RAD51L3

RAD51D
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	2KZ3
식별자
별칭	RAD51D, BroVCA4, R51H3, RAD51L3, TRAD, RAD51 파라로그 D
외부 ID	OMIM: 602954 MGI: 1261809 HomoloGene: 2156 GeneCard: RAD51D
유전자 위치(인간)
쳇.	17번 염색체(인간)
끝	35,195,522 bp
유전자 위치(마우스)
쳇.	11번 염색체(쥐)
끝	82,781,192 bp
RNA 표현 패턴
	표현된 상단
	장기 체계; ; 모낭; ; 전두엽 피질; ; 뱃속; ; 고환;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	DNA 결합; 뉴클레오티드 결합; ATP 의존적 활동, DNA에 작용; DNA 가닥 교환 활동; 단일 가닥의 DNA 결합; GO:0001948 단백질 결합; 4방향 접합 DNA 결합; 감마관 결합; 이중 가닥의 DNA 결합; 엔도독시리보뉴클레아 활동; ATP 바인딩;
셀룰러 컴포넌트	세포질; 센트로놈의; 복제 포크; 염색체; 미세관 조직 센터; 염색체, 말단부; Rad51B-Rad51C-Rad51D-XRCC2 복합체; 시토스켈레톤; 핵의; 핵종의;
생물학적 과정	가닥의 침입; 전리방사선에 대한 반응; 뉴클레오티드-제분 보수; 상호 감수성 재조합; DNA 재조합; 교차 링크 수리; 염색체 조직; 세포 주기 조절; DNA 손상 자극에 대한 세포 반응; 체세포 재조합; 말단소립 정비; DNA 수리; 감수성 DNA 재조합; 균질 재조합을 통한 이중 패시브 브레이크 수리;
	출처:아미고 / 퀵고
직교체
	5892
	19364
	ENSG00000185379
	ENSMUSG00000018841
	O75771
	O55230
NM_001142571; NM_002878; NM_133627; NM_133628; NM_133629;
	NM_133630
	NM_001277938; NM_001277939; NM_001277941; NM_001277942; NM_011235
	NP_001136043; NP_002869; NP_598332
	NP_001264867; NP_001264868; NP_001264870; NP_001264871; NP_035365
	위키다타
인간 보기/편집	마우스 보기/편집

DNA 수리 단백질 RAD51 homolog 4는 인간에서 RAD51L3 유전자에 의해 암호화된 단백질이다.^[5]^[6]

함수

이 유전자에 의해 암호화된 단백질은 RAD51 단백질 계열의 일원이다.RAD51 가족 구성원은 DNA의 동질적 재조합과 수리에 관여하는 것으로 알려진 박테리아 레카, 사카로마이오스 세레비시아에 래드51과 매우 유사하다.이 단백질은 RAD51L1, RAD51L2, XRCC2 등 RAD51 계열의 다른 여러 구성원과 콤플렉스를 형성한다.이 단백질로 형성된 단백질 복합체는 단일 가닥 DNA와 이중 가닥 DNA의 호몰로커 페어링을 촉진하는 것으로 나타났으며, DNA 재조합 수리의 초기 단계에 역할을 하는 것으로 생각된다.이 유전자의 여러 가지 대안으로 분열된 대본 변형이 설명되었지만, 그들 중 일부의 생물학적 타당성은 결정되지 않았다.^[6]

상호작용

RAD51L3은 다음과 상호작용하는 것으로 나타났다.

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000185379 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000018841 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pittman DL, Weinberg LR, Schimenti JC (June 1998). "Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene". Genomics. 49 (1): 103–11. doi:10.1006/geno.1998.5226. PMID 9570954.
^ ^a ^b "Entrez Gene: RAD51L3 RAD51-like 3 (S. cerevisiae)".
^ ^a ^b Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID (November 2003). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". J. Biol. Chem. 278 (48): 48357–66. doi:10.1074/jbc.M308838200. hdl:10026.1/10297. PMID 12975363.
^ ^a ^b Liu N, Schild D, Thelen MP, Thompson LH (February 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113.
^ Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
^ Schild D, Lio YC, Collins DW, Tsomondo T, Chen DJ (June 2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". J. Biol. Chem. 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.
^ Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.

추가 읽기

Cartwright R, Dunn AM, Simpson PJ, Tambini CE, Thacker J (1998). "Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family". Nucleic Acids Res. 26 (7): 1653–9. doi:10.1093/nar/26.7.1653. PMC 147465. PMID 9512535.
Kawabata M, Saeki K (1999). "Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the rec A/RAD51 gene family". Biochem. Biophys. Res. Commun. 257 (1): 156–62. doi:10.1006/bbrc.1999.0413. PMID 10092526.
Schild D, Lio YC, Collins DW, Tsomondo T, Chen DJ (2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". J. Biol. Chem. 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.
Braybrooke JP, Spink KG, Thacker J, Hickson ID (2000). "The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2". J. Biol. Chem. 275 (37): 29100–6. doi:10.1074/jbc.M002075200. PMID 10871607.
Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
Masson JY, Tarsounas MC, Stasiak AZ, Stasiak A, Shah R, McIlwraith MJ, Benson FE, West SC (2001). "Identification and purification of two distinct complexes containing the five RAD51 paralogs". Genes Dev. 15 (24): 3296–307. doi:10.1101/gad.947001. PMC 312846. PMID 11751635.
Sigurdsson S, Van Komen S, Bussen W, Schild D, Albala JS, Sung P (2001). "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange". Genes Dev. 15 (24): 3308–18. doi:10.1101/gad.935501. PMC 312844. PMID 11751636.
Kurumizaka H, Ikawa S, Nakada M, Enomoto R, Kagawa W, Kinebuchi T, Yamazoe M, Yokoyama S, Shibata T (2002). "Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex". J. Biol. Chem. 277 (16): 14315–20. doi:10.1074/jbc.M105719200. PMID 11834724.
Wiese C, Collins DW, Albala JS, Thompson LH, Kronenberg A, Schild D (2002). "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells". Nucleic Acids Res. 30 (4): 1001–8. doi:10.1093/nar/30.4.1001. PMC 100332. PMID 11842112.
Liu N, Schild D, Thelen MP, Thompson LH (2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113.
Godthelp BC, Artwert F, Joenje H, Zdzienicka MZ (2002). "Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1". Oncogene. 21 (32): 5002–5. doi:10.1038/sj.onc.1205656. PMID 12118380.
Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID (2003). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". J. Biol. Chem. 278 (48): 48357–66. doi:10.1074/jbc.M308838200. hdl:10026.1/10297. PMID 12975363.
Hillman RT, Green RE, Brenner SE (2004). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Tarsounas M, Davies AA, West SC (2004). "RAD51 localization and activation following DNA damage". Philos. Trans. R. Soc. Lond. B Biol. Sci. 359 (1441): 87–93. doi:10.1098/rstb.2003.1368. PMC 1693300. PMID 15065660.
Tarsounas M, Muñoz P, Claas A, Smiraldo PG, Pittman DL, Blasco MA, West SC (2004). "Telomere maintenance requires the RAD51D recombination/repair protein". Cell. 117 (3): 337–47. doi:10.1016/S0092-8674(04)00337-X. PMID 15109494. S2CID 16478454.
Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.
Rodríguez-López R, Osorio A, Ribas G, Pollán M, Sánchez-Pulido L, de la Hoya M, Ruibal A, Zamora P, Arias JI, Salazar R, Vega A, Martínez JI, Esteban-Cardeñosa E, Alonso C, Letón R, Urioste Azcorra M, Miner C, Armengod ME, Carracedo A, González-Sarmiento R, Caldés T, Díez O, Benítez J (2004). "The variant E233G of the RAD51D gene could be a low-penetrance allele in high-risk breast cancer families without BRCA1/2 mutations". Int. J. Cancer. 110 (6): 845–9. doi:10.1002/ijc.20169. PMID 15170666. S2CID 6309119.
Loveday C, Turnbull C, Ramsay E, Hughes D, Ruark E, Frankum JR, Bowden G, Kalmyrzaev B, Warren-Perry M, Snape K, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Eccles D, Evans DG, Renwick A, Seal S, Lord CJ, Ashworth A, Reis-Filho JS, Antoniou AC, Rahman N (2011-08-07). "Germline mutations in RAD51D confer susceptibility to ovarian cancer". Nat. Genet. 43 (9): 879–82. doi:10.1038/ng.893. PMC 4845885. PMID 21822267.

17번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000185379 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000018841 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9570954-5] Pittman DL, Weinberg LR, Schimenti JC (June 1998). "Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene". Genomics. 49 (1): 103–11. doi:10.1006/geno.1998.5226. PMID 9570954.

[entrez-6] "Entrez Gene: RAD51L3 RAD51-like 3 (S. cerevisiae)".

[pmid12975363-7] Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID (November 2003). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". J. Biol. Chem. 278 (48): 48357–66. doi:10.1074/jbc.M308838200. hdl:10026.1/10297. PMID 12975363.

[pmid11842113-8] Liu N, Schild D, Thelen MP, Thompson LH (February 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113.

[pmid11744692-9] Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.

[pmid10749867-10] Schild D, Lio YC, Collins DW, Tsomondo T, Chen DJ (June 2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". J. Biol. Chem. 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.

[pmid15115758-11] Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.

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RAD51L3

네임스페이스

더

목차

함수

상호작용

참조

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