호모 사피엔스 종의 단백질 코드 유전자
아나베이스 촉진 복합체 서브유닛 7은 ANAPC7 [5] 유전자에 의해 인체 내에서 부호화되는 효소 이다.이 유전자에 대해 서로 다른 아이소폼을 코드하는 여러 개의 전사 변형이 발견되었다.
기능. 이 유전자는 26S 프로테아솜 매개 분해를 위해 B형 사이클린 등 다수의 세포주기 조절제를 표적으로 하여 세포주기 진행을 제어 하는 대형 E3 유비퀴틴 연결효소 인 아나베이스 촉진복합체 /시클로좀(APC/C) 성분을 포함한 테트라트리코펩티드 반복체를 코드한다. 암호화 단백질은 APC/C의 적절한 단백질 유비퀴티네이션 기능 및 APC/C와 특정 전사 공활성제 의 [5] 상호작용에 필요하다.
상호 작용 ANAPC7은 ANAPC1 ,[6] [7] ANAPC4 ,[6] CDC27 [6] [8] 및 CDC20 과 [6] [9] 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000196510 - 앙상블 , 2017년 5월 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029466 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ a b "Entrez Gene: ANAPC7 anaphase promoting complex subunit 7" . ^ a b c d Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68. doi :10.1016/S0960-9822(03)00581-5 . PMID 12956947 . S2CID 5942532 . ^ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase" . J. Cell Biol . 151 (4): 749–62. doi :10.1083/jcb.151.4.749 . PMC 2169443 . PMID 11076961 . ^ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proc. Natl. Acad. Sci. U.S.A . 97 (16): 8973–8. doi :10.1073/pnas.97.16.8973 . PMC 16806 . PMID 10922056 . ^ Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction" . Nat. Cell Biol . 10 (12): 1411–20. doi :10.1038/ncb1799 . PMC 2635557 . PMID 18997788 . 외부 링크
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