TAC3

TAC3
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1P9F
식별자
에일리어스	TAC3, HH10, NKB, NKNB, PRO1155, ZNEUROK1, 타키키닌3, 타키키닌 전구체3, NK3, LncZBTB39
외부 ID	OMIM: 162330 MGI: 98476 HomoloGene: 7560 GeneCard: TAC3
유전자 위치(인간)
크르.	12번 염색체(인간)
끝.	57,028,883 bp
유전자 위치(마우스)
크르.	10번 염색체(쥐)
끝.	127,567,637 bp
RNA발현패턴
	상단 표시 위치:
	미산핵; ; 전전두피질; ; 핵액컴벤스; ; 배측 전전두피질; ; 창호; ; 브로드만 9구역; ; 정강이뼈전근; ; 내피 세포; ; 브로드만 영역 46; ; 시상하부;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	신호수용체결합; GO:0001948 단백질 결합; 뉴로메딘K수용체결합; 물질K수용체결합;
셀룰러 컴포넌트	세포외 영역; 세포외 공간;
생물학적 과정	여성 임신; 신경펩티드신호경로; 타키키닌수용체신호경로; 편모 정자 운동성의 양성 조절; G단백질결합수용체신호경로;
	출처:아미고 / QuickGO
맞춤법
	6866
	21334
	ENSG00000166863
	ENSMUSG000025400
	Q9UHF0
	P55099
	NM_001006667; NM_001178054; NM_013251
	NM_001199971; NM_009312
	NP_001171525; NP_037383
	NP_001186900; NP_033338
	위키데이터
인간 보기/편집	마우스 표시/편집

타키키닌-3는 인간의 TAC3 ^[5]^[6]^[7]유전자에 의해 암호화되는 단백질이다.

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레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000166863 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025400 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bonner TI, Affolter HU, Young AC, Young WS (Jan 1988). "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B". Brain Res. 388 (3): 243–9. doi:10.1016/0169-328x(87)90031-3. PMID 3479225.
^ Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ (Jul 2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia". Nature. 405 (6788): 797–800. Bibcode:2000Natur.405..797P. doi:10.1038/35015579. PMID 10866201. S2CID 4392048.
^ "Entrez Gene: TAC3 tachykinin 3 (neuromedin K, neurokinin beta)".

추가 정보

Page NM, Woods RJ, Lowry PJ (2001). "A regulatory role for neurokinin B in placental physiology and pre-eclampsia". Regul. Pept. 98 (3): 97–104. doi:10.1016/S0167-0115(00)00239-1. PMID 11231038. S2CID 7160887.
Rance NE, Young WS (1991). "Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women". Endocrinology. 128 (5): 2239–47. doi:10.1210/endo-128-5-2239. PMID 1708331.
Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. Chem. 269 (44): 27269–74. doi:10.1016/S0021-9258(18)46979-7. PMID 7961636.
Tian Y, Wu LH, Oxender DL, Chung FZ (1996). "The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity". J. Biol. Chem. 271 (34): 20250–7. doi:10.1074/jbc.271.34.20250. PMID 8702757.
Krause JE, Staveteig PT, Mentzer JN, et al. (1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds 3Hsenktide and 125I-MePhe7neurokinin B, and is responsive to tachykinin peptide agonists". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 310–5. doi:10.1073/pnas.94.1.310. PMC 19326. PMID 8990205.
Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis". Neuropeptides. 32 (3): 215–23. doi:10.1016/S0143-4179(98)90040-3. PMID 10189055. S2CID 40222022.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brownbill P, Bell NJ, Woods RJ, et al. (2003). "Neurokinin B is a paracrine vasodilator in the human fetal placental circulation". J. Clin. Endocrinol. Metab. 88 (5): 2164–70. doi:10.1210/jc.2002-021727. PMID 12727971.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Schlembach D, Scalera F, Fischer T, et al. (2003). "Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women". Am. J. Obstet. Gynecol. 189 (5): 1418–22. doi:10.1067/S0002-9378(03)00775-0. PMID 14634580.
Laliberte C, DiMarzo L, Morrish DW, Kaufman S (2004). "Neurokinin B causes concentration-dependent relaxation of isolated human placental resistance vessels". Regul. Pept. 117 (2): 123–6. doi:10.1016/j.regpep.2003.10.032. PMID 14700748. S2CID 25577867.
Pal S, Nemeth MJ, Bodine D, et al. (2004). "Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1". J. Biol. Chem. 279 (30): 31348–56. doi:10.1074/jbc.M403475200. PMID 15123623.
Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM (2005). "Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles". J. Biomol. Struct. Dyn. 22 (2): 137–48. doi:10.1080/07391102.2004.10506990. PMID 15317475. S2CID 41064499.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Page NM, Dakour J, Morrish DW (2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia". Mol. Hum. Reprod. 12 (7): 427–33. doi:10.1093/molehr/gal025. PMID 16709596.

인간 염색체 12번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000166863 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000025400 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3479225-5] Bonner TI, Affolter HU, Young AC, Young WS (Jan 1988). "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B". Brain Res. 388 (3): 243–9. doi:10.1016/0169-328x(87)90031-3. PMID 3479225.

[pmid10866201-6] Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ (Jul 2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia". Nature. 405 (6788): 797–800. Bibcode:2000Natur.405..797P. doi:10.1038/35015579. PMID 10866201. S2CID 4392048.

[entrez-7] "Entrez Gene: TAC3 tachykinin 3 (neuromedin K, neurokinin beta)".

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