNA recognition by the human polyadenylation factor CstF". Mol. Cell. Biol. 17 (7): 3907–14. doi:10.1128/MCB.17.7.3907. PMC 232243. PMID 9199325.
Martincic K, Campbell R, Edwalds-Gilbert G, et al. (1998). "Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11095–100. Bibcode:1998PNAS...9511095M. doi:10.1073/pnas.95.19.11095. PMC 21601. PMID 9736695.
Takagaki Y, Manley JL (1999). "Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation". Mol. Cell. 2 (6): 761–71. doi:10.1016/S1097-2765(00)80291-9. PMID 9885564.
Kleiman FE, Manley JL (1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. PMID 10477523.
Takagaki Y, Manley JL (2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. PMC 85326. PMID 10669729.
Dass B, McMahon KW, Jenkins NA, et al. (2001). "The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice". J. Biol. Chem. 276 (11): 8044–50. doi:10.1074/jbc.M009091200. PMID 11113135.
Kleiman FE, Manley JL (2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. PMID 11257228.
Calvo O, Manley JL (2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell. 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. PMID 11389848.
Bléoo S, Sun X, Hendzel MJ, et al. (2002). "Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA". Mol. Biol. Cell. 12 (10): 3046–59. doi:10.1091/mbc.12.10.3046. PMC 60154. PMID 11598190.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pérez Cañadillas JM, Varani G (2003). "Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein". EMBO J. 22 (11): 2821–30. doi:10.1093/emboj/cdg259. PMC 156756. PMID 12773396.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Xing H, Mayhew CN, Cullen KE, et al. (2004). "HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin". J. Biol. Chem. 279 (11): 10551–5. doi:10.1074/jbc.M311719200. PMID 14707147.

인간 X 염색체 및/또는 그 관련 단백질에 대한 유전자에 대한 이 기사는 스터브다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000101811 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000031256 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1741396-5] Takagaki Y, MacDonald CC, Shenk T, Manley JL (March 1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc Natl Acad Sci U S A. 89 (4): 1403–7. Bibcode:1992PNAS...89.1403T. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396.

[entrez-6] "Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa".

[pmid10669729-7] Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729.

[pmid11389848-8] Calvo, O; Manley J L (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell. 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. ISSN 1097-2765. PMID 11389848.

[pmid11257228-9] Kleiman, F E; Manley J L (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. ISSN 0092-8674. PMID 11257228.

[pmid10477523-10] Kleiman, F E; Manley J L (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523.

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CSTF2

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