UQCR11

UQCR11
UQCR11
식별자
에일리어스UQCR11, 0710008D09Rik, QCR10, UQCR, 유비퀴놀시토크롬c환원효소, 복합 III 서브유닛 XI
외부 IDOMIM: 609711 MGI: 1913844 HomoloGene: 4974 GeneCard: UQCR11
맞춤법
종.인간마우스
엔트레즈

10975

66594

앙상블

ENSG00000127540

ENSMUSG000020163

유니프로트

O14957

Q9CPX8

RefSeq(mRNA)

NM_006830

NM_025650

RefSeq(단백질)

NP_006821

NP_079926

장소(UCSC)Chr 19: 1.6~1.61 MbChr 10: 80.24 ~80.24 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

UQCR11(유비퀴놀-시토크롬c 환원효소, 복합체 III 서브유닛 XI)은 UQCR11 [5][6]유전자에 의해 인체에서 코드되는 단백질이다.UQCR11은 미토콘드리아 호흡 [6]사슬에서 복합체 III의 가장 작은 성분으로 알려져 있다.

구조.

UQCR11 유전자는 염색체 19의 p팔 위치 13.3에 위치하고 있으며,[6] 3개의 엑손으로 구성되어 있으며 길이는 8,329쌍이다.UQCR11 단백질의 무게는 6.6kDa이며 56개의 [7][8]아미노산으로 구성되어 있습니다.이 유전자는 복합체 III로도 알려져 있고 미토콘드리아 호흡 사슬의 [6]일부인 유비퀴놀-시토크롬 c 환원효소 복합체의 알려진 가장 작은 성분을 암호화합니다.척추동물에서 복합체 III는 3개의 호흡 서브 유닛, 2개의 핵심 단백질, 6개의 저분자량 [9][10]단백질 등 11개의 서브 유닛을 포함합니다.프로테오박테리아 복합체는 3개의 서브유닛을 [11]포함할 수 있습니다.

Function

The UQCR11 protein may function as a binding factor for the iron-sulfur protein in Complex III, which is ubiquitous in human cells.[6] Complex III catalyzes the chemical reaction

QH2 + 2 ferricytochrome c Q + 2 ferrocytochrome c + 2 H+

Thus, the two substrates of Complex III are dihydroquinone (QH2) and ferri- (Fe3+) cytochrome c, whereas its 3 products are quinone (Q), ferro- (Fe2+) cytochrome c, and H+. This complex belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with a cytochrome as acceptor. This enzyme participates in oxidative phosphorylation. It has four cofactors: cytochrome c1, cytochrome b-562, cytochrome b-566 and a 2-Iron ferredoxin of the Rieske type.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127540 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020163 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Eisenberg E, Levanon EY (July 2003). "Human housekeeping genes are compact". Trends in Genetics. 19 (7): 362–365. arXiv:q-bio/0309020. Bibcode:2003q.bio.....9020E. doi:10.1016/S0168-9525(03)00140-9. PMID 12850439. S2CID 7728312.
  6. ^ a b c d e "Entrez Gene: UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI".
  7. ^ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
  8. ^ "Cytochrome b-c1 complex subunit 11". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).
  9. ^ Zhang Z, Huang L, Shulmeister VM, Chi YI, Kim KK, Hung LW, et al. (1998). "Electron transfer by domain movement in cytochrome bc1". Nature. 392 (6677): 677–84. Bibcode:1998Natur.392..677Z. doi:10.1038/33612. PMID 9565029. S2CID 4380033.
  10. ^ Hao GF, Wang F, Li H, Zhu XL, Yang WC, Huang LS, et al. (2012). "Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex". J Am Chem Soc. 134 (27): 11168–76. doi:10.1021/ja3001908. PMID 22690928.
  11. ^ Yang XH, Trumpower BL (1986). "Purification of a three-subunit ubiquinol-cytochrome c oxidoreductase complex from Paracoccus denitrificans". J Biol Chem. 261 (26): 12282–9. doi:10.1016/S0021-9258(18)67236-9. PMID 3017970.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.