XAF1

XAF1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2LXW
식별자
에일리어스	XAF1, BIRC4BP, HSXIAPAF1, XIAPAF1, XIAP 관련 팩터1
외부 ID	OMIM: 606717 MGI: 3772572 HomoloGene: 49488 GeneCard: XAF1
유전자 위치(인간)
크르.	17번 염색체(인간)
끝.	6,775,647 bp
유전자 위치(마우스)
크르.	11번 염색체(쥐)
끝.	72,440,559 bp
RNA발현패턴
	상단 표시 위치:
	담낭; ; 우측 자궁관; ; 단구; ; 간우엽; ; 내장 흉막; ; 비장; ; 내피 세포; ; 자궁경관; ; 두정 흉막; ; 우관상 동맥;
	상단 표시 위치:
	자궁경부; ; 오른쪽 폐; ; 우폐엽; ; 피하 지방 조직; ; 경동맥체; ; 좌골 신경; ; 십이지장; ; 턱밑샘; ; 흉선; ; 칼바리아;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	금속 이온 결합; 아연 이온 결합;
셀룰러 컴포넌트	세포; 세포질; 핵; 미토콘드리아;
생물학적 과정	아포토시스 과정; I형 인터페론 신호 경로; 인터페론의 매개에 의한 반응;
	출처:아미고 / QuickGO
맞춤법
	54739
	327959
	ENSG00000132530
	ENSMUSG000040483
	Q6GPH4
	문제 5 NBU8
NM_017523; NM_199139; NM_001353134; NM_001353135; NM_001353136;
	NM_001353137; NM_001353138; NM_001353139; NM_001353140
	NM_001037713; NM_001291153
NP_059993; NP_954590; NP_001340063; NP_001340064; NP_001340065;
	NP_001340066; NP_001340067; NP_001340068; NP_001340069
	NP_001032802; NP_001278082
	위키데이터
인간 보기/편집	마우스 표시/편집

XIAP 관련인자 1은 XAF1 ^[5]^[6]^[7]유전자에 의해 인간에서 암호화되는 단백질이다.

기능.

X-연결 아포토시스 억제제(XIAP; MIM 300079)는 IAP 계열의 유력한 구성원이다.이 패밀리의 모든 구성원은 카스파아제(예: CASP3; MIM 600636)와 결합하고 억제하는 약 80개의 아미노산의 시스테인이 풍부한 바쿨로바이러스 IAP(BIR) 반복 도메인을 가지고 있다.XIAP에는 3개의 BIR 도메인과 E3 유비퀴틴 리가아제(MIM 601623 참조) 활성을 가진 C-말단 RING 아연 핑거가 있습니다.XAF1은 XIAP의 항아스피아제 활성을 길들이고 암세포에서 아포토시스 내성을 매개하는 데 중요할 수 있다(Liston 등, 2001).[OMIM ^[7]제공]

상호 작용

XAF1은 XIAP와 ^[6]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000132530 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000040483 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC (Aug 2002). "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis". J. Biol. Chem. 277 (32): 28504–11. doi:10.1074/jbc.M204851200. PMID 12029096.
^ ^a ^b Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, Tamai K, Craig CG, McBurney MW, Korneluk RG (Feb 2001). "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity". Nat. Cell Biol. 3 (2): 128–33. doi:10.1038/35055027. PMID 11175744. S2CID 19731886.
^ ^a ^b "Entrez Gene: XAF1 XIAP associated factor-1".

추가 정보

Fong WG, Liston P, Rajcan-Separovic E, St Jean M, Craig C, Korneluk RG (2000). "Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines". Genomics. 70 (1): 113–22. doi:10.1006/geno.2000.6364. PMID 11087668.
Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR, Chi SG (2003). "Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas". Cancer Res. 63 (21): 7068–75. PMID 14612497.
Ng KC, Campos EI, Martinka M, Li G (2004). "XAF1 expression is significantly reduced in human melanoma". J. Invest. Dermatol. 123 (6): 1127–34. doi:10.1111/j.0022-202X.2004.23467.x. PMID 15610524.
Wang J, He H, Yu L, Xia HH, Lin MC, Gu Q, Li M, Zou B, An X, Jiang B, Kung HF, Wong BC (2006). "HSF1 down-regulates XAF1 through transcriptional regulation". J. Biol. Chem. 281 (5): 2451–9. doi:10.1074/jbc.M505890200. PMID 16303760.
Yin W, Cheepala S, Clifford JL (2006). "Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1". Biochem. Biophys. Res. Commun. 339 (4): 1148–54. doi:10.1016/j.bbrc.2005.11.128. PMID 16343440.
Fang X, Liu Z, Fan Y, Zheng C, Nilson S, Egevad L, Ekman P, Xu D (2006). "Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor". Int. J. Cancer. 118 (10): 2485–9. doi:10.1002/ijc.21636. PMID 16353137. S2CID 43629966.
Gilli F, Marnetto F, Caldano M, Sala A, Malucchi S, Capobianco M, Bertolotto A (2006). "Biological markers of interferon-beta therapy: comparison among interferon-stimulated genes MxA, TRAIL and XAF-1". Mult. Scler. 12 (1): 47–57. doi:10.1191/135248506ms1245oa. PMID 16459719. S2CID 34530563.
Reu FJ, Bae SI, Cherkassky L, Leaman DW, Lindner D, Beaulieu N, MacLeod AR, Borden EC (2006). "Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation". J. Clin. Oncol. 24 (23): 3771–9. CiteSeerX 10.1.1.1025.9291. doi:10.1200/JCO.2005.03.4074. PMID 16801630.
Lee MG, Huh JS, Chung SK, Lee JH, Byun DS, Ryu BK, Kang MJ, Chae KS, Lee SJ, Lee CH, Kim JI, Chang SG, Chi SG (2006). "Promoter CpG hypermethylation and downregulation of XAF1 expression in human urogenital malignancies: implication for attenuated p53 response to apoptotic stresses". Oncogene. 25 (42): 5807–22. doi:10.1038/sj.onc.1209867. PMID 16909101.
Zou B, Chim CS, Zeng H, Leung SY, Yang Y, Tu SP, Lin MC, Wang J, He H, Jiang SH, Sun YW, Yu LF, Yuen ST, Kung HF, Wong BC (2006). "Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers". Gastroenterology. 131 (6): 1835–43. doi:10.1053/j.gastro.2006.09.050. PMID 17087954.
Micali OC, Cheung HH, Plenchette S, Hurley SL, Liston P, LaCasse EC, Korneluk RG (2007). "Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta". BMC Cancer. 7: 52. doi:10.1186/1471-2407-7-52. PMC 1845166. PMID 17376236.
Kempkensteffen C, Hinz S, Schrader M, Christoph F, Magheli A, Krause H, Schostak M, Miller K, Weikert S (2007). "Gene expression and promoter methylation of the XIAP-associated Factor 1 in renal cell carcinomas: correlations with pathology and outcome". Cancer Lett. 254 (2): 227–35. doi:10.1016/j.canlet.2007.03.006. PMID 17449173.
Shibata T, Mahotka C, Wethkamp N, Heikaus S, Gabbert HE, Ramp U (2007). "Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomas". Diagn. Mol. Pathol. 16 (1): 1–8. doi:10.1097/01.pdm.0000213471.92925.51. PMID 17471152. S2CID 43822747.
Chung SK, Lee MG, Ryu BK, Lee JH, Han J, Byun DS, Chae KS, Lee KY, Jang JY, Kim HJ, Chi SG (2007). "Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses". Gastroenterology. 132 (7): 2459–77. doi:10.1053/j.gastro.2007.04.024. PMID 17570219.
Arora V, Cheung HH, Plenchette S, Micali OC, Liston P, Korneluk RG (2007). "Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex". J. Biol. Chem. 282 (36): 26202–9. doi:10.1074/jbc.M700776200. PMID 17613533.

인간 염색체 17번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000132530 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000040483 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12029096-5] Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC (Aug 2002). "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis". J. Biol. Chem. 277 (32): 28504–11. doi:10.1074/jbc.M204851200. PMID 12029096.

[pmid11175744-6] Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, Tamai K, Craig CG, McBurney MW, Korneluk RG (Feb 2001). "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity". Nat. Cell Biol. 3 (2): 128–33. doi:10.1038/35055027. PMID 11175744. S2CID 19731886.

[entrez-7] "Entrez Gene: XAF1 XIAP associated factor-1".

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XAF1

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목차

기능.

상호 작용

레퍼런스

추가 정보