RNPS1

RNPS1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	4A8X
식별자
에일리어스	세린 리치 도메인 1을 가진 RNPS1, E5.1, RNA결합단백질
외부 ID	OMIM: 606447 MGI: 97960 HomoloGene: 40648 GeneCard: RNPS1
유전자 위치(인간)
크르.	16번 염색체(인간)
끝.	2,268,397 bp
유전자 위치(마우스)
크르.	17번 염색체(쥐)
끝.	24,644,875 bp
RNA발현패턴
	상단 표시 위치:
	소뇌 반구; ; 신경절 융기; ; 위근; ; 브로드만 10구역; ; 뇌하수체 전엽; ; 좌측 자궁관; ; 자궁경관; ; 복부 피부; ; 전두극; ; 슬와 동맥;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	mRNA3'-UTR결합; GO:0001948 단백질 결합; RNA결합; 핵산 결합;
셀룰러 컴포넌트	세포질; 세포; 핵반점; 엑손-엑손 접합 착화체; 핵소체; ASAP 컴플렉스; 핵;
생물학적 과정	mRNA 스플라이싱, 스플라이싱 경유; RNA중합효소II 전사종료; mRNA 처리; 스플라이소솜을 통한 대체 mRNA 스플라이싱 조절; 핵으로부터의 mRNA 내보내기; 전사, DNA 템플릿; 스플라이소솜을 통한 mRNA 스플라이싱의 음성 조절; RNA 스플라이싱; 아포토시스 과정의 양성 조절; 핵변환 mRNA 이화 과정, 난센스 매개 붕괴; mRNA 3' 엔드 처리; 핵으로부터의 RNA 내보내기;
	출처:아미고 / QuickGO
맞춤법
	10921
	19826
	ENSG00000205937
	ENSMUSG000034681
	문제 15287
	문제 99M28
	NM_001286625; NM_001286626; NM_001286627; NM_006711; NM_080594
	NM_001080127; NM_001080128; NM_009070; NM_001357626
	NP_001273554; NP_001273555; NP_001273556; NP_006702; NP_542161
	NP_001073596; NP_001073597; NP_033096; NP_001344555
	위키데이터
인간 보기/편집	마우스 표시/편집

세린이 풍부한 도메인 1을 가진 RNA결합단백질은 RNPS1 ^[5]^[6]^[7]유전자에 의해 인체 내에서 암호화되는 단백질이다.

기능.

이 유전자는 mRNA 핵수출과 mRNA 감시에 모두 관여하는 스플라이싱 후 다단백질 복합체인 엑손 접합 복합체의 일부인 단백질을 암호화한다.mRNA 감시는 잘린 개방 판독 프레임으로 수출된 mRNA를 검출하여 넌센스 매개 mRNA 붕괴(NMD)를 개시한다.변환이 마지막 exon-exon 접합에서 업스트림으로 종료되면 NMD는 조기정지 코돈을 포함한 mRNA를 열화시킵니다.이 단백질은 mRNA에 결합하고 핵 수출 후에도 결합을 유지하며 핵 세포질 폐쇄 단백질로 작용합니다.이 단백질에는 세린 잔기가 많이 함유되어 있습니다.이 유전자에 대해 두 개의 스플라이스 변형이 발견되었으며, 두 변종 모두 동일한 ^[7]단백질을 암호화합니다.

상호 작용

RNPS1은 SART3^[8] 및 Pinin과 ^[9]^[10]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000205937 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000034681 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loyer P, Trembley JH, Lahti JM, Kidd VJ (Jun 1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo". Journal of Cell Science. 111 ( Pt 11) (11): 1495–506. doi:10.1242/jcs.111.11.1495. PMID 9580558.
^ Badolato J, Gardiner E, Morrison N, Eisman J (Dec 1995). "Identification and characterisation of a novel human RNA-binding protein". Gene. 166 (2): 323–7. doi:10.1016/0378-1119(95)00571-4. PMID 8543184.
^ ^a ^b "Entrez Gene: RNPS1 RNA binding protein S1, serine-rich domain".
^ Harada K, Yamada A, Yang D, Itoh K, Shichijo S (Sep 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570. S2CID 24724555.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Li C, Lin RI, Lai MC, Ouyang P, Tarn WY (Oct 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Molecular and Cellular Biology. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. PMC 230327. PMID 14517304.

추가 정보

Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (Jun 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Research. 6 (6): 525–37. doi:10.1101/gr.6.6.525. PMID 8828041.
Wilson KF, Fortes P, Singh US, Ohno M, Mattaj IW, Cerione RA (Feb 1999). "The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction". The Journal of Biological Chemistry. 274 (7): 4166–73. doi:10.1074/jbc.274.7.4166. PMID 9933612.
Mayeda A, Badolato J, Kobayashi R, Zhang MQ, Gardiner EM, Krainer AR (Aug 1999). "Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing". The EMBO Journal. 18 (16): 4560–70. doi:10.1093/emboj/18.16.4560. PMC 1171530. PMID 10449421.
Le Hir H, Izaurralde E, Maquat LE, Moore MJ (Dec 2000). "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions". The EMBO Journal. 19 (24): 6860–9. doi:10.1093/emboj/19.24.6860. PMC 305905. PMID 11118221.
Harada K, Yamada A, Yang D, Itoh K, Shichijo S (Sep 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570. S2CID 24724555.
Kim VN, Kataoka N, Dreyfuss G (Sep 2001). "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex". Science. 293 (5536): 1832–6. Bibcode:2001Sci...293.1832K. doi:10.1126/science.1062829. PMID 11546873. S2CID 12018200.
Lykke-Andersen J, Shu MD, Steitz JA (Sep 2001). "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1". Science. 293 (5536): 1836–9. Bibcode:2001Sci...293.1836L. doi:10.1126/science.1062786. PMID 11546874. S2CID 389385.
Lejeune F, Ishigaki Y, Li X, Maquat LE (Jul 2002). "The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling". The EMBO Journal. 21 (13): 3536–45. doi:10.1093/emboj/cdf345. PMC 126094. PMID 12093754.
McCracken S, Longman D, Johnstone IL, Cáceres JF, Blencowe BJ (Nov 2003). "An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation". The Journal of Biological Chemistry. 278 (45): 44153–60. doi:10.1074/jbc.M306856200. PMID 12944400.
Li C, Lin RI, Lai MC, Ouyang P, Tarn WY (Oct 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Molecular and Cellular Biology. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. PMC 230327. PMID 14517304.
Kataoka N, Dreyfuss G (Feb 2004). "A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex". The Journal of Biological Chemistry. 279 (8): 7009–13. doi:10.1074/jbc.M307692200. PMID 14625303.
Sakashita E, Tatsumi S, Werner D, Endo H, Mayeda A (Feb 2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Molecular and Cellular Biology. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
Nott A, Le Hir H, Moore MJ (Jan 2004). "Splicing enhances translation in mammalian cells: an additional function of the exon junction complex". Genes & Development. 18 (2): 210–22. doi:10.1101/gad.1163204. PMC 324426. PMID 14752011.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.

외부 링크

PDB의 UniProt: Q15287(세린이 풍부한 도메인 1)에 대한 PDB의 모든 구조 정보의 개요.

이 단백질 관련 기사는 스텁입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000205937 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000034681 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9580558-5] Loyer P, Trembley JH, Lahti JM, Kidd VJ (Jun 1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo". Journal of Cell Science. 111 ( Pt 11) (11): 1495–506. doi:10.1242/jcs.111.11.1495. PMID 9580558.

[pmid8543184-6] Badolato J, Gardiner E, Morrison N, Eisman J (Dec 1995). "Identification and characterisation of a novel human RNA-binding protein". Gene. 166 (2): 323–7. doi:10.1016/0378-1119(95)00571-4. PMID 8543184.

[entrez-7] "Entrez Gene: RNPS1 RNA binding protein S1, serine-rich domain".

[pmid11477570-8] Harada K, Yamada A, Yang D, Itoh K, Shichijo S (Sep 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570. S2CID 24724555.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid14517304-10] Li C, Lin RI, Lai MC, Ouyang P, Tarn WY (Oct 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Molecular and Cellular Biology. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. PMC 230327. PMID 14517304.

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RNPS1

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목차

기능.

상호 작용

레퍼런스

추가 정보

외부 링크