BRCA1-A 복합 서브유닛 RAP80은 인체 내 에서 UIMC1 [5] [6] 단백질 이다.
DNA 손상 복구 UIMC1 유전자의 단백질 생성물인 RAB80은 데우비퀴틴 복합체 BRCA1-A의 [7] BRCA1-A 복합체의 다른 핵심 구성 요소는 BRCC36 단백질(BRC3 유전자), BRE 단백질(BRE(유전자 ), MERIT40 단백질(BAB)이다. AM1 유전자).[7]
BRCA1-A와 구별되는 BRCA1 은 DNA 이중사슬 파괴의 오류 없는 상동재조합 (HR) 복구에 중요한 역할을 하는 염색체 손상 복구에 사용된다. BRCA1을 DNA 손상 부위로부터 격리함으로써 상동 재조합을 억제하고 비상동 말단 결합(NHEJ)[7] BRCA1-A 복합체의 역할은 높은 친화력으로 BRCA1을 결합하고 DNA 손상 부위에서 격리된 상태로 있는 주변부로 철수시켜 NHEJ를 HR보다 우선적으로 촉진하는 것으로 보인다.
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