호모 사피엔스 종의 단백질 코드 유전자
아나베이스 촉진 복합체 서브유닛 1은 ANAPC1 [5] [6] 효소 이다.
ANAPC1은 세포주기 의 중기 에서 아나파기로의 이행으로 기능하며 방추체크포인트 단백질에 의해 조절되는 아나파기촉진복합체 (APC)의 적어도 10개의 서브유닛 중 하나이다. APC는 E3 유비퀴틴 연결효소 로서 프로테아솜 에 의해 분해되는 세포 주기 조절 단백질을 목표로 하여 세포 주기(OMIM 에 [6]
상호 작용 ANAPC1은 ANAPC5 ,[7] [8] ANAPC4 ,[7] [8] ANAPC2 ,[7] [8] CDC27 [7] [8] [7] [8] ANAPC7 과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000153107 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000014355 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene . 262 (1–2): 51–9. doi :10.1016/S0378-1119(00)00511-4 . PMID 11179667 . ^ a b "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1" .^ a b c d e Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68. doi :10.1016/S0960-9822(03)00581-5 ISSN 0960-9822 . PMID 12956947 . S2CID 5942532 . ^ a b c d e Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase" . J. Cell Biol . 151 (4): 749–62. doi :10.1083/jcb.151.4.749 . ISSN 0021-9525 . PMC 2169443 PMID 11076961 .
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