CASPase 모집 도메인 함유 단백질 11 은 CARD 함유 MAGUK 단백질 1 (Carma 1)이라고도 하며 CARD-CC 단백질 계열 의 단백질 로 인간 내에서는 CARD11 유전자 로 인코딩된다.[5] [6] [7]
함수 이 유전자가 인코딩한 단백질은 플라즈마 막의 전문 영역에서 다단백질 복합체의 조립을 위한 분자체로서 기능하는 단백질의 일종인 막 관련 구아닐레이트키나아제 (MAGUK) 계열에 속한다. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD ). CARD11 (CARMA1) has a domain structure similar to that of CARD10 (CARMA3) and CARD14 (CARMA2) as a member of the CARD-CC family with a C terminal MAGUK domain (the so-called CARMA proteins). CARD-CC 계열 의 단백질 CARD 영역은 특히 BCL10과 상호 작용하는 것으로 나타났는데, BCL10은 MALT1 의 모집과 활성화에 의해 세포 사멸과 NF-κB 활성화의 양성 조절기 역할을 하는 것으로 알려져 있다.세포에서 과다압축되면 이 단백질 계열은 NF-bB를 활성화하고 BCL10의 인산화 를 유도한다.[7]
CARD11은 T세포 와 B세포 기능에 중요하며 T세포 수용체 또는 B세포 수용체 자극 후 활성화된다. 수용체 자극 후, CARD11은 PKC-transmit (T cells) 또는 PKC-β (B cells)에 의해 인산염화된다. 인산화 작용은 BCL10과 MALT1 을 채용하는 필라멘트 CARD11 멀티머의 형성을 유도하여 NF-11 B를 활성화시킨다. CARD11의 기능 돌연변이는 적응면역 에 중요한 세포의 기능이 중단되기 때문에 심각한 결합면역결핍 (SCID)을 유발한다.
상호작용 CARD11은 BCL10과 상호작용 하는 것으로 나타났다.[8]
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