바쿠로바이러스 IAP 반복함유단백질3

BIRC3
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2UVL, 3EB5, 3EB6, 3M0A, 3M0D
식별자
에일리어스	3, IAP-1을 포함한 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2, 바쿨로바이러스 IAP 반복
외부 ID	OMIM: 601721 MGI: 1197007 HomoloGene: 899 GeneCard: BIRC3
유전자 위치(인간)
크르.	11번 염색체(인간)
끝.	102,339,403 bp
유전자 위치(마우스)
크르.	9번 염색체(쥐)
끝.	7,873,180 bp
RNA발현패턴
	상단 표시 위치:
	부록; ; 림프절; ; 비장; ; 담낭; ; 안검결막; ; 흉선; ; 직장; ; 천측두동맥; ; 아킬레스건; ; 위체;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	금속 이온 결합; 아포토시스 과정에 관여하는 시스테인형 엔도펩티드가수분해효소억제제 활성; GO:0001948 단백질 결합; 유비퀴틴산전달효소활성; 트랜스페라아제 활성; GO:1904264, GO:1904822, GO:0090622, GO:0090302 유비퀴틴단백질리가수분해효소활성;
셀룰러 컴포넌트	세포질; 핵소체; 막보트; 핵; 세포; 단백질 함유 복합체;
생물학적 과정	아포토시스 과정 조절; 시그널링 경로를 포함하는 뉴클레오티드 결합 올리고머화 도메인 조절; 선천성 면역 반응 조절; 톨라이크 수용체 시그널링 경로 조절; 괴사 과정의 음성 조절; 아포토시스 과정에 관여하는 시스테인형 엔도펩티드가수분해효소 활성 억제; 시스테인형 엔도펩티드가수분해효소활성조절; RIG-I 신호 경로 조절; 종양괴사인자결합신호경로조절; 아포토시스 과정의 음성 조절; 종양괴사인자결합신호경로; 유사분열 방추체; 세포표면수용체신호경로; NIK/NF-kappaB 시그널링; 정자 형성; 염증 반응 조절; I-kappaB인산화효소/NF-kappaB신호의 양성조절; I-kappaB인산화효소/NF-kappaB신호전달; 단백질 유비퀴티네이션의 양성 조절; 아포토시스 과정; 단백질유비퀴티네이션; 단백질탈유비퀴티네이션; 괴사 과정 조절; 단백질 헤테로올리구마화; MyD88의존성 톨라이크 수용체 시그널링 경로; TRIP의존성 톨라이크 수용체 시그널링 경로; 아포토시스 과정에 관여하는 시스테인형 엔도펩티드가수분해효소 활성의 음성 조절;
	출처:아미고 / QuickGO
맞춤법
	330
	11796
	ENSG000023445
	ENSMUSG000032000
	문제 13489
	O08863
	NM_001165; NM_182962
	NM_007464
	NP_001156; NP_892007
	NP_031490
	위키데이터
인간 보기/편집	마우스 표시/편집

Baculoviral IAP 반복 함유 단백질3(cIAP2)는 BIRC3 ^[5]^[6]유전자에 의해 인체에서 암호화되는 단백질이다.

cIAP2는 카스파아제 활성화를 방해함으로써 아포토시스를 억제하는 아포토시스 계열의 억제제이다.암호화된 단백질은 혈청 결핍에 의해 유도되는 아포토시스를 억제하지만 활성산소의 잠재적 유도물질인 메나디온에 노출되어 발생하는 아포토시스에는 영향을 미치지 않는다.cIAP2 단백질에는 UBA 도메인, CARD 도메인 및 RING 핑거 도메인의 3가지 BIR 도메인이 있습니다.동일한 isoform을 코드하는 트랜스크립트 바리안트가 ^[7]식별되었습니다.

상호 작용

Baculoviral IAP 반복 함유 단백질 3은 다음과 상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000023445 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032000 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (February 1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature. 379 (6563): 349–53. Bibcode:1996Natur.379..349L. doi:10.1038/379349a0. PMID 8552191. S2CID 4305853.
^ Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (February 1996). "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell. 83 (7): 1243–52. doi:10.1016/0092-8674(95)90149-3. PMID 8548810. S2CID 10694839.
^ "Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3".
^ Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. 17 (8): 2215–23. doi:10.1093/emboj/17.8.2215. PMC 1170566. PMID 9545235.
^ Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA (2008). "cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination". Mol. Cell. 30 (6): 689–700. doi:10.1016/j.molcel.2008.05.014. PMID 18570872.
^ ^a ^b Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
^ ^a ^b Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature. 416 (6878): 345–7. Bibcode:2002Natur.416..345L. doi:10.1038/416345a. PMID 11907583. S2CID 4325926.
^ Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL (1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. Bibcode:1996PNAS...93.4974U. doi:10.1073/pnas.93.10.4974. PMC 39390. PMID 8643514.
^ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917. S2CID 41164520.
^ Mace PD, Linke K, Feltham R, Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL (2008). "Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment". J. Biol. Chem. 283 (46): 31633–40. doi:10.1074/jbc.M804753200. PMID 18784070. S2CID 13619386.

추가 정보

Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma". Hematol. J. 3 (1): 10–3. doi:10.1038/sj.thj.6200146. PMID 11960389.
Uren AG, Pakusch M, Hawkins CJ, et al. (1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. Bibcode:1996PNAS...93.4974U. doi:10.1073/pnas.93.10.4974. PMC 39390. PMID 8643514.
Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG (1997). "Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization". Genomics. 37 (3): 404–6. doi:10.1006/geno.1996.0579. PMID 8938457.
Roy N, Deveraux QL, Takahashi R, et al. (1998). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
Deveraux QL, Roy N, Stennicke HR, et al. (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. 17 (8): 2215–23. doi:10.1093/emboj/17.8.2215. PMC 1170566. PMID 9545235.
Young SS, Liston P, Xuan JY, et al. (1999). "Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2". Mamm. Genome. 10 (1): 44–8. doi:10.1007/s003359900940. PMID 9892732. S2CID 7052915.
Horrevoets AJ, Fontijn RD, van Zonneveld AJ, et al. (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
Suzuki H, Motegi M, Akagi T, et al. (1999). "API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21)". Blood. 94 (9): 3270–1. doi:10.1182/blood.V94.9.3270. PMID 10610122.
Huang H, Joazeiro CA, Bonfoco E, et al. (2000). "The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7". J. Biol. Chem. 275 (35): 26661–4. doi:10.1074/jbc.C000199200. PMID 10862606.
Verhagen AM, Ekert PG, Pakusch M, et al. (2000). "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". Cell. 102 (1): 43–53. doi:10.1016/S0092-8674(00)00009-X. PMID 10929712. S2CID 3192775.
Baens M, Steyls A, Dierlamm J, et al. (2001). "Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type". Genes Chromosomes Cancer. 29 (4): 281–91. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1036>3.0.CO;2-I. PMID 11066071.
Werneburg BG, Zoog SJ, Dang TT, et al. (2001). "Molecular characterization of CD40 signaling intermediates". J. Biol. Chem. 276 (46): 43334–42. doi:10.1074/jbc.M104994200. PMID 11562359. S2CID 25436077.
Suzuki Y, Imai Y, Nakayama H, et al. (2001). "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death". Mol. Cell. 8 (3): 613–21. doi:10.1016/S1097-2765(01)00341-0. PMID 11583623.
Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature. 416 (6878): 345–7. Bibcode:2002Natur.416..345L. doi:10.1038/416345a. PMID 11907583. S2CID 4325926.
Gordon GJ, Appasani K, Parcells JP, et al. (2002). "Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma". Carcinogenesis. 23 (6): 1017–24. doi:10.1093/carcin/23.6.1017. PMID 12082024.
Sharief MK, Noori MA, Zoukos Y (2002). "Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy". J. Neuroimmunol. 129 (1–2): 224–31. doi:10.1016/S0165-5728(02)00185-6. PMID 12161039. S2CID 25809358.
Ekedahl J, Joseph B, Grigoriev MY, et al. (2002). "Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells". Exp. Cell Res. 279 (2): 277–90. doi:10.1006/excr.2002.5608. PMID 12243753.

외부 링크

UCSC Genome Browser의 인간 BIRC3 게놈 위치 및 BIRC3 유전자 상세 페이지.
PDB의 UniProt: Q13489(Baculoviral IAP 반복 함유 단백질 3)에서 PDBe-KB에 사용할 수 있는 모든 구조 정보의 개요.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000023445 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000032000 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8552191-5] Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (February 1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature. 379 (6563): 349–53. Bibcode:1996Natur.379..349L. doi:10.1038/379349a0. PMID 8552191. S2CID 4305853.

[pmid8548810-6] Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (February 1996). "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell. 83 (7): 1243–52. doi:10.1016/0092-8674(95)90149-3. PMID 8548810. S2CID 10694839.

[7] "Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3".

[pmid9545235-8] Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. 17 (8): 2215–23. doi:10.1093/emboj/17.8.2215. PMC 1170566. PMID 9545235.

[pmid18570872-9] Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA (2008). "cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination". Mol. Cell. 30 (6): 689–700. doi:10.1016/j.molcel.2008.05.014. PMID 18570872.

[pmid9384571-10] Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.

[pmid11907583-11] Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature. 416 (6878): 345–7. Bibcode:2002Natur.416..345L. doi:10.1038/416345a. PMID 11907583. S2CID 4325926.

[pmid8643514-12] Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL (1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. Bibcode:1996PNAS...93.4974U. doi:10.1073/pnas.93.10.4974. PMC 39390. PMID 8643514.

[pmid10753917-13] Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917. S2CID 41164520.

[pmid18784070-14] Mace PD, Linke K, Feltham R, Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL (2008). "Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment". J. Biol. Chem. 283 (46): 31633–40. doi:10.1074/jbc.M804753200. PMID 18784070. S2CID 13619386.

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바쿠로바이러스 IAP 반복함유단백질3

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레퍼런스

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