호모 사피엔스 종의 단백질 코드 유전자
아나베이스 촉진 복합체 서브유닛 4는 ANAPC4 [5] [6] 효소 이다.
아나파기촉진복합체(APC) 또는 사이클로솜이라고 불리는 대형 단백질 복합체는 유사분열성 사이클린 및 아나파기 억제제 등의 특정 기질을 유비쿼티화함으로써 메타파기-아나파기 전이를 촉진하고, 이들 기질은 26S 프로테아솜에 의해 그 후에 분해된다. 생화학적 연구는 척추동물 APC가 8개의 서브유닛을 포함하고 있다는 것을 보여준다. APC의 조성은 효모에서 인간에 이르는 유기체에서 매우 잘 보존된다. 이 유전자 생성물의 정확한 기능은 [6]
상호 작용 ANAPC4는 ANAPC1 ,[7] [8] ANAPC5 ,[7] CDC27 [7] [9] [7] ANAPC7 과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000053900 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029176 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tekolf WA, Biddison WE, Aster RD, Shaw S (October 1982). "Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium". J Immunol . 129 (4): 1474–8. PMID 6180011 . ^ a b "Entrez Gene: ANAPC4 anaphase promoting complex subunit 4" .^ a b c d Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68. doi :10.1016/S0960-9822(03)00581-5 ISSN 0960-9822 . PMID 12956947 . S2CID 5942532 . ^ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase" . J. Cell Biol . 151 (4): 749–62. doi :10.1083/jcb.151.4.749 . ISSN 0021-9525 . PMC 2169443 PMID 11076961 . ^ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode :2000PNAS...97.8973G . doi :10.1073/pnas.97.16.8973 ISSN 0027-8424 . PMC 16806 PMID 10922056 .
외부 링크 추가 정보 Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Yu H, Peters JM, King RW, et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science . 279 (5354): 1219–22. Bibcode :1998Sci...279.1219Y . doi :10.1126/science.279.5354.1219 . PMID 9469815 . Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex" . J. Biol. Chem . 274 (20): 14500–7. doi :10.1074/jbc.274.20.14500 PMID 10318877 . Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons" . Proc. Natl. Acad. Sci. U.S.A . 96 (20): 11317–22. Bibcode :1999PNAS...9611317G . doi :10.1073/pnas.96.20.11317 PMC 18031 PMID 10500174 . Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proc. Natl. Acad. Sci. U.S.A . 97 (16): 8973–8. Bibcode :2000PNAS...97.8973G . doi :10.1073/pnas.97.16.8973 PMC 16806 PMID 10922056 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68. doi :10.1016/S0960-9822(03)00581-5 PMID 12956947 . S2CID 5942532 . Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation" . EMBO J . 22 (24): 6598–609. doi :10.1093/emboj/cdg627 . PMC 291822 PMID 14657031 . Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science . 302 (5653): 2141–4. Bibcode :2003Sci...302.2141J . doi :10.1126/science.1090100 . PMID 14684825 . S2CID 10007258 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 .
