SIRT4 로도 알려진 Sirtuin 4는 사람 에게서 SIRT4 [5] [6] 미토콘드리아 단백질 이다.SIRT4는 효모 Sir2 단백질의 상동어 인 포유동물 Sirtuin 계열의 단백질이다. SIRT4는 NAD+의존성 탈아세틸화효소 활성을 나타낸다.
기능. SIRT4는 미토콘드리아 글루탐산탈수소효소 1의 활성을 억제하여 아미노산에 [7] 억제 하는 미토콘드리아 ADP-리보실전달효소이다. SIRT4에 의한 말로닐-CoA 탈탄산화효소 탈아세틸화 는 효소 활성을 억제하여 근육 [8] [9] 지방산 산화를 저해 한다. SIRT4는 간세포의 [9] 하향 조절하는 페르옥시좀 증식기 활성화 수용체 알파(PPAR-α)에 억제 효과가 있다. ADP/ ATP 트랜스로카아제2 (ANT2)의 탈아세틸화 는 미토콘드리아 [9] 분리 를 감쇠시킴으로써 세포 ATP를 증가시킨다.
임상적 의의 SIRT4는 미토콘드리아 종양 억제 [9] SIRT4의 과잉발현 은 글루타민 대사 [9] [10]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000089163 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029524 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Frye RA (June 1999). "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity". Biochem. Biophys. Res. Commun . 260 (1): 273–79. doi :10.1006/bbrc.1999.0897 . PMID 10381378 . ^ "Entrez Gene: Sirtuin 4" .^ Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L (September 2006). "SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells" . Cell . 126 (5): 941–54. doi :10.1016/j.cell.2006.06.057 PMID 16959573 . S2CID 1391160 . ^ Nasrin N, Wu X, Fortier E, Feng Y, Bare' OC, Chen S, Ren X, Wu Z, Streeper RS, Bordone L (October 2010). "SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. In primary myotubes and hepatocytes, knockdown of SIRT4 results in increased Fatty Acid Oxidation, cellular respiration, and pAMPK levels. SIRT4 inhibition increases fat oxidative capacity in liver and mitochondrial function in muscle, which might provide therapeutic benefits for diseases associated with ectopic lipid storage such as type 2 diabetes" . J. Biol. Chem . 285 (42): 31995–32002. doi :10.1074/jbc.M110.124164 PMC 2952200 PMID 20685656 . ^ a b c d e Li S, Zheng W (2018). "Mammalian Sirtuins SIRT4 and SIRT7". Progress in Biophysics and Molecular Biology 154 : 147–168. doi :10.1016/bs.pmbts.2017.11.001 . ISBN 9780128122617 PMID 29413176 . ^ Yoo HC, Yu YC, Sung Y, Han JM (2020). "Glutamine reliance in cell metabolism" . Experimental & Molecular Medicine 52 (9): 1496–1516. doi :10.1038/s12276-020-00504-8 PMC 8080614 PMID 32943735 . 추가 정보 Yamamoto H, Schoonjans K, Auwerx J (2007). "Sirtuin functions in health and disease" . Mol. Endocrinol . 21 (8): 1745–55. doi :10.1210/me.2007-0079 PMID 17456799 . Michishita E, Park JY, Burneskis JM, et al. (2005). "Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins" . Mol. Biol. Cell . 16 (10): 4623–35. doi :10.1091/mbc.E05-01-0033 . PMC 1237069 PMID 16079181 . Reiling E, van Vliet-Ostaptchouk JV, van 't Riet E, et al. (2009). "Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study" . Eur. J. Hum. Genet . 17 (8): 1056–62. doi :10.1038/ejhg.2009.4 . PMC 2986549 PMID 19209188 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–27. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ahuja N , Schwer B, Carobbio S, et al. (2007). "Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase" . J. Biol. Chem . 282 (46): 33583–92. doi :10.1074/jbc.M705488200 PMID 17715127 .Sanger Centre, The; Washington University Genome Sequencing Cente, The (1998). "Toward a complete human genome sequence" . Genome Res . 8 (11): 1097–108. doi :10.1101/gr.8.11.1097 PMID 9847074 . Frye RA (2000). "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins". Biochem. Biophys. Res. Commun . 273 (2): 793–98. doi :10.1006/bbrc.2000.3000 . PMID 10873683 . Irobi J, Van Impe K, Seeman P, et al. (2004). "Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy" . Nat. Genet . 36 (6): 597–601. doi :10.1038/ng1328 PMID 15122253 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12" . Nature . 440 (7082): 346–51. Bibcode :2006Natur.440..346S . doi :10.1038/nature04569 PMID 16541075 . 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
